Susan Lindquist

Whitehead Institute for Biomedical Research, MIT - Massachusetts Institute of Technology

Affiliated withMIT - Massachusetts Institute of Technology Whitehead Institute for Biomedical Research Howard Hughes Medical Institute

Research Area

Biology

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 2	2008
Publication title Cited by 187	2008

Other Publications

Article	Year
Cooperative kinetics of both Hsp104 ATPase domains and interdomain communication revealed by AAA sensor-1 mutants. The EMBO journal\| PubMed ID: 11782421	2002
Susan L. Lindquist. Trends in cell biology\| PubMed ID: 11859028	2002
Analysis of the AAA sensor-2 motif in the C-terminal ATPase domain of Hsp104 with a site-specific fluorescent probe of nucleotide binding. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11867765	2002
Defining a pathway of communication from the C-terminal peptide binding domain to the N-terminal ATPase domain in a AAA protein. Molecular cell\| PubMed ID: 11983167	2002
Hsp90 as a capacitor of phenotypic variation. Nature\| PubMed ID: 12050657	2002
Analysis of prion factors in yeast. Methods in enzymology\| PubMed ID: 12073366	2002
Prions as protein-based genetic elements. Annual review of microbiology\| PubMed ID: 12142498	2002
Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol. Science (New York, N.Y.)\| PubMed ID: 12386336	2002
Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol. Science (New York, N.Y.)\| PubMed ID: 12386337	2002
Changes in the middle region of Sup35 profoundly alter the nature of epigenetic inheritance for the yeast prion [PSI+]. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12461168	2002
Self-perpetuating structural states in biology, disease, and genetics. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12475994	2002
Conducting nanowires built by controlled self-assembly of amyloid fibers and selective metal deposition. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12672964	2003
Hsp90 and chromatin: where is the link? Cell cycle (Georgetown, Tex.)\| PubMed ID: 12734413	2003
Prion protein gene polymorphisms in Saccharomyces cerevisiae. Molecular microbiology\| PubMed ID: 12890024	2003
Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. Science (New York, N.Y.)\| PubMed ID: 14657499	2003
Yeast cells provide insight into alpha-synuclein biology and pathobiology. Science (New York, N.Y.)\| PubMed ID: 14657500	2003
A neuronal isoform of the aplysia CPEB has prion-like properties. Cell\| PubMed ID: 14697205	2003
Dominant gain-of-function mutations in Hsp104p reveal crucial roles for the middle region. Molecular biology of the cell\| PubMed ID: 14978213	2004
The elongation of yeast prion fibers involves separable steps of association and conversion. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14983002	2004
Under cover: causes, effects and implications of Hsp90-mediated genetic capacitance. BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 15057933	2004
Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease. Journal of molecular neuroscience : MN\| PubMed ID: 15126689	2004
Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers. Science (New York, N.Y.)\| PubMed ID: 15155912	2004
Epigenetic regulation of translation reveals hidden genetic variation to produce complex traits. Nature\| PubMed ID: 15311209	2004
Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [PSI+] prion in yeast and aggregation of Sup35 in vitro. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15326312	2004
Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15598740	2004
Navigating the ClpB channel to solution. Nature structural & molecular biology\| PubMed ID: 15689967	2005
A chaperone pathway in protein disaggregation. Hsp26 alters the nature of protein aggregates to facilitate reactivation by Hsp104. The Journal of biological chemistry\| PubMed ID: 15845535	2005
Prions as adaptive conduits of memory and inheritance. Nature reviews. Genetics\| PubMed ID: 15931169	2005
Structural insights into a yeast prion illuminate nucleation and strain diversity. Nature\| PubMed ID: 15944694	2005
Prion proteins: one surprise after another. Harvey lectures\| PubMed ID: 16033161	2002
HSP90 and the chaperoning of cancer. Nature reviews. Cancer\| PubMed ID: 16175177	2005
Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi. Science (New York, N.Y.)\| PubMed ID: 16195452	2005
Increase in activity during calorie restriction requires Sirt1. Science (New York, N.Y.)\| PubMed ID: 16339438	2005
Harnessing natural diversity to probe metabolic pathways. PLoS genetics\| PubMed ID: 16429164	2005
Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16467153	2006
Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16492732	2006
Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science (New York, N.Y.)\| PubMed ID: 16794039	2006
A network of protein interactions determines polyglutamine toxicity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16832049	2006
Flanking sequences profoundly alter polyglutamine toxicity in yeast. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16832050	2006
Destruction or potentiation of different prions catalyzed by similar Hsp104 remodeling activities. Molecular cell\| PubMed ID: 16885031	2006
Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models. Human molecular genetics\| PubMed ID: 16893904	2006
Genetic architecture of Hsp90-dependent drug resistance. Eukaryotic cell\| PubMed ID: 17056742	2006
Asymmetric deceleration of ClpB or Hsp104 ATPase activity unleashes protein-remodeling activity. Nature structural & molecular biology\| PubMed ID: 17259993	2007
The power of automated high-resolution behavior analysis revealed by its application to mouse models of Huntington's and prion diseases. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17261803	2007
A natively unfolded yeast prion monomer adopts an ensemble of collapsed and rapidly fluctuating structures. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17299036	2007
Prion recognition elements govern nucleation, strain specificity and species barriers. Nature\| PubMed ID: 17495929	2007
A suite of Gateway cloning vectors for high-throughput genetic analysis in Saccharomyces cerevisiae. Yeast (Chichester, England)\| PubMed ID: 17583893	2007
Phenotypic diversity and altered environmental plasticity in Arabidopsis thaliana with reduced Hsp90 levels. PloS one\| PubMed ID: 17653275	2007
Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell\| PubMed ID: 17889646	2007
Probing the role of PrP repeats in conformational conversion and amyloid assembly of chimeric yeast prions. The Journal of biological chemistry\| PubMed ID: 17893150	2007
Alternative assembly pathways of the amyloidogenic yeast prion determinant Sup35-NM. EMBO reports\| PubMed ID: 17975557	2007
Diminishing apoptosis by deletion of Bax or overexpression of Bcl-2 does not protect against infectious prion toxicity in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18032675	2007
Illuminating aggregate heterogeneity in neurodegenerative disease. Nature methods\| PubMed ID: 18049468	2007
Atypical AAA+ subunit packing creates an expanded cavity for disaggregation by the protein-remodeling factor Hsp104. Cell\| PubMed ID: 18160044	2007
The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18162536	2008
HSP90-buffered genetic variation is common in Arabidopsis thaliana. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18287064	2008
HSP90 affects the expression of genetic variation and developmental stability in quantitative traits. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18287065	2008
Hsp110 chaperones regulate prion formation and propagation in S. cerevisiae by two discrete activities. PloS one\| PubMed ID: 18335038	2008
Detection of compounds that rescue Rab1-synuclein toxicity. Methods in enzymology\| PubMed ID: 18374176	2008
A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18434538	2008
Chaperone-dependent amyloid assembly protects cells from prion toxicity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18480252	2008
Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18480256	2008
Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease. The Journal of clinical investigation\| PubMed ID: 18704197	2008
Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18757733	2008
The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration. Experimental gerontology\| PubMed ID: 18799131	2008
Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions. The EMBO journal\| PubMed ID: 18833196	2008
Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity. Genes & development\| PubMed ID: 19015277	2008
Using yeast to understand protein folding diseases: an interview with Susan Lindquist by Kristin Kain. Disease models & mechanisms\| PubMed ID: 19048046	2008
Prion switching in response to environmental stress. PLoS biology\| PubMed ID: 19067491	2008
Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas. Immunity\| PubMed ID: 19100703	2008
Evidence that alpha-synuclein does not inhibit phospholipase D. Biochemistry\| PubMed ID: 19146388	2009
The prion protein knockout mouse: a phenotype under challenge. Prion\| PubMed ID: 19164918	2007
Prion pathogenesis is independent of caspase-12. Prion\| PubMed ID: 19164919	2007
Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity. Nature genetics\| PubMed ID: 19182805	2009
Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19196973	2009
Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. Nature genetics\| PubMed ID: 19234470	2009
BETASCAN: probable beta-amyloids identified by pairwise probabilistic analysis. PLoS computational biology\| PubMed ID: 19325876	2009
Inhibiting the transcription factor HSF1 as an anticancer strategy. Expert opinion on therapeutic targets\| PubMed ID: 19335068	2009
A systematic survey identifies prions and illuminates sequence features of prionogenic proteins. Cell\| PubMed ID: 19345193	2009
A nucleolar protein allows viability in the absence of the essential ER-residing molecular chaperone calnexin. Journal of cell science\| PubMed ID: 19351719	2009
Motor mechanism for protein threading through Hsp104. Molecular cell\| PubMed ID: 19362537	2009
Amyloid deposits: protection against toxic protein species? Cell cycle (Georgetown, Tex.)\| PubMed ID: 19411847	2009
Unraveling infectious structures, strain variants and species barriers for the yeast prion [PSI+]. Nature structural & molecular biology\| PubMed ID: 19491937	2009
Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models. Nature chemical biology\| PubMed ID: 19597508	2009
Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19605647	2009
Spontaneous generation of prion infectivity in fatal familial insomnia knockin mice. Neuron\| PubMed ID: 19709627	2009
The Schizosaccharomyces pombe Hsp104 disaggregase is unable to propagate the [PSI] prion. PloS one\| PubMed ID: 19759825	2009
A heritable switch in carbon source utilization driven by an unusual yeast prion. Genes & development\| PubMed ID: 19797769	2009
Context-dependent perturbation of neural systems in transgenic mice expressing a cytosolic prion protein. NeuroImage\| PubMed ID: 19835963	2010
Context dependent neuroprotective properties of prion protein (PrP). Prion\| PubMed ID: 19901559	2009
Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models. Disease models & mechanisms\| PubMed ID: 20038714	2010
Prions, protein homeostasis, and phenotypic diversity. Trends in cell biology\| PubMed ID: 20071174	2010
Prion induction involves an ancient system for the sequestration of aggregated proteins and heritable changes in prion fragmentation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20421488	2010
Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast? Nature reviews. Neuroscience\| PubMed ID: 20424620	2010
Conversion of a yeast prion protein to an infectious form in bacteria. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20484678	2010
Î±-Synuclein: membrane interactions and toxicity in Parkinson's disease. Annual review of cell and developmental biology\| PubMed ID: 20500090	2010
HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nature reviews. Molecular cell biology\| PubMed ID: 20531426	2010
Polyamine pathway contributes to the pathogenesis of Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20837543	2010
Biochemical, cell biological, and genetic assays to analyze amyloid and prion aggregation in yeast. Methods in enzymology\| PubMed ID: 20946833	2010
Epigenetics in the extreme: prions and the inheritance of environmentally acquired traits. Science (New York, N.Y.)\| PubMed ID: 21030648	2010
Protein homeostasis and the phenotypic manifestation of genetic diversity: principles and mechanisms. Annual review of genetics\| PubMed ID: 21047258	2010
Three quite different things that matter to me. Molecular biology of the cell\| PubMed ID: 21079020	2010
Optical trapping with high forces reveals unexpected behaviors of prion fibrils. Nature structural & molecular biology\| PubMed ID: 21113168	2010
Hsp90 and environmental stress transform the adaptive value of natural genetic variation. Science (New York, N.Y.)\| PubMed ID: 21205668	2010
Cyclin-G-associated kinase modifies Î±-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study. Human molecular genetics\| PubMed ID: 21258085	2011
Protein-only mechanism induces self-perpetuating changes in the activity of neuronal Aplysia cytoplasmic polyadenylation element binding protein (CPEB). Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21270333	2011
The cellular prion protein mediates neurotoxic signalling of Î²-sheet-rich conformers independent of prion replication. The EMBO journal\| PubMed ID: 21441896	2011
A yeast model of FUS/TLS-dependent cytotoxicity. PLoS biology\| PubMed ID: 21541368	2011
ResponseNet: revealing signaling and regulatory networks linking genetic and transcriptomic screening data. Nucleic acids research\| PubMed ID: 21576238	2011
A flurry of folding problems: an interview with Susan Lindquist by Jane Gitschier. PLoS genetics\| PubMed ID: 21589898	2011
Prion formation and polyglutamine aggregation are controlled by two classes of genes. PLoS genetics\| PubMed ID: 21625618	2011
A method for probing the mutational landscape of amyloid structure. Bioinformatics (Oxford, England)\| PubMed ID: 21685090	2011
Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins. Molecular cell\| PubMed ID: 21726811	2011
Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell\| PubMed ID: 21757228	2011
Physical properties of polymorphic yeast prion amyloid fibers. Biophysical journal\| PubMed ID: 21767497	2011
Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates. Bioorganic & medicinal chemistry letters\| PubMed ID: 21802942	2011
TorsinA and the torsinA-interacting protein printor have no impact on endoplasmic reticulum stress or protein trafficking in yeast. PloS one\| PubMed ID: 21818381	2011
Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosis. Cold Spring Harbor perspectives in biology\| PubMed ID: 21900404	2011
Functional links between AÎ² toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast. Science (New York, N.Y.)\| PubMed ID: 22033521	2011
High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22042860	2011
Using the Heat-Shock Response To Discover Anticancer Compounds that Target Protein Homeostasis. ACS chemical biology\| PubMed ID: 22050377	2011
STITCHER: Dynamic assembly of likely amyloid and prion Î²-structures from secondary structure predictions. Proteins\| PubMed ID: 22095906	2011
QnAs with Susan L. Lindquist. Interviewed by Prashant Nair. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22123945	2011
Different 8-Hydroxyquinolines Protect Models of TDP-43 Protein, Î±-Synuclein, and Polyglutamine Proteotoxicity through Distinct Mechanisms. The Journal of biological chemistry\| PubMed ID: 22147697	2012
SIRT1 protects against Î±-synuclein aggregation by activating molecular chaperones. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22219275	2012
Prions are a common mechanism for phenotypic inheritance in wild yeasts. Nature\| PubMed ID: 22337056	2012