screening-axonal-degeneration-carpal-tunnel-syndrome-using

Screening of Axonal Degeneration in Carpal Tunnel Syndrome Using Ultrasonography and Nerve Conduction Studies

Axonal degeneration, indicative of surgical decompression, may coexist in carpal tunnel syndrome (CTS) as the disease progresses. However, the current ...

The University of Hong Kong

Ultrashort time-to-echo (UTE) MRI scanning has been applied to observe the cartilaginous endplate (CEP) in intervertebral disc. CEP plays a critical role in IVD health and disease. Nevertheless, current measurements of CEP based on UTE MRI technique are still by manual segmentation, and observation of signal abnormality was usually time-consuming and often disturbed by subjective bias. This study hence proposed an efficient way to harvest the global parameters of CEP after UTE MRI scanning.

A computational measurement of cartilaginous endplate structure using ultrashort time-to-echo MRI scanning.

This study aims to determine whether the time-frequency components (TFCs) of somatosensory evoked potentials (SEPs) can be used to identify the specific location of a compressive spinal cord injury using a classification technique. Waveforms of SEPs after compressive injuries at various locations (C4, C5 and C6) in rat spinal cords were decomposed into a series of TFCs using a high-resolution time-frequency analysis method. A classification method based on support vector machine (SVM) was applied to the distributions of these TFCs among different pathological locations. The difference among injury locations manifests itself in different categories of SEP TFCs. High-energy TFCs of normal-state SEPs have significantly higher power and frequency than those of injury-state SEPs. The location of C5 is characterized by a unique distribution pattern of middle-energy TFCs. The difference between C4 and C6 is evidenced by the distribution pattern of low-energy TFCs. The proposed classification method based on SEP TFCs offers a discrimination accuracy of 80.2%. In this study, meaningful information contained in various SEP components was investigated and used to propose a new application of SEPs for identification of the location of pathological changes in the cervical spinal cord.

Component analysis of somatosensory evoked potentials for identifying spinal cord injury location.

This study aimed to examine alterations in electroencephalography (EEG) phase synchronization in working memory processing in depressed patients. Sixty-four-channel EEG signals were recorded from 33 depressed patients and 32 healthy controls during a visual n-back task. Alterations in functional connections in the patients were investigated using event-related phase coherence in terms of the phase synchronization index (PSI). Compared with the control subjects, the depressed patients showed a lower task-dependent increase in the PSI of delta, theta, and alpha oscillations in a frontoparietal network, but a higher task-dependent increase in the PSI of beta oscillations in the frontoparietal network. Additionally, depressed patients showed a lower task-dependent decrease in the PSI of delta, theta, alpha, and beta oscillations in centro-parieto-occipital sites. Insufficient phase synchronization and desynchronization during working memory processing reflects impairments in cortical inhibition, memory, and attention efficiency in major depression, while the abnormal increase in phase synchronization in beta oscillations in the frontoparietal network may indicate a new cortical circuit concerned with the repair of impaired ability in attention, memory retention, and working memory central executive processing. These findings present a compensatory mechanism for impaired cognitive function in major depression, and advance our understanding of functional aspect of beta oscillations.

Article	Year
A computational measurement of cartilaginous endplate structure using ultrashort time-to-echo MRI scanning. Computer methods and programs in biomedicine\| PubMed ID: 28391818	2017
Component analysis of somatosensory evoked potentials for identifying spinal cord injury location. Scientific reports\| PubMed ID: 28539587	2017
Beta oscillations in major depression - signalling a new cortical circuit for central executive function. Scientific reports\| PubMed ID: 29269891	2017

Yong Hu

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