Frederick A. Villamena

The Davis Heart and Lung Research Institute, The Ohio State University

Affiliated withThe Ohio State University College of Medicine, The Ohio State University

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 40	2012

Other Publications

Article	Year
Theoretical study of the spin trapping of hydroxyl radical by cyclic nitrones: a density functional theory approach. Journal of the American Chemical Society\| PubMed ID: 14871114	2004
Detection of reactive oxygen and nitrogen species by EPR spin trapping. Antioxidants & redox signaling\| PubMed ID: 15130289	2004
Spin trapping by 5-carbamoyl-5-methyl-1-pyrroline N-oxide (AMPO): theoretical and experimental studies. The Journal of organic chemistry\| PubMed ID: 15527282	2004
Cancer chemopreventive oltipraz generates superoxide anion radical. Archives of biochemistry and biophysics\| PubMed ID: 15680910	2005
Glutathione-mediated formation of oxygen free radicals by the major metabolite of oltipraz. Chemical research in toxicology\| PubMed ID: 15962931	2005
Nitric oxide release from the unimolecular decomposition of the superoxide radical anion adduct of cyclic nitrones in aqueous medium. Organic & biomolecular chemistry\| PubMed ID: 16106305	2005
Comparative DFT study of the spin trapping of methyl, mercapto, hydroperoxy, superoxide, and nitric oxide radicals by various substituted cyclic nitrones. The journal of physical chemistry. A\| PubMed ID: 16833491	2005
Superoxide radical anion adduct of 5,5-dimethyl-1-pyrroline n-oxide (DMPO). 1. The thermodynamics of formation and its acidity. The journal of physical chemistry. A\| PubMed ID: 16833945	2005
Superoxide radical anion adduct of 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 2. The thermodynamics of decay and EPR spectral properties. The journal of physical chemistry. A\| PubMed ID: 16833946	2005
Evidence for increased exchange interactions with 5d compared to 4d metal ions. Experimental and theoretical insights into the ferromagnetic interactions of a series of trinuclear [{M(CN)8}3... Journal of the American Chemical Society\| PubMed ID: 16881650	2006
Reactivity of molecular oxygen with ethoxycarbonyl derivatives of tetrathiatriarylmethyl radicals. The Journal of organic chemistry\| PubMed ID: 16958520	2006
Theoretical and experimental studies of the spin trapping of inorganic radicals by 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 1. Carbon dioxide radical anion. The journal of physical chemistry. A\| PubMed ID: 17149843	2006
Theoretical and experimental studies of the spin trapping of inorganic radicals by 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 2. Carbonate radical anion. The journal of physical chemistry. A\| PubMed ID: 17214476	2007
4-Aryl-1,3,2-oxathiazolylium-5-olates as pH-controlled NO-donors: the next generation of S-nitrosothiols. Journal of the American Chemical Society\| PubMed ID: 17419627	2007
Synthesis and characterization of a perchlorotriphenylmethyl (trityl) triester radical: a potential sensor for superoxide and oxygen in biological systems. Bioorganic & medicinal chemistry letters\| PubMed ID: 17499990	2007
Reactivity of superoxide radical anion with cyclic nitrones: role of intramolecular H-bond and electrostatic effects. Journal of the American Chemical Society\| PubMed ID: 17564447	2007
Rate constants of hydroperoxyl radical addition to cyclic nitrones: a DFT study. The journal of physical chemistry. A\| PubMed ID: 17845014	2007
Large-scale synthesis of a persistent trityl radical for use in biomedical EPR applications and imaging. Bioorganic & medicinal chemistry letters\| PubMed ID: 17964156	2007
Reactivity of superoxide anion radical with a perchlorotriphenylmethyl (trityl) radical. The journal of physical chemistry. B\| PubMed ID: 18081340	2008
Inactivation of mitochondrial respiratory chain complex I leads mitochondrial nitric oxide synthase to become pro-oxidative. Biochemical and biophysical research communications\| PubMed ID: 18191636	2008
Synthesis and characterization of ester-derivatized tetrathiatriarylmethyl radicals as intracellular oxygen probes. The Journal of organic chemistry\| PubMed ID: 18201099	2008
Superoxide radical anion adduct of 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 3. Effect of mildly acidic pH on the thermodynamics and kinetics of adduct formation. The journal of physical chemistry. A\| PubMed ID: 18303874	2008
Synthesis and spin-trapping properties of a new spirolactonyl nitrone. The Journal of organic chemistry\| PubMed ID: 18331054	2008
Improved spin trapping properties by beta-cyclodextrin-cyclic nitrone conjugate. The Journal of organic chemistry\| PubMed ID: 18707169	2008
Highly stable dendritic trityl radicals as oxygen and pH probe. Chemical communications (Cambridge, England)\| PubMed ID: 18802562	2008
Theoretical and experimental studies of tyrosyl hydroperoxide formation in the presence of H-bond donors. Chemical research in toxicology\| PubMed ID: 18816073	2008
Reactivity of superoxide radical anion and hydroperoxyl radical with alpha-phenyl-N-tert-butylnitrone (PBN) derivatives. The journal of physical chemistry. A\| PubMed ID: 18998656	2008
Superoxide radical anion adduct of 5,5-dimethyl-1-pyrroline N-oxide. 4. Conformational effects on the EPR hyperfine splitting constants. The journal of physical chemistry. A\| PubMed ID: 19012384	2008
Esterified trityl radicals as intracellular oxygen probes. Free radical biology & medicine\| PubMed ID: 19135524	2009
The radical trap 5,5-dimethyl-1-pyrroline N-oxide exerts dose-dependent protection against myocardial ischemia-reperfusion injury through preservation of mitochondrial electron transport. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 19201989	2009
Superoxide radical anion adduct of 5,5-dimethyl-1-pyrroline N-oxide. 5. Thermodynamics and kinetics of unimolecular decomposition. The journal of physical chemistry. A\| PubMed ID: 19425559	2009
Lipophilic beta-cyclodextrin cyclic-nitrone conjugate: synthesis and spin trapping studies. The Journal of organic chemistry\| PubMed ID: 19530689	2009
Spin trapping and cytoprotective properties of fluorinated amphiphilic carrier conjugates of cyclic versus linear nitrones. Chemical research in toxicology\| PubMed ID: 19678661	2009
Perchlorotrityl radical-fluorophore conjugates as dual fluorescence and EPR probes for superoxide radical anion. Bioorganic & medicinal chemistry\| PubMed ID: 19963389	2010
Superoxide radical anion adduct of 5,5-dimethyl-1-pyrroline N-oxide. 6. Redox properties. The journal of physical chemistry. A\| PubMed ID: 19968309	2010
Trityl-nitroxide biradicals as unique molecular probes for the simultaneous measurement of redox status and oxygenation. Chemical communications (Cambridge, England)\| PubMed ID: 20062884	2010
Amphiphilic amide nitrones: a new class of protective agents acting as modifiers of mitochondrial metabolism. Journal of medicinal chemistry\| PubMed ID: 20527971	2010
Synthesis of (14)N- and (15)N-labeled Trityl-nitroxide Biradicals with Strong Spin-Spin Interaction and Improved Sensitivity to Redox Status and Oxygen. The Journal of organic chemistry\| PubMed ID: 21028905	2010
Fast Reactivity of a Cyclic Nitrone-Calix[4]pyrrole Conjugate with Superoxide Radical Anion: Theoretical and Experimental Studies (â€ ). Journal of the American Chemical Society\| PubMed ID: 21070040	2010
Synthesis of trityl radical-conjugated disulfide biradicals for measurement of thiol concentration. The Journal of organic chemistry\| PubMed ID: 21488696	2011
Physicochemical and toxicological properties of commercial carbon blacks modified by reaction with ozone. Environmental science & technology\| PubMed ID: 22054302	2011
Reactivities of superoxide and hydroperoxyl radicals with disubstituted cyclic nitrones: a DFT study. The journal of physical chemistry. A\| PubMed ID: 22085265	2012
Synthesis of tris-hydroxymethyl-based nitrone derivatives with highly reactive nitronyl carbon. The Journal of organic chemistry\| PubMed ID: 22188016	2012
Inhibition of ROS-induced apoptosis in endothelial cells by nitrone spin traps via induction of phase II enzymes and suppression of mitochondria-dependent pro-apoptotic signaling. Biochemical pharmacology\| PubMed ID: 22580046	2012
Theoretical and Experimental Studies of the Spin Trapping of Inorganic Radicals by 5,5-Dimethyl-1-pyrroline N-Oxide (DMPO). 3. Sulfur Dioxide, Sulfite, and Sulfate Radical Anions. The journal of physical chemistry. A\| PubMed ID: 22668066	2012
Potential implication of the chemical properties and bioactivity of nitrone spin traps for therapeutics. Future medicinal chemistry\| PubMed ID: 22709256	2012
Reactive Nitrogen Species Reactivities with Nitrones: Theoretical and Experimental Studies. Chemical research in toxicology\| PubMed ID: 22775566	2012
Guest Inclusion in Cucurbiturils Studied by ESR and DFT: The Case of Nitroxide Radicals and Spin Adducts of DMPO and MNP. The journal of physical chemistry. A\| PubMed ID: 22830598	2012