observational-study-protocol-for-repeated-clinical-examination

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Longitudinal evaluations of critically ill patients by combinations of clinical examination, biochemical analysis and critical care ultrasonography (CCUS) ...

University Medical Center Groningen

Today's clinical research faces challenges such as a lack of clinical equipoise between treatment arms, reluctance in randomizing for multiple treatments simultaneously, inability to address interactions and increasingly restricted resources. Furthermore, many trials are biased by extensive exclusion criteria, relatively small sample size and less appropriate outcome measures.

More ethical and more efficient clinical research: multiplex trial design.

Prophylaxis for gastrointestinal stress ulceration is frequently given to patients in the intensive care unit (ICU), but its risks and benefits are unclear.

Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU.

Dopamine has been used in patients with cardiac dysfunction for more than five decades. Yet, no systematic review has assessed the effects of dopamine in critically ill patients with cardiac dysfunction.

Article	Year
More ethical and more efficient clinical research: multiplex trial design. BMC research notes\| PubMed ID: 25125365	2014
Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU. The New England journal of medicine\| PubMed ID: 30354950	2018
Dopamine in critically ill patients with cardiac dysfunction: A systematic review with meta-analysis and trial sequential analysis. Acta anaesthesiologica Scandinavica\| PubMed ID: 30515766	2018

Frederik Keus

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