isolation-characterization-human-umbilical-cord-derived-mesenchymal

Isolation and Characterization of Human Umbilical Cord-derived Mesenchymal Stem Cells from Preterm and Term Infants

Mesenchymal stem cells (MSCs) have considerable therapeutic potential and attract increasing interest in the biomedical field. MSCs are originally ...

Kobe University Graduate School of Medicine

The purpose of this study is to evaluate the cost-effectiveness of oseltamivir for influenza in Japan considering the complications and the emergence of oseltamivir-resistant virus.

Cost-effectiveness analysis of oseltamivir for influenza treatment considering the virus emerging resistant to the drug in Japan.

Recently, comprehensive genetic approaches for steroid-resistant nephrotic syndrome (SRNS) using next-generation sequencing (NGS) have been established, but causative gene mutations could not be detected in almost 70% of SRNS patients. Main reason for the low variant detection rate is that most of them are SRNS caused not by genetic but by immunological factors. But some of them are probably because of the difficulty of detecting copy number variations (CNVs) in causative genes by NGS.

Pair analysis and custom array CGH can detect a small copy number variation in COQ6 gene.

Gitelman syndrome (GS) is a tubulopathy exhibited by salt loss. GS cases are most often diagnosed by chance blood test. Aside from that, some cases are also diagnosed from tetanic symptoms associated with hypokalemia and/or hypomagnesemia or short stature. As for complications, thyroid dysfunction and short stature are known, but the incidence rates for these complications have not yet been elucidated. In addition, no genotype-phenotype correlation has been identified in GS.

Article	Year
Cost-effectiveness analysis of oseltamivir for influenza treatment considering the virus emerging resistant to the drug in Japan. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research\| PubMed ID: 20586984	2009
Pair analysis and custom array CGH can detect a small copy number variation in COQ6 gene. Clinical and experimental nephrology\| PubMed ID: 30584653	2018
Clinical and Genetic Characteristics in Patients With Gitelman Syndrome. Kidney international reports\| PubMed ID: 30596175	2019

Hiroaki Nagase

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