Dale W. Laird

Department of Anatomy and Cell Biology, University of Western Ontario

Affiliated withUniversity of Western Ontario

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 98	2011

Other Publications

Article	Year
Gap junctions assemble in the presence of cytoskeletal inhibitors, but enhanced assembly requires microtubules. Experimental cell research\| PubMed ID: 11925106	2002
Multicolor and electron microscopic imaging of connexin trafficking. Science (New York, N.Y.)\| PubMed ID: 11964472	2002
Retroviral delivery of connexin genes to human breast tumor cells inhibits in vivo tumor growth by a mechanism that is independent of significant gap junctional intercellular communication. The Journal of biological chemistry\| PubMed ID: 12042301	2002
Lysosomal and proteasomal degradation play distinct roles in the life cycle of Cx43 in gap junctional intercellular communication-deficient and -competent breast tumor cells. The Journal of biological chemistry\| PubMed ID: 12767974	2003
Transport and function of cx26 mutants involved in skin and deafness disorders. Cell communication & adhesion\| PubMed ID: 14681041	2003
Connexin26 regulates the expression of angiogenesis-related genes in human breast tumor cells by both GJIC-dependent and -independent mechanisms. Cell communication & adhesion\| PubMed ID: 14681046	2003
Functional domain mapping and selective trans-dominant effects exhibited by Cx26 disease-causing mutations. The Journal of biological chemistry\| PubMed ID: 14978038	2004
Selective assembly of connexin37 into heterocellular gap junctions at the oocyte/granulosa cell interface. Journal of cell science\| PubMed ID: 15138288	2004
Beta3 integrins facilitate matrix interactions during transendothelial migration of PC3 prostate tumor cells. The Prostate\| PubMed ID: 15468167	2005
Oculodentodigital dysplasia-causing connexin43 mutants are non-functional and exhibit dominant effects on wild-type connexin43. The Journal of biological chemistry\| PubMed ID: 15644317	2005
Down-regulation of Cx43 by retroviral delivery of small interfering RNA promotes an aggressive breast cancer cell phenotype. Cancer research\| PubMed ID: 15805269	2005
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation. Biochimica et biophysica acta\| PubMed ID: 15955302	2005
Connexin 43 mediated gap junctional communication enhances breast tumor cell diapedesis in culture. Breast cancer research : BCR\| PubMed ID: 15987459	2005
A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia. Development (Cambridge, England)\| PubMed ID: 16155213	2005
Mechanisms of Cx43 and Cx26 transport to the plasma membrane and gap junction regeneration. Journal of cell science\| PubMed ID: 16159960	2005
Life cycle of connexins in health and disease. The Biochemical journal\| PubMed ID: 16492141	2006
Rat epidermal keratinocytes as an organotypic model for examining the role of Cx43 and Cx26 in skin differentiation. Cell communication & adhesion\| PubMed ID: 16531317	2005
Functional characterization of oculodentodigital dysplasia-associated Cx43 mutants. Cell communication & adhesion\| PubMed ID: 16531323	2005
A histone deacetylation-dependent mechanism for transcriptional repression of the gap junction gene cx43 in prostate cancer cells. The Prostate\| PubMed ID: 16652385	2006
Cx26 inhibits breast MDA-MB-435 cell tumorigenic properties by a gap junctional intercellular communication-independent mechanism. Carcinogenesis\| PubMed ID: 16777986	2006
Functional characterization of a GJA1 frameshift mutation causing oculodentodigital dysplasia and palmoplantar keratoderma. The Journal of biological chemistry\| PubMed ID: 16891658	2006
Connexins act as tumor suppressors in three-dimensional mammary cell organoids by regulating differentiation and angiogenesis. Cancer research\| PubMed ID: 17047050	2006
Differential potency of dominant negative connexin43 mutants in oculodentodigital dysplasia. The Journal of biological chemistry\| PubMed ID: 17420259	2007
Differentiation of organotypic epidermis in the presence of skin disease-linked dominant-negative Cx26 mutants and knockdown Cx26. The Journal of membrane biology\| PubMed ID: 17638039	2007
Connexins and gap junctions in mammary gland development and breast cancer progression. The Journal of membrane biology\| PubMed ID: 17661126	2007
Connexin levels regulate keratinocyte differentiation in the epidermis. The Journal of biological chemistry\| PubMed ID: 17693411	2007
Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins. Journal of cell science\| PubMed ID: 17925379	2007
Closing the gap on autosomal dominant connexin-26 and connexin-43 mutants linked to human disease. The Journal of biological chemistry\| PubMed ID: 18089569	2008
Caveolin-1 and -2 interact with connexin43 and regulate gap junctional intercellular communication in keratinocytes. Molecular biology of the cell\| PubMed ID: 18162583	2008
The protective effect of functional connexin43 channels on a human epithelial cell line exposed to oxidative stress. Investigative ophthalmology & visual science\| PubMed ID: 18235030	2008
ODDD-linked Cx43 mutants reduce endogenous Cx43 expression and function in osteoblasts and inhibit late stage differentiation. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research\| PubMed ID: 18269311	2008
Zebrafish early cardiac connexin, Cx36.7/Ecx, regulates myofibril orientation and heart morphogenesis by establishing Nkx2.5 expression. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18337497	2008
Decreased levels of connexin43 result in impaired development of the mammary gland in a mouse model of oculodentodigital dysplasia. Developmental biology\| PubMed ID: 18455714	2008
Diverse subcellular distribution profiles of pannexin 1 and pannexin 3. Cell communication & adhesion\| PubMed ID: 18649185	2008
Fate of connexin43 in cardiac tissue harbouring a disease-linked connexin43 mutant. Cardiovascular research\| PubMed ID: 18678643	2008
Cx43 has distinct mobility within plasma-membrane domains, indicative of progressive formation of gap-junction plaques. Journal of cell science\| PubMed ID: 19174466	2009
A dominant loss-of-function GJA1 (Cx43) mutant impairs parturition in the mouse. Biology of reproduction\| PubMed ID: 19176884	2009
Oogenesis defects in a mutant mouse model of oculodentodigital dysplasia. Disease models & mechanisms\| PubMed ID: 19259389	2009
Glycosylation regulates pannexin intermixing and cellular localization. Molecular biology of the cell\| PubMed ID: 19692571	2009
光学和生化解剖的缝隙连接蛋白和疾病链接连接蛋白&#x7A8... Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19908013	2010
The gap junction proteome and its relationship to disease. Trends in cell biology\| PubMed ID: 19944606	2010
Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions. The Journal of biological chemistry\| PubMed ID: 20086016	2010
Milk secretion and ejection are impaired in the mammary gland of mice harboring a Cx43 mutant while expression and localization of tight and adherens junction proteins remain unchanged. Biology of reproduction\| PubMed ID: 20089884	2010
Implications of pannexin 1 and pannexin 3 for keratinocyte differentiation. Journal of cell science\| PubMed ID: 20332104	2010
The tumor-suppressive function of Connexin43 in keratinocytes is mediated in part via interaction with caveolin-1. Cancer research\| PubMed ID: 20406988	2010
Implications and challenges of connexin connections to cancer. Nature reviews. Cancer\| PubMed ID: 20495577	2010
The potency of the fs260 connexin43 mutant to impair keratinocyte differentiation is distinct from other disease-linked connexin43 mutants. The Biochemical journal\| PubMed ID: 20515445	2010
Hypoxia and reoxygenation-induced oxidant production increase in microvascular endothelial cells depends on connexin40. Free radical biology & medicine\| PubMed ID: 20541007	2010
Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. Nature\| PubMed ID: 20944749	2010
Ocular pathology relevant to glaucoma in a Gja1(Jrt/+) mouse model of human oculodentodigital dysplasia. Investigative ophthalmology & visual science\| PubMed ID: 21273537	2011
Human dermal fibroblasts derived from oculodentodigital dysplasia patients suggest that patients may have wound-healing defects. Human mutation\| PubMed ID: 21305658	2011
Characterization of pannexin1 and pannexin3 and their regulation by androgens in the male reproductive tract of the adult rat. Molecular reproduction and development\| PubMed ID: 21337450	2011
Pannexin channels are not gap junction hemichannels. Channels (Austin, Tex.)\| PubMed ID: 21532340	2011
Pannexin1 regulates Î±1-adrenergic receptor- mediated vasoconstriction. Circulation research\| PubMed ID: 21546608	2011
Rho signaling regulates pannexin 1-mediated ATP release from airway epithelia. The Journal of biological chemistry\| PubMed ID: 21606493	2011
Pathways regulating the trafficking and turnover of pannexin1 protein and the role of the C-terminal domain. The Journal of biological chemistry\| PubMed ID: 21659516	2011
The G60S connexin43 mutant regulates hair growth and hair fiber morphology in a mouse model of human oculodentodigital dysplasia. The Journal of investigative dermatology\| PubMed ID: 21716323	2011
Pannexin 3 is a novel target for Runx2, expressed by osteoblasts and mature growth plate chondrocytes. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research\| PubMed ID: 21915903	2011
The effect of connexin43 on the level of vascular endothelial growth factor in human retinal pigment epithelial cells. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie\| PubMed ID: 22138732	2011
The biochemistry and function of pannexin channels. Biochimica et biophysica acta\| PubMed ID: 22305965	2012