bio-energetics-investigation-candida-albicans-using-real-time

Bio-energetics Investigation of <em>Candida albicans</em> Using Real-time Extracellular Flux Analysis

Mitochondria are essential organelles for the cellular metabolism and survival. A variety of key events take place in mitochondria, such as cellular ...

The State University of New Jersey

Editorial overview: Molecular and genetic bases of disease.

In this issue of Cell Chemical Biology,Wiechmann et al. (2017) identify mitochondrial chaperonin HSP60 as a direct target of myrtucommulone (MC), a nonprenylated acylphloroglucinol that is well known for its apoptotic activity in cancer cells. The authors propose MC as a chemical probe to study HSP60 biology and a potential chemotherapeutic agent in treating cancer and other HSP60-associated diseases.

HSP60 Takes a Hit: Inhibition of Mitochondrial Protein Folding.

LonP1 is an essential mitochondrial protease, which is crucial for maintaining mitochondrial proteostasis and mitigating cell stress. However, the importance of LonP1 during cardiac stress is largely unknown.

Article	Year
Editorial overview: Molecular and genetic bases of disease. Current opinion in genetics & development\| PubMed ID: 27680305	2016
HSP60 Takes a Hit: Inhibition of Mitochondrial Protein Folding. Cell chemical biology\| PubMed ID: 28525768	2017
Mitochondrial LonP1 protects cardiomyocytes from ischemia/reperfusion injury in vivo. Journal of molecular and cellular cardiology\| PubMed ID: 30625302	2019

Carolyn Suzuki

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