development-implementation-multi-disciplinary-technology-enhanced

Development and Implementation of a Multi-Disciplinary Technology Enhanced Care Pathway for Youth and Adults with Concussion

The evidence-informed standardization of care along disease lines is recommended to improve outcomes and reduce healthcare costs. The aim of this project ...

Cleveland Clinic Foundation

To prospectively determine in patients with acute low back pain (LBP) or radiculopathy, the magnetic resonance (MR) imaging findings, prognostic role of these findings, and effect of diagnostic information on outcome.

Acute low back pain and radiculopathy: MR imaging findings and their prognostic role and effect on outcome.

Degenerative disc disease: genotyping, MR imaging and phenotyping.

The sequelae of disk degeneration are among the leading causes of functional incapacity in both sexes and are a common source of chronic disability in the working years. Disk degeneration involves structural disruption and cell-mediated changes in composition. Mechanical, traumatic, nutritional, and genetic factors all may play a role in the cascade of disk degeneration, albeit to variable degree in different individuals. The presence of degenerative change is by no means an indicator of symptoms, and there is a very high prevalence in asymptomatic individuals. The etiology of pain as the symptom of degenerative disease is complex and appears to be a combination of mechanical deformation and the presence of inflammatory mediators. The role of imaging is to provide accurate morphologic information and influence therapeutic decision making. A necessary component, which connects these two purposes, is accurate natural history data. Understanding the relationship of etiologic factors, the morphologic alterations, which can be characterized with imaging, and the mechanisms of pain production and their interactions in the production of symptoms will require more accurate and reproducible stratification of patient cohorts.

Article	Year
Acute low back pain and radiculopathy: MR imaging findings and their prognostic role and effect on outcome. Radiology\| PubMed ID: 16244269	2005
Degenerative disc disease: genotyping, MR imaging and phenotyping. Skeletal radiology\| PubMed ID: 16738912	2007
Lumbar degenerative disk disease. Radiology\| PubMed ID: 17885180	2007

Michael T. Modic

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