analyzing-oxygen-consumption-rate-primary-cultured-mouse-neonatal

Analyzing Oxygen Consumption Rate in Primary Cultured Mouse Neonatal Cardiomyocytes Using an Extracellular Flux Analyzer

Mitochondria and oxidative metabolism are critical for maintaining cardiac muscle function. Research has shown that mitochondrial dysfunction is an ...

University of California San Diego

The aim of this study was to investigate the resistance to blood flow in the ophthalmic artery of rabbits receiving topical treatment with timolol.

Resistance to blood flow in the rabbit ophthalmic artery after topical treatment with timolol.

The aim of this study was to investigate sympathetic influences on blood-flow velocity and resistance in the rabbit ophthalmic artery during the transition period from the light to the dark phase.

Sympathetic activities influence blood-flow velocity and resistance in the rabbit ophthalmic artery.

Cardiac fibrosis is one of the major components of the healing mechanism following any injury of the heart and as such may contribute to both systolic and diastolic dysfunction in a range of pathophysiologic conditions. Canonically, it can occur as part of the remodeling process that occurs following myocardial infarction or that follows as a response to pressure overload. Integrins are cell surface receptors which act in both cellular adhesion and signaling. Most importantly, in the context of the continuously contracting myocardium, they are recognized as mechanotransducers. They have been implicated in the development of fibrosis in several organs, including the heart. This review will focus on the involvement of integrins and integrin-related proteins, in cardiac fibrosis, outlining the roles of these proteins in the fibrotic responses in specific cardiac pathologies, discuss some of the common end effectors (angiotensin II, transforming growth factor beta 1 and mechanical stress) through which integrins function and finally discuss how manipulation of this set of proteins may lead to new treatments which could prove useful to alter the deleterious effects of cardiac fibrosis.

Article	Year
Resistance to blood flow in the rabbit ophthalmic artery after topical treatment with timolol. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics\| PubMed ID: 17444797	2007
Sympathetic activities influence blood-flow velocity and resistance in the rabbit ophthalmic artery. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics\| PubMed ID: 17444798	2007
Integrins and integrin-related proteins in cardiac fibrosis. Journal of molecular and cellular cardiology\| PubMed ID: 26562414	2016

Ruixia Li

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