John C. Bell

Center for Innovative Cancer Research, Ottawa Hospital Research Institute (OHRI)

Affiliated withOttawa Hospital Research Institute (OHRI)

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 22	2011

Other Publications

Article	Year
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Molecular cell\| PubMed ID: 12667446	2003
CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins. Biochemical and biophysical research communications\| PubMed ID: 12890497	2003
Getting oncolytic virus therapies off the ground. Cancer cell\| PubMed ID: 12892708	2003
VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents. Cancer cell\| PubMed ID: 14585354	2003
Vesicular stomatitis virus: re-inventing the bullet. Trends in molecular medicine\| PubMed ID: 15121047	2004
Activating transcription factor 4 is translationally regulated by hypoxic stress. Molecular and cellular biology\| PubMed ID: 15314157	2004
Vesicular stomatitis virus: a potential therapeutic virus for the treatment of hematologic malignancy. Human gene therapy\| PubMed ID: 15353037	2004
Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2alpha kinases PERK and PKR. Journal of virology\| PubMed ID: 15542627	2004
Internal translation initiation mediated by the angiogenic factor Tie2. The Journal of biological chemistry\| PubMed ID: 15802272	2005
Recent progress in the battle between oncolytic viruses and tumours. Nature reviews. Cancer\| PubMed ID: 16294217	2005
Internal ribosome entry site-mediated translation of Apaf-1, but not XIAP, is regulated during UV-induced cell death. The Journal of biological chemistry\| PubMed ID: 16595687	2006
A phase 1 clinical study of intravenous administration of PV701, an oncolytic virus, using two-step desensitization. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16638865	2006
Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress. Molecular and cellular biology\| PubMed ID: 17030613	2006
Matrix protein of Vesicular stomatitis virus harbours a cryptic mitochondrial-targeting motif. The Journal of general virology\| PubMed ID: 17030873	2006
Effects of intravenously administered recombinant vesicular stomatitis virus (VSV(deltaM51)) on multifocal and invasive gliomas. Journal of the National Cancer Institute\| PubMed ID: 17077357	2006
Carrier cell-based delivery of an oncolytic virus circumvents antiviral immunity. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 17164783	2007
Novel therapeutic target: the PERKs of inhibiting the integrated stress response. Cell cycle (Georgetown, Tex.)\| PubMed ID: 17218786	2006
Cell-based delivery of oncolytic viruses: a new strategic alliance for a biological strike against cancer. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 17264852	2007
Oncolytic viruses: what's next? Current cancer drug targets\| PubMed ID: 17346103	2007
Radioiodide imaging and radiovirotherapy of multiple myeloma using VSV(Delta51)-NIS, an attenuated vesicular stomatitis virus encoding the sodium iodide symporter gene. Blood\| PubMed ID: 17515401	2007
Targeted inflammation during oncolytic virus therapy severely compromises tumor blood flow. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 17579581	2007
Intercellular trafficking of VP22, a herpes simplex virus type 1 tegument protein. Iranian biomedical journal\| PubMed ID: 18051705	2007
Matrix protein mediated shutdown of host cell metabolism limits vesicular stomatitis virus-induced interferon-alpha responses to plasmacytoid dendritic cells. Immunobiology\| PubMed ID: 18086387	2007
Innate immunity, tumor microenvironment and oncolytic virus therapy: friends or foes? Current opinion in molecular therapeutics\| PubMed ID: 18228179	2008
Translational control of the innate immune response through IRF-7. Nature\| PubMed ID: 18272964	2008
Oncolytic efficacy of recombinant vesicular stomatitis virus and myxoma virus in experimental models of rhabdoid tumors. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18281557	2008
Complex rearrangement of chromosomes 19, 21, and 22 in Ewing sarcoma involving a novel reciprocal inversion-insertion mechanism of EWS-ERG fusion gene formation: a case analysis and literatu... Cancer genetics and cytogenetics\| PubMed ID: 18295659	2008
Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: a phase I trial. The lancet oncology\| PubMed ID: 18495536	2008
Translation of targeted oncolytic virotherapeutics from the lab into the clinic, and back again: a high-value iterative loop. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 18500240	2008
Oncolytic vesicular stomatitis viruses are potent agents for intravesical treatment of high-risk bladder cancer. Cancer research\| PubMed ID: 18559493	2008
A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 18560417	2008
Efficacy of systemically administered mutant vesicular stomatitis virus (VSVDelta51) combined with radiation for nasopharyngeal carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18676763	2008
Development of targeted oncolytic virotherapeutics through translational research. Expert opinion on biological therapy\| PubMed ID: 18694356	2008
Chemical targeting of the innate antiviral response by histone deacetylase inhibitors renders refractory cancers sensitive to viral oncolysis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18815361	2008
The p14 FAST protein of reptilian reovirus increases vesicular stomatitis virus neuropathogenesis. Journal of virology\| PubMed ID: 18971262	2009
MicroRNAs fine-tune oncolytic viruses. Nature biotechnology\| PubMed ID: 19060871	2008
Diplomatic immunity: turning a foe into an ally. Current opinion in molecular therapeutics\| PubMed ID: 19169955	2009
Efficacy of systemically administered oncolytic vaccinia virotherapy for malignant gliomas is enhanced by combination therapy with rapamycin or cyclophosphamide. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19351762	2009
Antiangiogenic arming of an oncolytic vaccinia virus enhances antitumor efficacy in renal cell cancer models. Journal of virology\| PubMed ID: 19906926	2010
Down-regulation of type I interferon receptor sensitizes bladder cancer cells to vesicular stomatitis virus-induced cell death. International journal of cancer. Journal international du cancer\| PubMed ID: 19957332	2010
Intelligent design: combination therapy with oncolytic viruses. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 20029399	2010
Intravenously administered alphavirus vector VA7 eradicates orthotopic human glioma xenografts in nude mice. PloS one\| PubMed ID: 20066051	2010
Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20080710	2010
Potent oncolytic activity of raccoonpox virus in the absence of natural pathogenicity. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 20160706	2010
Novel oncolytic viruses: riding high on the next wave? Cytokine & growth factor reviews\| PubMed ID: 20219409	2010
United virus: the oncolytic tag-team against cancer! Cytokine & growth factor reviews\| PubMed ID: 20227326	2010
Synergistic interaction between oncolytic viruses augments tumor killing. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 20234341	2010
Double trouble for tumours: exploiting the tumour microenvironment to enhance anticancer effect of oncolytic viruses. Cytokine & growth factor reviews\| PubMed ID: 20338801	2010
A high-throughput pharmacoviral approach identifies novel oncolytic virus sensitizers. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 20389287	2010
Navigating the clinical development landscape for oncolytic viruses and other cancer therapeutics: no shortcuts on the road to approval. Cytokine & growth factor reviews\| PubMed ID: 20472490	2010
Identification of genetically modified Maraba virus as an oncolytic rhabdovirus. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 20551913	2010
Oncolytic targeting of renal cell carcinoma via encephalomyocarditis virus. EMBO molecular medicine\| PubMed ID: 20623734	2010
Efficacy and safety/toxicity study of recombinant vaccinia virus JX-594 in two immunocompetent animal models of glioma. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 20808290	2010
Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors. PloS one\| PubMed ID: 21283510	2010
Targeting tumor vasculature with an oncolytic virus. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21364541	2011
Sequential therapy with JX-594, a targeted oncolytic poxvirus, followed by sorafenib in hepatocellular carcinoma: preclinical and clinical demonstration of combination efficacy. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21427706	2011
Thunder and lightning: immunotherapy and oncolytic viruses collide. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21505424	2011
Chromosomal position effects are linked to sir2-mediated variation in transcriptional burst size. Biophysical journal\| PubMed ID: 21575565	2011
Viral quantitative capillary electrophoresis for counting intact viruses. Analytical chemistry\| PubMed ID: 21599011	2011
Targeted and Armed Oncolytic Poxviruses for Cancer: The Lead Example of JX-594. Current pharmaceutical biotechnology\| PubMed ID: 21740365	2011
A mechanistic proof-of-concept clinical trial with JX-594, a targeted multi-mechanistic oncolytic poxvirus, in patients with metastatic melanoma. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21772252	2011
Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans. Nature\| PubMed ID: 21886163	2011
A selectable and excisable marker system for the rapid creation of recombinant poxviruses. PloS one\| PubMed ID: 21931792	2011
Interfering with tumor pathways that augment viral oncolysis. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 22134743	2011
Oncolytic viruses: smart therapeutics for smart cancers. Future oncology (London, England)\| PubMed ID: 22149027	2012
Suppression of PKR promotes network excitability and enhanced cognition by interferon-Î³-mediated disinhibition. Cell\| PubMed ID: 22153080	2011
Sensitivity of cervical carcinoma cells to vesicular stomatitis virus-induced oncolysis: Potential role of human papilloma virus infection. International journal of cancer. Journal international du cancer\| PubMed ID: 22173567	2011
The Oncolytic Poxvirus JX-594 Selectively Replicates in and Destroys Cancer Cells Driven by Genetic Pathways Commonly Activated in Cancers. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 22186794	2011
Electrochemical sensing of aptamer-facilitated virus immunoshielding. Analytical chemistry\| PubMed ID: 22242920	2012
ORFV: A Novel Oncolytic and Immune Stimulating Parapoxvirus Therapeutic. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 22273579	2012
Aptamer-Based Viability Impedimetric Sensor for Viruses. Analytical chemistry\| PubMed ID: 22303883	2012
Electrochemical Differentiation of Epitope-Specific Aptamers. Analytical chemistry\| PubMed ID: 22324738	2012