Guri Giaever

Guri Giaever

Donnelly Centre for Cellular and Biomolecular Research, University of Toronto

Affiliated withUniversity of Toronto

Research Area

Biology

Biography

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JoVE Journal Publications

ArticleTotal : 1
Year
Competitive Genomic Screens of Barcoded Yeast Libraries
Publication title

Cited by 44

2011

Other Publications

Article
Year
Transcriptional response of Saccharomyces cerevisiae to DNA-damaging agents does not identify the genes that protect against these agents.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 12077312

2002
Systematic screen for human disease genes in yeast.

Nature genetics| PubMed ID: 12134146

2002
Functional profiling of the Saccharomyces cerevisiae genome.

Nature| PubMed ID: 12140549

2002
"Chemogenomics: tools for protein families" and "Chemical genomics: chemical and biological integration".

Pharmacogenomics| PubMed ID: 12517281

2003
A chemical genomics approach to understanding drug action.

Trends in pharmacological sciences| PubMed ID: 12967766

2003
Chemogenomic profiling: identifying the functional interactions of small molecules in yeast.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 14718668

2004
Noise minimization in eukaryotic gene expression.

PLoS biology| PubMed ID: 15124029

2004
Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast.

Genetics| PubMed ID: 15716499

2005
Functional genomic analysis of the rates of protein evolution.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 15800036

2005
A latent variable model for chemogenomic profiling.

Bioinformatics (Oxford, England)| PubMed ID: 15919724

2005
Genome-wide requirements for resistance to functionally distinct DNA-damaging agents.

PLoS genetics| PubMed ID: 16121259

2005
A unique and universal molecular barcode array.

Nature methods| PubMed ID: 16862133

2006
Experimental approaches to identify genetic networks.

Current opinion in biotechnology| PubMed ID: 16962766

2006
Chemical genomic profiling for identifying intracellular targets of toxicants producing Parkinson's disease.

Toxicological sciences : an official journal of the Society of Toxicology| PubMed ID: 17043098

2007
Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions.

Nature genetics| PubMed ID: 17206143

2007
Accelerating the discovery of biologically active small molecules using a high-throughput yeast halo assay.

Journal of natural products| PubMed ID: 17291044

2007
Identification of genes involved in the toxic response of Saccharomyces cerevisiae against iron and copper overload by parallel analysis of deletion mutants.

Toxicological sciences : an official journal of the Society of Toxicology| PubMed ID: 17785683

2008
Examining protein protein interactions using endogenously tagged yeast arrays: the cross-and-capture system.

Genome research| PubMed ID: 17989249

2007
Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures.

Nature protocols| PubMed ID: 18007632

2007
Defining genetic interaction.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 18305163

2008
Chemical-genetic approaches for exploring the mode of action of natural products.

Progress in drug research. Fortschritte der Arzneimittelforschung. Progrès des recherches pharmaceutiques| PubMed ID: 18416308

2008
The chemical genomic portrait of yeast: uncovering a phenotype for all genes.

Science (New York, N.Y.)| PubMed ID: 18420932

2008
Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen.

PLoS genetics| PubMed ID: 18454192

2008
The extensive and condition-dependent nature of epistasis among whole-genome duplicates in yeast.

Genome research| PubMed ID: 18463300

2008
An integrated platform of genomic assays reveals small-molecule bioactivities.

Nature chemical biology| PubMed ID: 18622389

2008
Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers.

Nature methods| PubMed ID: 18622398

2008
Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast.

PLoS genetics| PubMed ID: 18688276

2008
Yeast chemical genomics and drug discovery: an update.

Trends in pharmacological sciences| PubMed ID: 18755517

2008
Combination chemical genetics.

Nature chemical biology| PubMed ID: 18936752

2008
Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells.

PLoS genetics| PubMed ID: 19043571

2008
Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis.

BMC microbiology| PubMed ID: 19144191

2009
Knocking sense into regulatory pathways.

Nature biotechnology| PubMed ID: 19204694

2009
Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis.

PLoS genetics| PubMed ID: 19300474

2009
Novel insights into iron metabolism by integrating deletome and transcriptome analysis in an iron deficiency model of the yeast Saccharomyces cerevisiae.

BMC genomics| PubMed ID: 19321002

2009
Precise gene-dose alleles for chemical genetics.

Genetics| PubMed ID: 19332878

2009
A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds.

Nature biotechnology| PubMed ID: 19349972

2009
Chemogenomic approaches to elucidation of gene function and genetic pathways.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 19521822

2009
Quantitative phenotyping via deep barcode sequencing.

Genome research| PubMed ID: 19622793

2009
A comparative analysis of DNA barcode microarray feature size.

BMC genomics| PubMed ID: 19825181

2009
The genetic landscape of a cell.

Science (New York, N.Y.)| PubMed ID: 20093466

2010
Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action.

Genome biology| PubMed ID: 20226027

2010
Genotype to phenotype: a complex problem.

Science (New York, N.Y.)| PubMed ID: 20413493

2010
Highly-multiplexed barcode sequencing: an efficient method for parallel analysis of pooled samples.

Nucleic acids research| PubMed ID: 20460461

2010
A universal TagModule collection for parallel genetic analysis of microorganisms.

Nucleic acids research| PubMed ID: 20494978

2010
A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans.

Nature chemical biology| PubMed ID: 20512140

2010
A survey of yeast genomic assays for drug and target discovery.

Pharmacology & therapeutics| PubMed ID: 20546776

2010
Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation.

PLoS genetics| PubMed ID: 20657825

2010
Exploring gene function and drug action using chemogenomic dosage assays.

Methods in enzymology| PubMed ID: 20946813

2010
Gene annotation and drug target discovery in Candida albicans with a tagged transposon mutant collection.

PLoS pathogens| PubMed ID: 20949076

2010
Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection.

Nature methods| PubMed ID: 21217751

2011
Systematic exploration of essential yeast gene function with temperature-sensitive mutants.

Nature biotechnology| PubMed ID: 21441928

2011
The synthetic genetic interaction network reveals small molecules that target specific pathways in Sacchromyces cerevisiae.

Molecular bioSystems| PubMed ID: 21487606

2011
A comprehensive platform for highly multiplexed mammalian functional genetic screens.

BMC genomics| PubMed ID: 21548937

2011
Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell.

Nature biotechnology| PubMed ID: 21572441

2011
Design, synthesis, and characterization of a highly effective Hog1 inhibitor: a powerful tool for analyzing MAP kinase signaling in yeast.

PloS one| PubMed ID: 21655328

2011
Design, synthesis and characterization of a highly effective inhibitor for analog-sensitive (as) kinases.

PloS one| PubMed ID: 21698101

2011
New azole antifungal agents with novel modes of action: synthesis and biological studies of new tridentate ligands based on pyrazole and triazole.

European journal of medicinal chemistry| PubMed ID: 21723647

2011
The automated cell: compound and environment screening system (ACCESS) for chemogenomic screening.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 21863492

2011
Displaying chemical information on a biological network using Cytoscape.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 21877291

2011
Curcumin inhibits growth of Saccharomyces cerevisiae through iron chelation.

Eukaryotic cell| PubMed ID: 21908599

2011
A systems biology approach reveals the role of a novel methyltransferase in response to chemical stress and lipid homeostasis.

PLoS genetics| PubMed ID: 22028670

2011
Compound prioritization methods increase rates of chemical probe discovery in model organisms.

Chemistry & biology| PubMed ID: 22035796

2011
Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans.

Nature chemical biology| PubMed ID: 22057127

2011
Systematic exploration of synergistic drug pairs.

Molecular systems biology| PubMed ID: 22068327

2011
Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia.

Cancer cell| PubMed ID: 22094260

2011
Multiple means to the same end: the genetic basis of acquired stress resistance in yeast.

PLoS genetics| PubMed ID: 22102822

2011
Bugs, drugs and chemical genomics.

Nature chemical biology| PubMed ID: 22173359

2012
Mitochondrial electron transport is the cellular target of the oncology drug elesclomol.

PloS one| PubMed ID: 22253786

2012
Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans.

Nature chemical biology| PubMed ID: 22337098

2012
A global perspective of the genetic basis for carbonyl stress resistance.

G3 (Bethesda, Md.)| PubMed ID: 22384333

2011
Identification of yeast genes that confer resistance to chitosan oligosaccharide (COS) using chemogenomics.

BMC genomics| PubMed ID: 22727066

2012
A novel calcineurin-independent activity of cyclosporin A in Saccharomyces cerevisiae.

Molecular bioSystems| PubMed ID: 22751784

2012
Barcode sequencing for understanding drug-gene interactions.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 22821592

2012
Comparative chemogenomics to examine the mechanism of action of dna-targeted platinum-acridine anticancer agents.

ACS chemical biology| PubMed ID: 22928710

2012
Global gene deletion analysis exploring yeast filamentous growth.

Science (New York, N.Y.)| PubMed ID: 22984072

2012
An algorithm for chemical genomic profiling that minimizes batch effects: bucket evaluations.

BMC bioinformatics| PubMed ID: 23009392

2012
Genome-wide analysis of intracellular pH reveals quantitative control of cell division rate by pH(c) in Saccharomyces cerevisiae.

Genome biology| PubMed ID: 23021432

2012
Functional analysis with a barcoder yeast gene overexpression system.

G3 (Bethesda, Md.)| PubMed ID: 23050238

2012
A phenotypic screening platform to identify small molecule modulators of Chlamydomonas reinhardtii growth, motility and photosynthesis.

Genome biology| PubMed ID: 23158586

2012
Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors.

The Journal of clinical investigation| PubMed ID: 23202731

2013
Chromatin is an ancient innovation conserved between Archaea and Eukarya.

eLife| PubMed ID: 23240084

2012
Global analysis of SUMO chain function reveals multiple roles in chromatin regulation.

The Journal of cell biology| PubMed ID: 23547032

2013
DNA-damaging agents in cancer chemotherapy: serendipity and chemical biology.

Chemistry & biology| PubMed ID: 23706631

2013
A high-throughput yeast assay identifies synergistic drug combinations.

Assay and drug development technologies| PubMed ID: 23772551

2013
Miniature short hairpin RNA screens to characterize antiproliferative drugs.

G3 (Bethesda, Md.)| PubMed ID: 23797109

2013
A novel small molecule methyltransferase is important for virulence in Candida albicans.

ACS chemical biology| PubMed ID: 24083538

2013
PITPs as targets for selectively interfering with phosphoinositide signaling in cells.

Nature chemical biology| PubMed ID: 24292071

2014
Large-scale identification and analysis of suppressive drug interactions.

Chemistry & biology| PubMed ID: 24704506

2014
Mapping the cellular response to small molecules using chemogenomic fitness signatures.

Science (New York, N.Y.)| PubMed ID: 24723613

2014
A genome scale overexpression screen to reveal drug activity in human cells.

Genome medicine| PubMed ID: 24944581

2014
Genes required for survival in microgravity revealed by genome-wide yeast deletion collections cultured during spaceflight.

BioMed research international| PubMed ID: 25667933

2015
Caenorhabditis elegans is a useful model for anthelmintic discovery.

Nature communications| PubMed ID: 26108372

2015
Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death.

Oncotarget| PubMed ID: 26353928

2015
Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles.

ACS central science| PubMed ID: 27800551

2016