Corey Nislow

Corey Nislow

Banting and Best Department of Medical Research and Department of Molecular Genetics, University of Toronto

Affiliated withUniversity of Toronto

Research Area

Biography

Dr. Nislow completed a Bachelor of Arts in developmental biology at New College (Sarasota, Florida) and a Doctor of Philosophy in cell and molecular biology at the University of Colorado (Boulder, Colorado). Dr. Corey Nislow is an Associate Professor in the Faculty of Pharmaceutical Sciences, a Co-Founder and Director of the Sequencing + Bioinformatics Consortium, and an Advisor to the Advanced Research Computing group all at the University of British Columbia, as well as a Co-Founder of Genetic Networks LLC. Formerly, he served as group leader in two biotechnology companies (MJ Research and Cytokinetics Inc., in the San Francisco Bay Area) and as a Senior Genome Scientist at Stanford University. He was also an Associate Professor at the University of Toronto and Director of the Donnelly Sequencing Centre.

Dr. Nislow is a cell biologist and geneticist whose lab employs genomics and develops biotechnology tools to address both fundamental and applied biological questions using technologies such as parallel genome-wide chemical genomic screens, high throughput cell-based screens, and next generation sequencing. His research program has developed and deployed an array of chemical genomic tools for systems biology including protocols to perform genome wide screens on the International Space Station to which he has launched 4 science missions. He is the lead researcher for the Genomics for Precision Drug Therapy in the Community Pharmacy a first-in-Canada trial that empowers patients to directly access their genome data for medication management. Dr. Nislow has been involved in a few notable scientific projects; cloning the first human mitotic kinesin, identifying the founding member of the SET family of chromatin modifiers, and produced the first comprehensive genome-wide map of nucleosome occupancy in an organism.

Dr. Nislow is an accomplished academic with 170 peer-reviewed publications and 6 patents, as well as an enthusiastic instructor that enjoys teaching all aspects of biotechnology, genomics, and drug discovery for students and trainees.

JoVE Journal Publications

ArticleTotal : 1
Year
Competitive Genomic Screens of Barcoded Yeast Libraries
Publication title

Cited by 44

2011

Other Publications

Article
Year
"Chemogenomics: tools for protein families" and "Chemical genomics: chemical and biological integration".

Pharmacogenomics| PubMed ID: 12517281

2003
Chemogenomic profiling: identifying the functional interactions of small molecules in yeast.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 14718668

2004
2005
2005
2006
A unique and universal molecular barcode array.

Nature methods| PubMed ID: 16862133

2006
Experimental approaches to identify genetic networks.

Current opinion in biotechnology| PubMed ID: 16962766

2006
Chemical genomic profiling for identifying intracellular targets of toxicants producing Parkinson's disease.

Toxicological sciences : an official journal of the Society of Toxicology| PubMed ID: 17043098

2007
2007
2007
2008
2007
2007
2007
Chemical-genetic approaches for exploring the mode of action of natural products.

Progress in drug research. Fortschritte der Arzneimittelforschung. Progrès des recherches pharmaceutiques| PubMed ID: 18416308

2008
2008
2008
2008
2008
2008
2008
Yeast chemical genomics and drug discovery: an update.

Trends in pharmacological sciences| PubMed ID: 18755517

2008
Combination chemical genetics.

Nature chemical biology| PubMed ID: 18936752

2008
2008
2008
2009
Knocking sense into regulatory pathways.

Nature biotechnology| PubMed ID: 19204694

2009
2009
2009
2009
2009
Self-reporting cells.

BioTechniques| PubMed ID: 19480631

2009
Chemogenomic approaches to elucidation of gene function and genetic pathways.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 19521822

2009
2009
Quantitative phenotyping via deep barcode sequencing.

Genome research| PubMed ID: 19622793

2009
2009
2009
You too can play with an edge.

Nature methods| PubMed ID: 19876015

2009
Recent advances and method development for drug target identification.

Trends in pharmacological sciences| PubMed ID: 20004028

2010
2010
The genetic landscape of a cell.

Science (New York, N.Y.)| PubMed ID: 20093466

2010
2010
Genotype to phenotype: a complex problem.

Science (New York, N.Y.)| PubMed ID: 20413493

2010
2010
2010
2010
2010
A survey of yeast genomic assays for drug and target discovery.

Pharmacology & therapeutics| PubMed ID: 20546776

2010
2010
2010
2010
2010
2010
2011
2011
2011
2011
2011
2011
2011
2011
2011
2011
2011
2011
Displaying chemical information on a biological network using Cytoscape.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 21877291

2011
2011
2011
2011
2011
2011
2011
Systematic exploration of synergistic drug pairs.

Molecular systems biology| PubMed ID: 22068327

2011
2011
2011
2011
Bugs, drugs and chemical genomics.

Nature chemical biology| PubMed ID: 22173359

2012
Genomic approaches for determining nucleosome occupancy in yeast.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 22183606

2012
2012
2012
2012
2011
Genome sequence of Shigella flexneri serotype 5a strain M90T Sm.

Journal of bacteriology| PubMed ID: 22582379

2012
2012
2012
Barcode sequencing for understanding drug-gene interactions.

Methods in molecular biology (Clifton, N.J.)| PubMed ID: 22821592

2012
2012
2012
Global gene deletion analysis exploring yeast filamentous growth.

Science (New York, N.Y.)| PubMed ID: 22984072

2012
2012
2012
2012
2013
2012
2012
2013
2013
2012
2013
2013
2013
2013
2013
A high-throughput yeast assay identifies synergistic drug combinations.

Assay and drug development technologies| PubMed ID: 23772551

2013
2013
2013
A unified model for yeast transcript definition.

Genome research| PubMed ID: 24170600

2014
2014
2014
2014
2014
2014
2014
2014
2014
2015
2015
2015
2015
2016
2016