isolation-propagation-prion-protein-expression-during-neuronal

Isolation, Propagation, and Prion Protein Expression During Neuronal Differentiation of Human Dental Pulp Stem Cells

Bioethical issues related to the manipulation of embryonic stem cells have hindered advances in the field of medical research. For this reason, it is very ...

Sapienza University of Rome

The brass wire ligature is an efficient method to correct a moderately mesially impacted mandibular second molar (MM2). The aim of this prospective clinical pilot study was to evaluate the influence of mandibular third molar (MM3) germectomy on the treatment time for this procedure and to determine its impact on oral health-related quality of life (OHRQoL) using the short-form Oral Health Impact Profile (OHIP-14). The STROBE guidelines were followed. Impacted MM2 were assigned randomly to receive brass wire ligature treatment either with germectomy (group A) or without germectomy (group B). Descriptive statistics and the Student t-test were used in the statistical analysis; significance was set at P≤0.05. One thousand and thirty patients were assessed. Fourteen subjects with 20 mesially angulated (range 25-40°) impacted MM2 were identified. Paired comparisons of groups A and B showed no statistically significant difference in treatment time (171days for group A and 174days for group B; P=0.440), but a statistically significant difference in OHIP-14 values at the 3- (P=0.017) and 7-day (P=0.002) follow-up. The brass wire technique can be used effectively in moderately impacted MM2, but the combined use of MM3 germectomy does not influence the treatment time and shows a negative impact on OHRQoL.

The influence of mandibular third molar germectomy on the treatment time of impacted mandibular second molars using brass wire: a prospective clinical pilot study.

The aim of this report was to describe a new computer-guided technique for a controlled site preparation and palatal orthodontic miniscrew insertion using a dedicated software. A surgical guide was designed after planning the appropriate insertion sites on three-dimensional images created by the fusion of cone-beam computed tomography (CBCT) and digital dental model images. Pre- and postoperative CBCT images were compared and the angular, coronal, and apical deviations between the planned and the placed miniscrews were calculated. The mean coronal and apical deviations were 1.38mm (range: 3.48-0.15mm; standard deviation (SD): 0.65) and 1.73mm (range: 5.41-0.10mm; SD: 1.03), respectively, while the mean angular deviation was 4.60° (range: 15.23-0.54°; SD: 2.54). The present surgical guide allows a controlled and accurate palatal miniscrew placement in three dimensions.

Palatal orthodontic miniscrew insertion using a CAD-CAM surgical guide: description of a technique.

This study was performed to evaluate the reliability of peri-apical radiographs in determining peri-implant marginal bone level changes. The STROBE guidelines were followed. Marginal bone levels were measured at the time of implant insertion using a straight periodontal probe and using peri-apical radiographs. These intraoperative and radiographic measurements were repeated at the time of second surgery. All radiographs were analysed by two examiners blinded to the intraoperative measurements. To standardize the radiographic images, the long-cone parallel technique and a film-holding system were used. Intra-observer agreement and inter-observer variability were assessed using the intra-class correlation coefficient (ICC). Descriptive statistics, the t-test, and the Pearson correlation coefficient were also used. A total of 268 implants were inserted in 142 patients. Inter-observer agreement was 0.950; intra-observer variability was 0.980 and 0.973. The mean difference between the radiographic and intraoperative measurements was 0.50±1.55mm (range 0-8mm); the difference was statistically significant (P=0.000). A significant linear correlation was found between the marginal bone level changes evaluated intraoperatively and radiographically (P<0.005). Radiographic analysis significantly overestimated the level of peri-implant marginal bone compared to intraoperative measurements, but peri-apical radiographs are reliable in determining the bone level changes at different follow-ups.

Are intraoral radiographs reliable in determining peri-implant marginal bone level changes? The correlation between open surgical measurements and peri-apical radiographs.

Article	Year
The influence of mandibular third molar germectomy on the treatment time of impacted mandibular second molars using brass wire: a prospective clinical pilot study. International journal of oral and maxillofacial surgery\| PubMed ID: 28408148	2017
Palatal orthodontic miniscrew insertion using a CAD-CAM surgical guide: description of a technique. International journal of oral and maxillofacial surgery\| PubMed ID: 29653870	2018
Are intraoral radiographs reliable in determining peri-implant marginal bone level changes? The correlation between open surgical measurements and peri-apical radiographs. International journal of oral and maxillofacial surgery\| PubMed ID: 29866412	2018

Michele Cassetta

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