precision-measurements-and-parametric-models-of-vertebral-endplates

Precision Measurements and Parametric Models of Vertebral Endplates

Detailed and comprehensive geometric data of vertebrae endplates is important and necessary to improve the fidelity of finite element models of the spine, ...

Tongji University School of Medicine

Box cages packed with local decompression bone were efficient in anterior cervical discectomy and fusion: five- to 10-year follow-up.

A schwannoma is a benign tumor arising from a schwann cell and occurs mainly in the nerve sheath in the intradural extramedullary region. Schwannomas have been well described as occurring in the lumbar spine, but total cystic degeneration of schwannomas is rarely reported. The authors describe the clinical and radiographic evaluations and treatment of a rare case of an intraextradural totally cystic schwannoma on the lumbar spine.Two patients reported a history of 6 to 12 months of pain accompanied by weakness in the lower extremities. On examination, 1 patient had bilateral lower-extremity muscle strength graded at 4/5, and magnetic resonance imaging revealed a cystic schwannoma (1.5Ã—2.0 cm in the sagittal dimension) at L2-L3. The other patient had a right lower-extremity muscle strength graded at 3/5, and magnetic resonance imaging revealed a cystic schwannoma (2.0Ã—3.0 cm in the sagittal dimension) at L4-L5. The patients underwent operative treatment, and the tumors were completely removed, as were the filum terminale adhered to the tumor. Pedicle screws were used to maintain stability of the lumbar spine. Gross examination of the tumors showed yellowish-white soft contents. Histologic examination confirmed that they were benign totally cystic schwannomas. Postoperatively, the patients' neurologic symptoms completely resolved.Cystic schwannomas can be diagnosed using preoperative magnetic resonance imaging. The filum terminale cut off the tumor walls did not cause the clinical symptoms in the 2 patients.

Totally Cystic Schwannoma of the Lumbar Spine.

Un Schwannome est une tumeur b&eacute;nigne r&eacute;sultant d&#39;une cellule de schwann et se produit principalement dans la gaine des nerfs dans la r&eacute;gion d&#39;extram&eacute;dullaire intradural. Les schwannomes ont &eacute;t&eacute; bien d&eacute;crites comme &eacute;tant pr&eacute;sents dans la colonne lombaire, mais totale d&eacute;g&eacute;n&eacute;rescence kystique des schwannomes est rarement rapport&eacute;e. Les auteurs d&eacute;crivent les &eacute;valuations cliniques et radiographiques et traitement d&#39;un cas rare d&#39;un Schwannome totalement kystique d&#39;intraextradural sur la colonne lombaire.Deux patients ont rapport&eacute; une histoire de 6 &agrave; 12 mois de douleur accompagn&eacute;e par une faiblesse dans les membres inf&eacute;rieurs. &Agrave; l&#39;examen, 1 patient a force musculaire bilat&eacute;rale de bas-extr&eacute;mit&eacute; class&eacute;e &agrave; 4/5, et l&#39;imagerie par r&eacute;sonance magn&eacute;tique a r&eacute;v&eacute;l&eacute; un Schwannome kystique (1,5 &times; 2.0 cm &agrave; la dimension sagittale) &agrave; L2-L3. L&#39;autre patient avait une force de muscle de bas-extr&eacute;mit&eacute; droite not&eacute;e 3/5, et l&#39;imagerie par r&eacute;sonance magn&eacute;tique a r&eacute;v&eacute;l&eacute; un Schwannome kystique (2.0 &times; 3.0 cm &agrave; la dimension sagittale) &agrave; L4-L5. Les patients ont &eacute;t&eacute; trait&eacute;s du dispositif et les tumeurs ont &eacute;t&eacute; compl&egrave;tement retir&eacute;es, &eacute;tant donn&eacute; que le filum terminale ont adh&eacute;r&eacute; &agrave; la tumeur. Vis de p&eacute;dicule servaient &agrave; maintenir la stabilit&eacute; de la colonne lombaire. Examen brut des tumeurs a contenu doux blanc jaun&acirc;tre. L&#39;examen histologique a confirm&eacute; qu&#39;il s&#39;agissait des schwannomes totalement kystiques b&eacute;nignes. Apr&egrave;s l&#39;op&eacute;ration, sympt&ocirc;mes des patients neurologiques compl&egrave;tement r&eacute;solues.Schwannomes kystiques peuvent &ecirc;tre diagnostiqu&eacute;s &agrave; l&#39;aide de l&#39;imagerie par r&eacute;sonance magn&eacute;tique pr&eacute;op&eacute;ratoire. Le filum terminale couper les murs de la tumeur n&#39;a pas caus&eacute; les sympt&ocirc;mes cliniques chez les 2 patients.

Schwannome totalement kystique de la colonne lombaire.

Un neurinoma &egrave; un tumore benigno derivante da una cellula di schwann e si verifica principalmente nella guaina nervosa extramidollare intradural della regione. Schwannomi sono state ben descritti come che si verificano nella colonna lombare, ma totale degenerazione cistica di schwannoma raramente &egrave; segnalata. Gli autori descrivono le valutazioni cliniche e radiografiche e trattamento di un caso raro di un neurinoma cistico totalmente intraextradural sulla colonna lombare.Due pazienti ha riferito una storia di 6-12 mesi di dolore accompagnato da debolezza degli arti inferiori. Su esame, 1 paziente aveva forza muscolare bilaterale di arto inferiore, classificata a 4/5, e la risonanza magnetica ha rivelato un neurinoma cistico (1,5 &times; 2.0 cm nella dimensione sagittale) a L2-L3. L&#39;altro paziente ha avuto una forza muscolare destra basso-estremit&agrave; classificato a 3/5, e la risonanza magnetica ha rivelato un neurinoma cistico (2.0 &times; 3.0 cm nella dimensione sagittale) a L4-L5. I pazienti sono stati sottoposti a trattamento operatorio, e i tumori sono stati completamente rimossi, come furono che il filum terminale aderito al tumore. Viti peduncolo sono state utilizzate per mantenere la stabilit&agrave; del rachide lombare. Esame lordo dei tumori ha mostrato contenuto morbido bianco-giallastro. Esame istologico ha confermato che erano schwannomi totalmente cistici benigni. Dopo l&#39;intervento, i pazienti sintomi neurologici completamente risolti.Schwannomi cistici possono essere diagnosticati mediante imaging a risonanza magnetica preoperative. Il filum terminale tagliato fuori le mura di tumore non ha causato i sintomi clinici in 2 pazienti.

Schwannoma totalmente cistica del rachide lombare.

To investigate the clinical outcomes of transforaminal endoscopic system(TESSYS) for discogenic low back pain(DLBP).

Transforaminal endoscopic system technique for discogenic low back pain: A prospective Cohort study.

The dysphagia and recurrent laryngeal nerve (RLN) palsy are the most common complications of the patients who underwent anterior cervical surgery in the current literature. These morbidities have led to the study of the impact of sidedness in anterior cervical spine surgery. However, many reports documented the left-side was more effective and safe than right-side based on the anatomy. So the right-side approach is more challenging. We retrospectively study 503 patients with cervical degenerative diseases who underwent cervical spinal surgery using anterolateral right-side approach in our spine center from September 1999 to December 2012 and evaluate the efficient and safety of the anterolateral right-side approach to treat the cervical degenerative diseases. The overall mortality rate in our present report was 3.38% (17 of 503 patients). The most common complication which observed in 2.80% of our cases was dysphagia. Postoperatively, there was only one patient with hematoma and died (0.19%) and symptomatic recurrent laryngeal nerve palsy occurred in 0.39% of the cases. The anterolateral right-side anterior approach didn't increase the incidence of the dysphagia and recurrent laryngeal nerve (RLN) palsy.

Do the complications increased in the anterolateral right-side approach to treat the cervical degenerative disorders? A retrospective cohort study.

Multivariate analysis of airway obstruction and reintubation after anterior cervical surgery: A Retrospective Cohort Study of 774 patients.

Adjacent segment disease (ASD) is a common complication after lumbar decompression and fusion surgery. Traditional revision-surgery, including posterior lumbar decompression and posterolateral fusion (PLF) or interbody fusion (PLIF) is traumatic. The percutaneous endoscopic transforaminal procedure (PE-TF) has been widely used in patients with lumbar disc disease. However, there are no reports about using PE-TF procedure to treat ASD in the current literature.

Percutaneous endoscopical transforaminal approach versus PLF to treat the single-level adjacent segment disease after PLF/PLIF: 1-2 years follow-up.

Do the complications increased in the anterolateral right-side approach to treat the cervical degenerative disorders?

To describe a modified technique usied for foraminoplasty in percutaneous endoscopic transforaminal procedure.

Eccentric technique for foraminoplasty in percutaneous endoscopic transforaminal procedure: A technical note.

The expression of the core autophagy kinase, Unc51-like kinase 1 (ULK1), is regulated transcriptionally and translationally by starvation-induced autophagy. However, how ULK1 is regulated during hypoxia is not well understood. Previously, we showed that ULK1 expression is induced by hypoxia stress. Here, we report a new ULK1-modulating microRNA, miR-93; its transcription is negatively correlated with the translation of ULK1 under hypoxic condition. miR-93 targets ULK1 and reduces its protein levels under hypoxia condition. miR-93 also inhibits hypoxia-induced autophagy by preventing LC3-I to LC3-II transition and P62 degradation; these processes are reversed by the overexpression of an endogenous miR-93 inhibitor. Re-expression of ULK1 without miR-93 response elements restores the hypoxia-induced autophagy which is inhibited by miR-93. Finally, we detected the effects of miR-93 on cell viability and apoptosis in noncancer cell lines and cancer cells. We found that miR-93 sustains the viability of MEFs (mouse embryonic fibroblasts) and inhibits its apoptosis under hypoxia. Thus, we conclude that miR-93 is involved in hypoxia-induced autophagy by regulating ULK1. Our results provide a new angle to understand the complicated regulation of the key autophagy kinase ULK1 during different stress conditions.

MicroRNA-93 Regulates Hypoxia-Induced Autophagy by Targeting ULK1.

Diabetes mellitus (DM) and low back pain which is mainly caused by degeneration of the intervertebral discs (IVDs) both are major public health problem worldwide. The present study was designed to investigate the association between type 2 diabetes mellitus (T2D) and severity of lumbar disc degeneration (LDD).

The potential effect of type 2 diabetes mellitus on lumbar disc degeneration: a retrospective single-center study.

It is predicted that with increased life expectancy in the whole world, there will be a greater demand for synthetic biomedical materials to repair or regenerate lost, injured or diseased tissues. Natural polymers, as biomedical materials, have been widely applied in the field of regenerative medicine.

Nanoporous diopside modulates biocompatibility, degradability and osteogenesis of bioactive scaffolds of gliadin-based composites for new bone formation.

Accurate and comprehensive data on cervical endplates is essential for developing and improving cervical devices. However, current literature on vertebral disc geometry is scarce or not suitable. The aim of this study was to obtain quantitative parameters of cervical endplates and provide morphometric references for designing cervical devices.

Morphometry evaluations of cervical osseous endplates based on three dimensional reconstructions.

Due to the increasing number of patients with bone defects, bone nonunion and osteo-myelitis, tumor and congenital diseases, bone repair has become an urgent problem to be solved.

3D-printed scaffolds of mesoporous bioglass/gliadin/polycaprolactone ternary composite for enhancement of compressive strength, degradability, cell responses and new bone tissue ingrowth.

Article	Year
Box cages packed with local decompression bone were efficient in anterior cervical discectomy and fusion: five- to 10-year follow-up. Spine\| PubMed ID: 22744617	2012
Totally Cystic Schwannoma of the Lumbar Spine. Orthopedics\| PubMed ID: 23672923	2013
Transforaminal endoscopic system technique for discogenic low back pain: A prospective Cohort study. International journal of surgery (London, England)\| PubMed ID: 27693825	2016
Do the complications increased in the anterolateral right-side approach to treat the cervical degenerative disorders? A retrospective cohort study. International journal of surgery (London, England)\| PubMed ID: 28110025	2017
Multivariate analysis of airway obstruction and reintubation after anterior cervical surgery: A Retrospective Cohort Study of 774 patients. International journal of surgery (London, England)\| PubMed ID: 28315747	2017
Percutaneous endoscopical transforaminal approach versus PLF to treat the single-level adjacent segment disease after PLF/PLIF: 1-2 years follow-up. International journal of surgery (London, England)\| PubMed ID: 28428063	2017
Do the complications increased in the anterolateral right-side approach to treat the cervical degenerative disorders? International journal of surgery (London, England)\| PubMed ID: 28648792	2017
Eccentric technique for foraminoplasty in percutaneous endoscopic transforaminal procedure: A technical note. International journal of surgery (London, England)\| PubMed ID: 28882771	2017
MicroRNA-93 Regulates Hypoxia-Induced Autophagy by Targeting ULK1. Oxidative medicine and cellular longevity\| PubMed ID: 29109831	2017
The potential effect of type 2 diabetes mellitus on lumbar disc degeneration: a retrospective single-center study. Journal of orthopaedic surgery and research\| PubMed ID: 29540205	2018
Nanoporous diopside modulates biocompatibility, degradability and osteogenesis of bioactive scaffolds of gliadin-based composites for new bone formation. International journal of nanomedicine\| PubMed ID: 30013342	2018
Morphometry evaluations of cervical osseous endplates based on three dimensional reconstructions. International orthopaedics\| PubMed ID: 30091068	2019
3D-printed scaffolds of mesoporous bioglass/gliadin/polycaprolactone ternary composite for enhancement of compressive strength, degradability, cell responses and new bone tissue ingrowth. International journal of nanomedicine\| PubMed ID: 30271139	2018

Zhaoyu Ba

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