comprehensive-autopsy-program-for-individuals-with-multiple-sclerosis

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

We describe a rapid tissue donation program for individuals with multiple sclerosis (MS) that requires scientists and technicians to be on-call 24/7, 365 ...

Cleveland Clinic

Magnetic resonance imaging has been crucial in the development of anti-inflammatory disease-modifying treatments. The current landscape of multiple sclerosis clinical trials is currently expanding to include testing not only of anti-inflammatory agents, but also neuroprotective, remyelinating, neuromodulating, and restorative therapies. This is especially true of therapies targeting progressive forms of the disease where neurodegeneration is a prominent feature. Imaging techniques of the brain and spinal cord have rapidly evolved in the last decade to permit in vivo characterization of tissue microstructural changes, connectivity, metabolic changes, neuronal loss, glial activity, and demyelination. Advanced magnetic resonance imaging techniques hold significant promise for accelerating the development of different treatment modalities targeting a variety of pathways in MS.

The Role of Advanced Magnetic Resonance Imaging Techniques in Multiple Sclerosis Clinical Trials.

Neoplasms and reactivation of latent viruses have been observed in individuals taking fingolimod. Merkel cell carcinoma (MCC), a rare neuroendocrine skin cancer, is associated with immunosuppression and can be triggered by the oncogenic Merkel cell polyoma virus (MCPyV). We report a case of a 61-year-old man with multiple sclerosis who developed MCPyV-positive MCC 4 years after starting fingolimod. This is the second report of MCC associated with MCPyV in an individual on fingolimod.

Merkel cell carcinoma with fingolimod treatment for multiple sclerosis: A case report.

Treatment decisions in MS: Shifting the goal posts or changing how we see them?

This case report is of a septuagenarian man on chronic low-dose prednisone who presented with disseminated nocardiosis () that was initially mistaken for metastatic brain cancer. Neurologists should be aware of the potential for opportunistic infections with steroid use and to consider a definite tissue diagnosis with culture and histopathology prior to treatment.

Article	Year
The Role of Advanced Magnetic Resonance Imaging Techniques in Multiple Sclerosis Clinical Trials. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 28770481	2017
Merkel cell carcinoma with fingolimod treatment for multiple sclerosis: A case report. Multiple sclerosis and related disorders\| PubMed ID: 29055440	2017
Treatment decisions in MS: Shifting the goal posts or changing how we see them? Multiple sclerosis (Houndmills, Basingstoke, England)\| PubMed ID: 30234433	2018
Disseminated nocardiosis with cerebral and subcutaneous lesions on low-dose prednisone. Practical neurology\| PubMed ID: 30242096	2019
Brain fibrinogen deposition plays a key role in MS pathophysiology - Yes. Multiple sclerosis (Houndmills, Basingstoke, England)\| PubMed ID: 31315512	2019

Kedar R. Mahajan

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