Bruce D. Trapp

Department of Neurosciences, Cleveland Clinic

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 22	2019

Other Publications

Article	Year
Differentiation and death of premyelinating oligodendrocytes in developing rodent brain. The Journal of cell biology\| PubMed ID: 9128255	1997
Expression of oligodendrocyte progenitor cell antigens by gliomas: implications for the histogenesis of brain tumors. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 10468613	1999
Axonal pathology in multiple sclerosis: relationship to neurologic disability. Current opinion in neurology\| PubMed ID: 10499174	1999
P(0) glycoprotein overexpression causes congenital hypomyelination of peripheral nerves. The Journal of cell biology\| PubMed ID: 10704451	2000
Axo-glial septate junctions. The maestro of nodal formation and myelination? The Journal of cell biology\| PubMed ID: 10931879	2000
Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequences. Current opinion in neurology\| PubMed ID: 11371748	2001
N-acetylaspartate is an axon-specific marker of mature white matter in vivo: a biochemical and immunohistochemical study on the rat optic nerve. Annals of neurology\| PubMed ID: 11782984	2002
Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis. The New England journal of medicine\| PubMed ID: 11796850	2002
Axon loss in the spinal cord determines permanent neurological disability in an animal model of multiple sclerosis. Journal of neuropathology and experimental neurology\| PubMed ID: 11829341	2002
VCAM-1-positive microglia target oligodendrocytes at the border of multiple sclerosis lesions. Journal of neuropathology and experimental neurology\| PubMed ID: 12071637	2002
Treatment of experimental autoimmune encephalomyelitis with the chemokine receptor antagonist Met-RANTES. Journal of neuroimmunology\| PubMed ID: 12098506	2002
The tetraspanin protein, CD9, is expressed by progenitor cells committed to oligodendrogenesis and is linked to beta1 integrin, CD81, and Tspan-2. Glia\| PubMed ID: 12420314	2002
Axonal degeneration and progressive neurologic disability in multiple sclerosis. Neurotoxicity research\| PubMed ID: 12832230	2003
The 36K protein of zebrafish CNS myelin is a short-chain dehydrogenase. Glia\| PubMed ID: 14966869	2004
Dysmyelinated lower motor neurons retract and regenerate dysfunctional synaptic terminals. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15084670	2004
Neuropathobiology of multiple sclerosis. Neurologic clinics\| PubMed ID: 15661090	2005
Beta IV tubulin is selectively expressed by oligodendrocytes in the central nervous system. Glia\| PubMed ID: 15712210	2005
Taking two TRAILS. Neuron\| PubMed ID: 15882629	2005
Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients. Annals of neurology\| PubMed ID: 16392116	2006
Evolution of a neuroprotective function of central nervous system myelin. The Journal of cell biology\| PubMed ID: 16449196	2006
A dual tyrosine-leucine motif mediates myelin protein P0 targeting in MDCK cells. Glia\| PubMed ID: 16788992	2006
N-acetyl-L-aspartate in multiple sclerosis. Advances in experimental medicine and biology\| PubMed ID: 16802714	2006
[Pathology and definition of multiple sclerosis]. La Revue du praticien\| PubMed ID: 16948216	2006
Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases. Journal of neuroimmunology\| PubMed ID: 16983747	2006
Bace1 modulates myelination in the central and peripheral nervous system. Nature neuroscience\| PubMed ID: 17099708	2006
Evidence for synaptic stripping by cortical microglia. Glia\| PubMed ID: 17136771	2007
Pathogenesis of axonal and neuronal damage in multiple sclerosis. Neurology\| PubMed ID: 17548565	2007
Activation of the ciliary neurotrophic factor (CNTF) signalling pathway in cortical neurons of multiple sclerosis patients. Brain : a journal of neurology\| PubMed ID: 17898009	2007
Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 18413858	2008
Rescue of congenital hypomyelination by progenitor cell transplantation. Cell stem cell\| PubMed ID: 18522843	2008
Preconditioning paradigms and pathways in the brain. Cleveland Clinic journal of medicine\| PubMed ID: 18540152	2008
Multiple sclerosis: an immune or neurodegenerative disorder? Annual review of neuroscience\| PubMed ID: 18558855	2008
P0 protein is required for and can induce formation of schmidt-lantermann incisures in myelin internodes. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18614675	2008
Neurogenesis in the chronic lesions of multiple sclerosis. Brain : a journal of neurology\| PubMed ID: 18669500	2008
Imaging correlates of leukocyte accumulation and CXCR4/CXCL12 in multiple sclerosis. Archives of neurology\| PubMed ID: 19139298	2009
Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis. The Lancet. Neurology\| PubMed ID: 19233038	2009
Beta4 tubulin identifies a primitive cell source for oligodendrocytes in the mammalian brain. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19535576	2009
Human myelin proteome and comparative analysis with mouse myelin. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19706548	2009
NG2-positive glia in the human central nervous system. Neuron glia biology\| PubMed ID: 19785924	2009
Gray-matter injury in multiple sclerosis. The New England journal of medicine\| PubMed ID: 19812410	2009
The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination. Nature neuroscience\| PubMed ID: 19838178	2009
Demyelination increases axonal stationary mitochondrial size and the speed of axonal mitochondrial transport. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20463228	2010
Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis. Progress in neurobiology\| PubMed ID: 20946934	2011
Gene expression profiling in multiple sclerosis brain. Neurobiology of disease\| PubMed ID: 21147224	2012
Demyelination causes synaptic alterations in hippocampi from multiple sclerosis patients. Annals of neurology\| PubMed ID: 21446020	2011
Cleavage of neuregulin-1 by BACE1 or ADAM10 protein produces differential effects on myelination. The Journal of biological chemistry\| PubMed ID: 21576249	2011
Myelination and axonal electrical activity modulate the distribution and motility of mitochondria at CNS nodes of Ranvier. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21593309	2011
Increased mitochondrial content in remyelinated axons: implications for multiple sclerosis. Brain : a journal of neurology\| PubMed ID: 21705418	2011
Lipopolysaccharide-induced microglial activation and neuroprotection against experimental brain injury is independent of hematogenous TLR4. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22915113	2012
Cortical remyelination: a new target for repair therapies in multiple sclerosis. Annals of neurology\| PubMed ID: 23076662	2012
Clinically feasible MTR is sensitive to cortical demyelination in MS. Neurology\| PubMed ID: 23269598	2013
Lessons from Jack Griffin and the "pathogenesis of peripheral nerve disease". Journal of the peripheral nervous system : JPNS\| PubMed ID: 23279427	2012
High spatial and angular resolution diffusion-weighted imaging reveals forniceal damage related to memory impairment. Magnetic resonance imaging\| PubMed ID: 23295147	2013
Hippocampal demyelination and memory dysfunction are associated with increased levels of the neuronal microRNA miR-124 and reduced AMPA receptors. Annals of neurology\| PubMed ID: 23595422	2013
Activated microglia enhance neurogenesis via trypsinogen secretion. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23650361	2013
Biology of Schwann cells. Handbook of clinical neurology\| PubMed ID: 23931775	2013
Act1 mediates IL-17-induced EAE pathogenesis selectively in NG2+ glial cells. Nature neuroscience\| PubMed ID: 23995070	2013
Epigenome-wide differences in pathology-free regions of multiple sclerosis-affected brains. Nature neuroscience\| PubMed ID: 24270187	2014
Axonal loss in multiple sclerosis: causes and mechanisms. Handbook of clinical neurology\| PubMed ID: 24507515	2014
Hippocampal volume is related to cognitive decline and fornicial diffusion measures in multiple sclerosis. Magnetic resonance imaging\| PubMed ID: 24512796	2014
Relapsing and progressive forms of multiple sclerosis: insights from pathology. Current opinion in neurology\| PubMed ID: 24722325	2014
Mitochondrial immobilization mediated by syntaphilin facilitates survival of demyelinated axons. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24958879	2014
Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain. Nature communications\| PubMed ID: 25047355	2014
Proteolipid protein cannot replace P0 protein as the major structural protein of peripheral nervous system myelin. Glia\| PubMed ID: 25066805	2015
Discrepancy in CCL2 and CCR2 expression in white versus grey matter hippocampal lesions of Multiple Sclerosis patients. Acta neuropathologica communications\| PubMed ID: 25149422	2014
Mitochondrial fission augments capsaicin-induced axonal degeneration. Acta neuropathologica\| PubMed ID: 25322817	2015
Microglia and neuroprotection. Journal of neurochemistry\| PubMed ID: 25693054	2016
Cuprizone does not induce CNS demyelination in nonhuman primates. Annals of clinical and translational neurology\| PubMed ID: 25750925	2015
Pathological mechanisms in progressive multiple sclerosis. The Lancet. Neurology\| PubMed ID: 25772897	2015
Astrocyte response to IFN-γ limits IL-6-mediated microglia activation and progressive autoimmune encephalomyelitis. Journal of neuroinflammation\| PubMed ID: 25896970	2015
The relationship between cognitive function and high-resolution diffusion tensor MRI of the cingulum bundle in multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England)\| PubMed ID: 26106010	2015
Interleukin-10 is a critical regulator of white matter lesion containment following viral induced demyelination. Glia\| PubMed ID: 26132901	2015
Relapses in multiple sclerosis: Relationship to disability. Multiple sclerosis and related disorders\| PubMed ID: 27063617	2016
Is Axonal Degeneration a Key Early Event in Parkinson's Disease? Journal of Parkinson's disease\| PubMed ID: 27497486	2016
Proteolipid protein-deficient myelin promotes axonal mitochondrial dysfunction via altered metabolic coupling. The Journal of cell biology\| PubMed ID: 27872255	2016
Discovery of 1,2,3-Triazole Derivatives for Multimodality PET/CT/Cryoimaging of Myelination in the Central Nervous System. Journal of medicinal chemistry\| PubMed ID: 28107629	2017
GlcNAc6ST-1 regulates sulfation of N-glycans and myelination in the peripheral nervous system. Scientific reports\| PubMed ID: 28186137	2017
BACE1 regulates the proliferation and cellular functions of Schwann cells. Glia\| PubMed ID: 28191691	2017
Integrin-Kindlin3 requirements for microglial motility in vivo are distinct from those for macrophages. JCI insight\| PubMed ID: 28570266	2017
DNA methylation in demyelinated multiple sclerosis hippocampus. Scientific reports\| PubMed ID: 28821749	2017
T1-/T2-weighted ratio differs in demyelinated cortex in multiple sclerosis. Annals of neurology\| PubMed ID: 28833377	2017
Alterations in CA1 hippocampal synapses in a mouse model of fragile X syndrome. Glia\| PubMed ID: 29274095	2018
MR Imaging-based Estimation of Upper Motor Neuron Density in Patients with Amyotrophic Lateral Sclerosis: A Feasibility Study. Radiology\| PubMed ID: 29361242	2018
A histone deacetylase 3-dependent pathway delimits peripheral myelin growth and functional regeneration. Nature medicine\| PubMed ID: 29431744	2018
The role of the thalamus and hippocampus in episodic memory performance in patients with multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England)\| PubMed ID: 29512427	2019
Much, if not all, of the cortical damage in MS can be attributed to the microglial cell - No. Multiple sclerosis (Houndmills, Basingstoke, England)\| PubMed ID: 29754529	2018
Lateral cerebellar nucleus stimulation promotes motor recovery and suppresses neuroinflammation in a fluid percussion injury rodent model. Brain stimulation\| PubMed ID: 30061053	2018
Cortical neuronal densities and cerebral white matter demyelination in multiple sclerosis: a retrospective study. The Lancet. Neurology\| PubMed ID: 30143361	2018
Identifying a new subtype of multiple sclerosis. Neurodegenerative disease management\| PubMed ID: 30215581	2018
pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 31213545	2019
Brain fibrinogen deposition plays a key role in MS pathophysiology - Yes. Multiple sclerosis (Houndmills, Basingstoke, England)\| PubMed ID: 31315512	2019