John W. Mellors

Division of Infectious Diseases, University of Pittsburgh

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 10	2011

Other Publications

Article	Year
Predictive value of immunologic and virologic markers after long or short duration of HIV-1 infection. Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 11917238	2002
Recovery of replication-competent HIV type 1-infected circulating monocytes from individuals receiving antiretroviral therapy. AIDS research and human retroviruses\| PubMed ID: 11958686	2002
Effects of specific zidovudine resistance mutations and substrate structure on nucleotide-dependent primer unblocking by human immunodeficiency virus type 1 reverse transcriptase. Antimicrobial agents and chemotherapy\| PubMed ID: 11959594	2002
Dual vs single protease inhibitor therapy following antiretroviral treatment failure: a randomized trial. JAMA : the journal of the American Medical Association\| PubMed ID: 12095381	2002
Antiretroviral-drug resistance among patients recently infected with HIV. The New England journal of medicine\| PubMed ID: 12167680	2002
Interruption of antiretroviral therapy to augment immune control of chronic HIV-1 infection: risk without reward. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12370421	2002
Virologic and immunologic values allowing safe deferral of antiretroviral therapy. AIDS (London, England)\| PubMed ID: 12461420	2002
Accuracy of the TRUGENE HIV-1 genotyping kit. Journal of clinical microbiology\| PubMed ID: 12682149	2003
Relationship between 3'-azido-3'-deoxythymidine resistance and primer unblocking activity in foscarnet-resistant mutants of human immunodeficiency virus type 1 reverse transcriptase. Journal of virology\| PubMed ID: 12743270	2003
Antiretroviral drug resistance testing in adults infected with human immunodeficiency virus type 1: 2003 recommendations of an International AIDS Society-USA Panel. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 12830416	2003
Questions to and answers from the International AIDS Society-USA Resistance Testing Guidelines Panel. Topics in HIV medicine : a publication of the International AIDS Society, USA\| PubMed ID: 12876334	2003
New real-time reverse transcriptase-initiated PCR assay with single-copy sensitivity for human immunodeficiency virus type 1 RNA in plasma. Journal of clinical microbiology\| PubMed ID: 14532178	2003
Six-year follow-up of HIV-1-infected adults in a clinical trial of antiretroviral therapy with indinavir, zidovudine, and lamivudine. AIDS (London, England)\| PubMed ID: 14571186	2003
A randomized trial of nelfinavir and abacavir in combination with efavirenz and adefovir dipivoxil in HIV-1-infected persons with virological failure receiving indinavir. Antiviral therapy\| PubMed ID: 14760884	2003
Hybrids of [TSAO-T]-[foscarnet]: The first conjugate of foscarnet with a non-nucleoside reverse transcriptase inhibitor through a labile covalent ester bond. Journal of medicinal chemistry\| PubMed ID: 15189038	2004
Genetic correlates of efavirenz hypersusceptibility. AIDS (London, England)\| PubMed ID: 15316338	2004
Prognostic value of plasma HIV RNA among highly active antiretroviral therapy users. AIDS (London, England)\| PubMed ID: 15622318	2004
Multiple, linked human immunodeficiency virus type 1 drug resistance mutations in treatment-experienced patients are missed by standard genotype analysis. Journal of clinical microbiology\| PubMed ID: 15635002	2005
Combining fosamprenavir with lopinavir/ritonavir substantially reduces amprenavir and lopinavir exposure: ACTG protocol A5143 results. AIDS (London, England)\| PubMed ID: 15668539	2005
Mechanism for nucleoside analog-mediated abrogation of HIV-1 replication: balance between RNase H activity and nucleotide excision. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15684061	2005
In vitro activity of structurally diverse nucleoside analogs against human immunodeficiency virus type 1 with the K65R mutation in reverse transcriptase. Antimicrobial agents and chemotherapy\| PubMed ID: 15728915	2005
The 3'-azido group is not the primary determinant of 3'-azido-3'-deoxythymidine (AZT) responsible for the excision phenotype of AZT-resistant HIV-1. The Journal of biological chemistry\| PubMed ID: 15970587	2005
Depletion of latent HIV-1 infection in vivo: a proof-of-concept study. Lancet\| PubMed ID: 16099290	2005
In vitro selection and analysis of human immunodeficiency virus type 1 resistant to derivatives of beta-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine. Antimicrobial agents and chemotherapy\| PubMed ID: 16127074	2005
Sensitive phenotypic detection of minor drug-resistant human immunodeficiency virus type 1 reverse transcriptase variants. Journal of clinical microbiology\| PubMed ID: 16272507	2005
Selection and persistence of non-nucleoside reverse transcriptase inhibitor-resistant HIV-1 in patients starting and stopping non-nucleoside therapy. AIDS (London, England)\| PubMed ID: 16514300	2006
Reverse transcriptase mutations 118I, 208Y, and 215Y cause HIV-1 hypersusceptibility to non-nucleoside reverse transcriptase inhibitors. AIDS (London, England)\| PubMed ID: 16603849	2006
The K65R mutation in human immunodeficiency virus type 1 reverse transcriptase exhibits bidirectional phenotypic antagonism with thymidine analog mutations. Journal of virology\| PubMed ID: 16641288	2006
Potential impact of antiretroviral therapy on HIV-1 transmission and AIDS mortality in resource-limited settings. Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 16652038	2006
Blinded, multicenter comparison of methods to detect a drug-resistant mutant of human immunodeficiency virus type 1 at low frequency. Journal of clinical microbiology\| PubMed ID: 16825395	2006
Antagonism between the HIV-1 reverse-transcriptase mutation K65R and thymidine-analogue mutations at the genomic level. The Journal of infectious diseases\| PubMed ID: 16897664	2006
Regimen simplification to atazanavir-ritonavir alone as maintenance antiretroviral therapy after sustained virologic suppression. JAMA : the journal of the American Medical Association\| PubMed ID: 16905786	2006
A randomized trial of treatment interruption before optimized antiretroviral therapy for persons with drug-resistant HIV: 48-week virologic results of ACTG A5086. The Journal of infectious diseases\| PubMed ID: 17041858	2006
Molecular mechanism by which the K70E mutation in human immunodeficiency virus type 1 reverse transcriptase confers resistance to nucleoside reverse transcriptase inhibitors. Antimicrobial agents and chemotherapy\| PubMed ID: 17088490	2007
The level of persistent HIV viremia does not increase after successful simplification of maintenance therapy to lopinavir/ritonavir alone. AIDS (London, England)\| PubMed ID: 17117019	2006
No cure yet for HIV-1, but therapeutic research presses on. The Journal of infectious diseases\| PubMed ID: 17299705	2007
ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia. PLoS pathogens\| PubMed ID: 17411338	2007
Selection of mutations in the connection and RNase H domains of human immunodeficiency virus type 1 reverse transcriptase that increase resistance to 3'-azido-3'-dideoxythymidine. Journal of virology\| PubMed ID: 17507476	2007
Prognostic value of HIV-1 RNA, CD4 cell count, and CD4 Cell count slope for progression to AIDS and death in untreated HIV-1 infection. JAMA : the journal of the American Medical Association\| PubMed ID: 17551128	2007
Molecular mechanisms of bidirectional antagonism between K65R and thymidine analog mutations in HIV-1 reverse transcriptase. AIDS (London, England)\| PubMed ID: 17589186	2007
Suppression of viremia and evolution of human immunodeficiency virus type 1 drug resistance in a macaque model for antiretroviral therapy. Journal of virology\| PubMed ID: 17855539	2007
Potential impact of antiretroviral chemoprophylaxis on HIV-1 transmission in resource-limited settings. PloS one\| PubMed ID: 17878928	2007
The use of beta-D-2,6-diaminopurine dioxolane with or without mycophenolate mofetil in drug-resistant HIV infection. AIDS (London, England)\| PubMed ID: 17885292	2007
Mechanisms by which the G333D mutation in human immunodeficiency virus type 1 Reverse transcriptase facilitates dual resistance to zidovudine and lamivudine. Antimicrobial agents and chemotherapy\| PubMed ID: 17967907	2008
Madurahydroxylactone derivatives as dual inhibitors of human immunodeficiency virus type 1 integrase and RNase H. Antimicrobial agents and chemotherapy\| PubMed ID: 17967911	2008
Frequent polymorphism at drug resistance sites in HIV-1 protease and reverse transcriptase. AIDS (London, England)\| PubMed ID: 18301062	2008
Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18332425	2008
Randomized study of dual versus single ritonavir-enhanced protease inhibitors for protease inhibitor-experienced patients with HIV. HIV clinical trials\| PubMed ID: 18474494	2008
Class-sparing regimens for initial treatment of HIV-1 infection. The New England journal of medicine\| PubMed ID: 18480202	2008
Antiretroviral drug resistance testing in adult HIV-1 infection: 2008 recommendations of an International AIDS Society-USA panel. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 18549313	2008
YKL-40, a marker of simian immunodeficiency virus encephalitis, modulates the biological activity of basic fibroblast growth factor. The American journal of pathology\| PubMed ID: 18556781	2008
Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control. Immunity\| PubMed ID: 19062316	2008
Mechanism by which a glutamine to leucine substitution at residue 509 in the ribonuclease H domain of HIV-1 reverse transcriptase confers zidovudine resistance. Biochemistry\| PubMed ID: 19067547	2008
Single-dose nevirapine to prevent mother-to-child transmission of HIV type 1: balancing the benefits and risks. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 19133800	2009
Regimen simplification to atazanavir-ritonavir alone as maintenance antiretroviral therapy: final 48-week clinical and virologic outcomes. The Journal of infectious diseases\| PubMed ID: 19191590	2009
Broad advances in understanding HIV resistance to antiretrovirals: report on the XVII International HIV Drug Resistance Workshop. Antiviral therapy\| PubMed ID: 19195337	2008
Simplification strategies to reduce antiretroviral drug exposure: progress and prospects. Antiviral therapy\| PubMed ID: 19320232	2009
Metabolic outcomes in a randomized trial of nucleoside, nonnucleoside and protease inhibitor-sparing regimens for initial HIV treatment. AIDS (London, England)\| PubMed ID: 19417580	2009
Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides. Antimicrobial agents and chemotherapy\| PubMed ID: 19596885	2009
Varied patterns of HIV-1 drug resistance on failing first-line antiretroviral therapy in South Africa. Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 19801944	2010
Antiretroviral drug resistance testing in adult HIV-1 infection: 2008 recommendations of an International AIDS Society-USA panel. Topics in HIV medicine : a publication of the International AIDS Society, USA\| PubMed ID: 19856548	2008
RT-SHIV subpopulation dynamics in infected macaques during anti-HIV therapy. Retrovirology\| PubMed ID: 19889213	2009
Progress in basic and clinical research on HIV resistance: report on the XVIII International HIV Drug Resistance Workshop. Antiviral therapy\| PubMed ID: 19918107	2009
Optimization of allele-specific PCR using patient-specific HIV consensus sequences for primer design. Journal of virological methods\| PubMed ID: 19948190	2010
Synthesis and evaluation of 3'-azido-2',3'-dideoxypurine nucleosides as inhibitors of human immunodeficiency virus. Bioorganic & medicinal chemistry letters\| PubMed ID: 19948402	2010
Low frequency nonnucleoside reverse-transcriptase inhibitor-resistant variants contribute to failure of efavirenz-containing regimens in treatment- experienced patients. The Journal of infectious diseases\| PubMed ID: 20102272	2010
A pilot study to determine the impact on dyslipidemia of adding tenofovir to stable background antiretroviral therapy: ACTG 5206. AIDS (London, England)\| PubMed ID: 20495438	2010
Clonal resistance analyses of HIV type-1 after failure of therapy with didanosine, lamivudine and tenofovir. Antiviral therapy\| PubMed ID: 20516563	2010
Planning for pre-exposure prophylaxis to prevent HIV transmission: challenges and opportunities. Journal of the International AIDS Society\| PubMed ID: 20624303	2010
The effect of raltegravir intensification on low-level residual viremia in HIV-infected patients on antiretroviral therapy: a randomized controlled trial. PLoS medicine\| PubMed ID: 20711481	2010
HIV-1 continues to replicate and evolve in patients with natural control of HIV infection. Journal of virology\| PubMed ID: 20926564	2010
Antiretroviral therapies in women after single-dose nevirapine exposure. The New England journal of medicine\| PubMed ID: 20942666	2010
Genetic diversity of simian immunodeficiency virus encoding HIV-1 reverse transcriptase persists in macaques despite antiretroviral therapy. Journal of virology\| PubMed ID: 21084490	2011
A randomized, placebo-controlled trial of abacavir intensification in HIV-1-infected adults with virologic suppression on a protease inhibitor-containing regimen. HIV clinical trials\| PubMed ID: 21239359	2010
Failure of initial therapy with two nucleosides and efavirenz is not associated with early emergence of mutations in the C-terminus of HIV-1 reverse transcriptase. Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 21350368	2011
HIV and hepatitis virus resistance to antivirals: review of data from the XIX International HIV and Hepatitis Virus Drug Resistance Workshop and curative strategies. Antiviral therapy\| PubMed ID: 21447877	2011
Protease Inhibitor Resistance Is Uncommon in HIV-1 Subtype C Infected Patients on Failing Second-Line Lopinavir/r-Containing Antiretroviral Therapy in South Africa. AIDS research and treatment\| PubMed ID: 21490784	2011
Factors influencing the emergence and spread of HIV drug resistance arising from rollout of antiretroviral pre-exposure prophylaxis (PrEP). PloS one\| PubMed ID: 21525976	2011
Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells. The Journal of biological chemistry\| PubMed ID: 21531716	2011
Role of low-frequency HIV-1 variants in failure of nevirapine-containing antiviral therapy in women previously exposed to single-dose nevirapine. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21576473	2011
The base component of 3'-azido-2',3'-dideoxynucleosides influences resistance mutations selected in HIV-1 reverse transcriptase. Antimicrobial agents and chemotherapy\| PubMed ID: 21646480	2011
Majority of CD4+ T cells from peripheral blood of HIV-1-infected individuals contain only one HIV DNA molecule. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21690402	2011
Synthesis, antiviral activity, cytotoxicity and cellular pharmacology of l-3'-azido-2',3'-dideoxypurine nucleosides. European journal of medicinal chemistry\| PubMed ID: 21700368	2011
Single genome sequencing of HIV-1 gag and protease resistance mutations at virologic failure during the OK04 trial of simplified versus standard maintenance therapy. Antiviral therapy\| PubMed ID: 21817194	2011
Substrate mimicry: HIV-1 reverse transcriptase recognizes 6-modified-3'-azido-2',3'-dideoxyguanosine-5'-triphosphates as adenosine analogs. Nucleic acids research\| PubMed ID: 21914723	2012
Initial viral decay to assess the relative antiretroviral potency of protease inhibitor-sparing, nonnucleoside reverse transcriptase inhibitor-sparing, and nucleoside reverse transcriptase i... AIDS (London, England)\| PubMed ID: 21941167	2011
Short-course raltegravir intensification does not increase 2 long terminal repeat episomal HIV-1 DNA in patients on effective antiretroviral therapy. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 22016501	2012
No Effect of Raltegravir Intensification on Viral Replication Markers in the Blood of HIV-1-Infected Patients Receiving Antiretroviral Therapy. Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 22083073	2012
New Tools for Quantifying HIV-1 Reservoirs: Plasma RNA Single Copy Assays and Beyond. Current HIV/AIDS reports\| PubMed ID: 22215419	2012
Short-course Combivir after single-dose nevirapine reduces but does not eliminate the emergence of nevirapine resistance in women. Antiviral therapy\| PubMed ID: 22293443	2011