Stephen M. Sykes

Stephen M. Sykes

Blood Cell Development and Function Program, Fox Chase Cancer Center

Affiliated withFox Chase Cancer Center

Research Area

Biography

Daniela Di Marcantonio is a Postdoctoral Fellow in Dr. Sykes Lab at the Research Institute of Fox Chase Cancer Center, Philadelphia, US. She received her Bachelor's degree in Biotechnology from the University of Teramo, Italy in 2007 and completed her Master's degree in Biotechnology and Regenerative Medicine from University of Parma, Italy in 2010. There, she joined Dr. Vitale’s lab to study physiological signaling involved in normal muscle stem cell activation and differentiation and received her PhD in Physiopathology in 2015.

In 2015 she moved to Philadelphia to join Dr Sykes’ Lab as a Postdoctoral Fellow. Her work has revealed how protein kinase C epsilon is a positive regulator of mitochondrial Reactive Oxygen Species (ROS) in Acute Myeloid Leukemia (AML), suggesting that increasing oxidative stress in blood malignant cells may be a successful therapeutic strategy in AML. After being awarded a K99 Pathway to Independence award from the National Institute of Health, she is now characterizing and targeting metabolic abnormalities that support AML.

JoVE Journal Publications

ArticleTotal : 1
Year
Flow Cytometric Analysis of Mitochondrial Reactive Oxygen Species in Murine Hematopoietic Stem and Progenitor Cells and MLL-AF9 Driven Leukemia
Publication title
2019

Other Publications

Article
Year
The p53 family and programmed cell death.

Oncogene| PubMed ID: 18955976

2008
2009
2013
Modeling human hematopoietic stem cell biology in the mouse.

Seminars in hematology| PubMed ID: 24216169

2013
2014
2014
mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 25385646

2014
2015
2016
2016
2017
2017
Protein Kinase C Epsilon Is a Key Regulator of Mitochondrial Redox Homeostasis in Acute Myeloid Leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research| PubMed ID: 29127121

2018
2017
2018
2018
2018
2019