Christian L. Lorson

Department of Veterinary Pathobiology, University of Missouri

Research Area

Biography

Christian L. Lorson has not added Biography.
If you are Christian L. Lorson and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 122	2011

Other Publications

Article	Year
A direct interaction between the survival motor neuron protein and p53 and its relationship to spinal muscular atrophy. The Journal of biological chemistry\| PubMed ID: 11704667	2002
SRp30c-dependent stimulation of survival motor neuron (SMN) exon 7 inclusion is facilitated by a direct interaction with hTra2 beta 1. Human molecular genetics\| PubMed ID: 11875052	2002
Minute virus of mice NS1 interacts with the SMN protein, and they colocalize in novel nuclear bodies induced by parvovirus infection. Journal of virology\| PubMed ID: 11907229	2002
Minute virus of mice small nonstructural protein NS2 interacts and colocalizes with the Smn protein. Journal of virology\| PubMed ID: 12021369	2002
Survival motor neuron protein in the nucleolus of mammalian neurons. Brain research\| PubMed ID: 12126878	2002
The Ewing's sarcoma protein interacts with the Tudor domain of the survival motor neuron protein. Brain research. Molecular brain research\| PubMed ID: 14597228	2003
A survival motor neuron:tetanus toxin fragment C fusion protein for the targeted delivery of SMN protein to neurons. Brain research\| PubMed ID: 14644474	2004
Monitoring of recombinant survival motor neuron protein using fiber-optic surface plasmon resonance. The Analyst\| PubMed ID: 15343403	2004
Minute virus of mice small non-structural protein NS2 localizes within, but is not required for the formation of, Smn-associated autonomous parvovirus-associated replication bodies. The Journal of general virology\| PubMed ID: 15784894	2005
A non-sequence-specific requirement for SMN protein activity: the role of aminoglycosides in inducing elevated SMN protein levels. Human molecular genetics\| PubMed ID: 15790598	2005
Stimulating full-length SMN2 expression by delivering bifunctional RNAs via a viral vector. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 16580882	2006
Novel aminoglycosides increase SMN levels in spinal muscular atrophy fibroblasts. Human genetics\| PubMed ID: 16951947	2006
Restoration of SMN function: delivery of a trans-splicing RNA re-directs SMN2 pre-mRNA splicing. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 17551501	2007
Protein phosphatase 1 binds to the RNA recognition motif of several splicing factors and regulates alternative pre-mRNA processing. Human molecular genetics\| PubMed ID: 17913700	2008
Induction of full-length survival motor neuron by polyphenol botanical compounds. Human genetics\| PubMed ID: 17962980	2008
A SMNDelta7 read-through product confers functionality to the SMNDelta7 protein. Neuroscience letters\| PubMed ID: 18601974	2008
Identification and characterization of the porcine (Sus scrofa) survival motor neuron (SMN1) gene: an animal model for therapeutic studies. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 18651653	2008
Identification and characterisation of a nuclear localisation signal in the SMN associated protein, Gemin4. Biochemical and biophysical research communications\| PubMed ID: 18675250	2008
The Wallerian degeneration slow (Wld(s)) gene does not attenuate disease in a mouse model of spinal muscular atrophy. Biochemical and biophysical research communications\| PubMed ID: 18680723	2008
Detection of human survival motor neuron (SMN) protein in mice containing the SMN2 transgene: applicability to preclinical therapy development for spinal muscular atrophy. Journal of neuroscience methods\| PubMed ID: 18771690	2008
Development of a single vector system that enhances trans-splicing of SMN2 transcripts. PloS one\| PubMed ID: 18941511	2008
Delivery of recombinant follistatin lessens disease severity in a mouse model of spinal muscular atrophy. Human molecular genetics\| PubMed ID: 19074460	2009
Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature\| PubMed ID: 19098894	2009
Delivery of bifunctional RNAs that target an intronic repressor and increase SMN levels in an animal model of spinal muscular atrophy. Human molecular genetics\| PubMed ID: 19228773	2009
Delivery of a read-through inducing compound, TC007, lessens the severity of a spinal muscular atrophy animal model. Human molecular genetics\| PubMed ID: 19625298	2009
A negatively acting bifunctional RNA increases survival motor neuron both in vitro and in vivo. Human gene therapy\| PubMed ID: 19848583	2008
Identification of a tripartite import signal in the Ewing Sarcoma protein (EWS). Biochemical and biophysical research communications\| PubMed ID: 19879242	2009
RNA-targeting approaches for neuromuscular diseases. Trends in molecular medicine\| PubMed ID: 19906562	2009
Effect of diet on the survival and phenotype of a mouse model for spinal muscular atrophy. Biochemical and biophysical research communications\| PubMed ID: 19945425	2010
Subcutaneous administration of TC007 reduces disease severity in an animal model of SMA. BMC neuroscience\| PubMed ID: 19948047	2009
Trans-splicing-mediated improvement in a severe mouse model of spinal muscular atrophy. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20053895	2010
Identification of a self-association domain in the Ewing's sarcoma protein: a novel function for arginine-glycine-glycine rich motifs? Journal of biochemistry\| PubMed ID: 20211855	2010
Spinal muscular atrophy: mechanisms and therapeutic strategies. Human molecular genetics\| PubMed ID: 20392710	2010
Cardiac defects contribute to the pathology of spinal muscular atrophy models. Human molecular genetics\| PubMed ID: 20696672	2010
Combination of SMN trans-splicing and a neurotrophic factor increases the life span and body mass in a severe model of spinal muscular atrophy. Human gene therapy\| PubMed ID: 20804424	2011
Therapeutics that directly increase SMN expression to treat spinal muscular atrophy. Drug news & perspectives\| PubMed ID: 21031163	2010
The COPI vesicle complex binds and moves with survival motor neuron within axons. Human molecular genetics\| PubMed ID: 21300694	2011
Disruption of the Survival Motor Neuron (SMN) gene in pigs using ssDNA. Transgenic research\| PubMed ID: 21350916	2011
The spinal muscular atrophy mouse model, SMAÎ”7, displays altered axonal transport without global neurofilament alterations. Acta neuropathologica\| PubMed ID: 21681521	2011
Optimization of SMN Trans-Splicing Through the Analysis of SMN Introns. Journal of molecular neuroscience : MN\| PubMed ID: 21826391	2011
SMN in spinal muscular atrophy and snRNP biogenesis. Wiley interdisciplinary reviews. RNA\| PubMed ID: 21957043	2011
Decreasing Disease Severity in Symptomatic, Smn(-/-);SMN2(+/+), Spinal Muscular Atrophy Mice Following scAAV9-SMN Delivery. Human gene therapy\| PubMed ID: 22029744	2012
Bifunctional RNAs targeting the intronic splicing silencer N1 increase SMN levels and reduce disease severity in an animal model of spinal muscular atrophy. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 22031236	2012
Transgenic inactivation of murine myostatin does not decrease the severity of disease in a model of Spinal Muscular Atrophy. Neuromuscular disorders : NMD\| PubMed ID: 22079083	2011
Direct central nervous system delivery provides enhanced protection following vector mediated gene replacement in a severe model of spinal muscular atrophy. Biochemical and biophysical research communications\| PubMed ID: 22172949	2012
Partial restoration of cardio-vascular defects in a rescued severe model of spinal muscular atrophy. Journal of molecular and cellular cardiology\| PubMed ID: 22285962	2012