Paul R. Langford

Section of Pediatric Infectious Diseases and Allergy, Imperial College London

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 10	2019

Other Publications

Article	Year
Identification and characterization of genomic loci unique to the Brazilian purpuric fever clonal group of H. influenzae biogroup aegyptius: functionality explored using meningococcal homolo... Molecular microbiology\| PubMed ID: 12581362	2003
Identification of Actinobacillus pleuropneumoniae genes important for survival during infection in its natural host. Infection and immunity\| PubMed ID: 12819083	2003
Two TonB systems in Actinobacillus pleuropneumoniae: their roles in iron acquisition and virulence. Infection and immunity\| PubMed ID: 14742511	2004
Harnessing natural transformation in Actinobacillus pleuropneumoniae: a simple method for allelic replacements. FEMS microbiology letters\| PubMed ID: 15063496	2004
The role of the Shigella flexneri yihE gene in LPS synthesis and virulence. Microbiology (Reading, England)\| PubMed ID: 15073317	2004
Functional diversity of three different DsbA proteins from Neisseria meningitidis. Microbiology (Reading, England)\| PubMed ID: 15347757	2004
Expression of heterologous antigens in commensal Neisseria spp.: preservation of conformational epitopes with vaccine potential. Infection and immunity\| PubMed ID: 15501782	2004
Deletion of the ferric uptake regulator Fur impairs the in vitro growth and virulence of Actinobacillus pleuropneumoniae. Infection and immunity\| PubMed ID: 15908404	2005
A novel neisserial shuttle plasmid: a useful new tool for meningococcal research. FEMS microbiology letters\| PubMed ID: 16112819	2005
Biomarker discovery in infectious diseases using SELDI. Future microbiology\| PubMed ID: 17661674	2007
The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b). Journal of bacteriology\| PubMed ID: 18065534	2008
Analysis of the Actinobacillus pleuropneumoniae ArcA regulon identifies fumarate reductase as a determinant of virulence. Infection and immunity\| PubMed ID: 18378638	2008
A Neisseria meningitidis NMB1966 mutant is impaired for invasion of respiratory epithelial cells, survival in human blood and for virulence in vivo. Medical microbiology and immunology\| PubMed ID: 19050914	2009
Pasteurellaceae ComE1 proteins combine the properties of fibronectin adhesins and DNA binding competence proteins. PloS one\| PubMed ID: 19098981	2008
Meningococcal biofilm growth on an abiotic surface - a model for epithelial colonization? Microbiology (Reading, England)\| PubMed ID: 19383679	2009
Natural competence in strains of Actinobacillus pleuropneumoniae. FEMS microbiology letters\| PubMed ID: 19659732	2009
New plasmid tools for genetic analysis of Actinobacillus pleuropneumoniae and other pasteurellaceae. Applied and environmental microbiology\| PubMed ID: 19666733	2009
Proteomic analysis of endometrium from fertile and infertile patients suggests a role for apolipoprotein A-I in embryo implantation failure and endometriosis. Molecular human reproduction\| PubMed ID: 20008415	2010
Regulation of pga operon expression and biofilm formation in Actinobacillus pleuropneumoniae by sigmaE and H-NS. Journal of bacteriology\| PubMed ID: 20207760	2010
Population-based analysis of Actinobacillus pleuropneumoniae ApxIVA for use as a DIVA antigen. Vaccine\| PubMed ID: 20483193	2010
Meningitis: latest developments. Future microbiology\| PubMed ID: 21797686	2011
Genome wide expression profiling reveals suppression of host defence responses during colonisation by Neisseria meningitides but not N. lactamica. PloS one\| PubMed ID: 22028815	2011
Lineage-specific virulence determinants of Haemophilus influenzae biogroup aegyptius. Emerging infectious diseases\| PubMed ID: 22377449	2012
Transcriptional profiling of serogroup B Neisseria meningitidis growing in human blood: an approach to vaccine antigen discovery. PloS one\| PubMed ID: 22745818	2012
Gene content and diversity of the loci encoding biosynthesis of capsular polysaccharides of the 15 serovar reference strains of Haemophilus parasuis. Journal of bacteriology\| PubMed ID: 23873912	2013
Development of a self-replicating plasmid system for Mycoplasma hyopneumoniae. Veterinary research\| PubMed ID: 23895236	2013
Impairment of IFN-gamma response to synthetic peptides of Mycobacterium tuberculosis in a 7-day whole blood assay. PloS one\| PubMed ID: 23951140	2013
Transcriptional profiling of Neisseria meningitidis interacting with human epithelial cells in a long-term in vitro colonization model. Infection and immunity\| PubMed ID: 23980104	2013
Identification of proteins of Propionibacterium acnes for use as vaccine candidates to prevent infection by the pig pathogen Actinobacillus pleuropneumoniae. Vaccine\| PubMed ID: 24051157	2013
Detection of tuberculosis in HIV-infected and -uninfected African adults using whole blood RNA expression signatures: a case-control study. PLoS medicine\| PubMed ID: 24167453	2013
Transposon mutagenesis in Mycoplasma hyopneumoniae using a novel mariner-based system for generating random mutations. Veterinary research\| PubMed ID: 24359443	2013
Multiplex PCR assay for unequivocal differentiation of Actinobacillus pleuropneumoniae serovars 1 to 3, 5 to 8, 10, and 12. Journal of clinical microbiology\| PubMed ID: 24759717	2014
Diagnosis of childhood tuberculosis and host RNA expression in Africa. The New England journal of medicine\| PubMed ID: 24785206	2014
Dysbiosis anticipating necrotizing enterocolitis in very premature infants. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 25344536	2015
The generation of successive unmarked mutations and chromosomal insertion of heterologous genes in Actinobacillus pleuropneumoniae using natural transformation. PloS one\| PubMed ID: 25409017	2014
Galleria mellonella is an effective model to study Actinobacillus pleuropneumoniae infection. Microbiology (Reading, England)\| PubMed ID: 25414045	2015
The use of genome wide association methods to investigate pathogenicity, population structure and serovar in Haemophilus parasuis. BMC genomics\| PubMed ID: 25539682	2014
Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis. Nature communications\| PubMed ID: 25824154	2015
Identification of dfrA14 in two distinct plasmids conferring trimethoprim resistance in Actinobacillus pleuropneumoniae. The Journal of antimicrobial chemotherapy\| PubMed ID: 25957382	2015
Characterisation of a mobilisable plasmid conferring florfenicol and chloramphenicol resistance in Actinobacillus pleuropneumoniae. Veterinary microbiology\| PubMed ID: 26049592	2015
Late-Onset Bloodstream Infection and Perturbed Maturation of the Gastrointestinal Microbiota in Premature Infants. PloS one\| PubMed ID: 26167683	2015
PHiD-CV induces anti-Protein D antibodies but does not augment pulmonary clearance of nontypeable Haemophilus influenzae in mice. Vaccine\| PubMed ID: 26212006	2015
Development of a Multiplex PCR Assay for Rapid Molecular Serotyping of Haemophilus parasuis. Journal of clinical microbiology\| PubMed ID: 26424843	2015
Structural, Functional, and Immunogenic Insights on Cu,Zn Superoxide Dismutase Pathogenic Virulence Factors from Neisseria meningitidis and Brucella abortus. Journal of bacteriology\| PubMed ID: 26459556	2015
Role of (p)ppGpp in Viability and Biofilm Formation of Actinobacillus pleuropneumoniae S8. PloS one\| PubMed ID: 26509499	2015
Whole genome investigation of a divergent clade of the pathogen Streptococcus suis. Frontiers in microbiology\| PubMed ID: 26583006	2015
Complete Genome Sequence of MIDG2331, a Genetically Tractable Serovar 8 Clinical Isolate of Actinobacillus pleuropneumoniae. Genome announcements\| PubMed ID: 26823596	2016
Unnatural amino acid analogues of membrane-active helical peptides with anti-mycobacterial activity and improved stability. The Journal of antimicrobial chemotherapy\| PubMed ID: 27118774	2016
ICEApl1, an Integrative Conjugative Element Related to ICEHin1056, Identified in the Pig Pathogen Actinobacillus pleuropneumoniae. Frontiers in microbiology\| PubMed ID: 27379024	2016
A computational strategy for the search of regulatory small RNAs in Actinobacillus pleuropneumoniae. RNA (New York, N.Y.)\| PubMed ID: 27402897	2016
A Unique Capsule Locus in the Newly Designated Actinobacillus pleuropneumoniae Serovar 16 and Development of a Diagnostic PCR Assay. Journal of clinical microbiology\| PubMed ID: 28053219	2017
The N-linking glycosylation system from Actinobacillus pleuropneumoniae is required for adhesion and has potential use in glycoengineering. Open biology\| PubMed ID: 28077594	2017
Inactivation of , Encoding a Sel1-Like Repeat (SLR) Protein, in Neisseria meningitidis Is Associated with Differential Expression of Genes Belonging to the Fur Regulon and Reduced Intraepith... Infection and immunity\| PubMed ID: 28264906	2017
Whole Genome Sequencing for Surveillance of Antimicrobial Resistance in . Frontiers in microbiology\| PubMed ID: 28321207	2017
Disruption of drug-resistant biofilms using de novo designed short α-helical antimicrobial peptides with idealized facial amphiphilicity. Acta biomaterialia\| PubMed ID: 28457962	2017
Identification of novel Haemophilus parasuis serovar 5 vaccine candidates using an immunoproteomic approach. Journal of proteomics\| PubMed ID: 28528009	2017
p518, a small floR plasmid from a South American isolate of Actinobacillus pleuropneumoniae. Veterinary microbiology\| PubMed ID: 28532791	2017
Haemophilus parasuis cytolethal distending toxin induces cell cycle arrest and p53-dependent apoptosis. PloS one\| PubMed ID: 28545143	2017
"Pathotyping" Multiplex PCR Assay for Haemophilus parasuis: a Tool for Prediction of Virulence. Journal of clinical microbiology\| PubMed ID: 28615466	2017
B cell cross-epitope of Propionibacterium acnes and Actinobacillus pleuropneumonia selected by phage display library can efficiently protect from Actinobacillus pleuropneumonia infection. Veterinary microbiology\| PubMed ID: 28622855	2017
Patterns of antimicrobial resistance in Streptococcus suis isolates from pigs with or without streptococcal disease in England between 2009 and 2014. Veterinary microbiology\| PubMed ID: 28757010	2017
Characterization of the Actinobacillus pleuropneumoniae SXT-related integrative and conjugative element ICEApl2 and analysis of the encoded FloR protein: hydrophobic residues in transmembran... The Journal of antimicrobial chemotherapy\| PubMed ID: 29029160	2018
Regarding flagellar expression in clinical isolates of non-typeable Haemophilus influenzae. Journal of medical microbiology\| PubMed ID: 29087280	2017
Use of Proteins Identified through a Functional Genomic Screen To Develop a Protein Subunit Vaccine That Provides Significant Protection against Virulent Streptococcus suis in Pigs. Infection and immunity\| PubMed ID: 29203546	2018
Proposal of serovars 17 and 18 of Actinobacillus pleuropneumoniae based on serological and genotypic analysis. Veterinary microbiology\| PubMed ID: 29615241	2018
Comparative sequence analysis of the capsular polysaccharide loci of Actinobacillus pleuropneumoniae serovars 1-18, and development of two multiplex PCRs for comprehensive capsule typing. Veterinary microbiology\| PubMed ID: 29885806	2018
Transcriptomic analysis of porcine PBMCs in response to Actinobacillus pleuropneumoniae reveals the dynamic changes of differentially expressed genes related to immuno-inflammatory responses... Antonie van Leeuwenhoek\| PubMed ID: 30008077	2018
Cross-Reactive Bactericidal Antimeningococcal Antibodies Can Be Isolated From Convalescing Invasive Meningococcal Disease Patients Using Reverse Vaccinology 2.0. Frontiers in immunology\| PubMed ID: 30061891	2018
Galleria mellonella - a novel infection model for the Mycobacterium tuberculosis complex. Virulence\| PubMed ID: 30067135	2018
Bacterial Vaccine Antigen Discovery in the Reverse Vaccinology 2.0 Era: Progress and Challenges. Frontiers in immunology\| PubMed ID: 30349542	2018
Evidence of Illegitimate Recombination Between Two Plasmids Resulting in a Novel Multi-Resistance Replicon, pM3362MDR, in . Frontiers in microbiology\| PubMed ID: 30405558	2018
Pathotyping the Zoonotic Pathogen Streptococcus suis: Novel Genetic Markers To Differentiate Invasive Disease-Associated Isolates from Non-Disease-Associated Isolates from England and Wales. Journal of clinical microbiology\| PubMed ID: 30944194	2019