Manfred S. Weiss

Macromolecular Crystallography (HZB-MX), Helmholtz-Zentrum Berlin

Affiliated withHelmholtz-Zentrum Berlin

Research Area

Biochemistry

Biography

1989 - 1992 Ph.D. student at the Albert-Ludwigs-University Freiburg i. Br.

1992 - 1996 Postdoc at University of California at Los Angeles

1996 - 2001 Senior Research Assistant at the Institute of Molecular Biotechnology in Jena

2001 - 2009 Team Leader at the EMBL Hamburg Outstation

2009-present Helmholtz-Zentrum Berlin

JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 18	2021
Publication title Cited by 4	2019
Publication title Cited by 1	2021

Other Publications

Article	Year
Citations in supplementary material. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 21139193	2010
Crystallization and preliminary X-ray diffraction analysis of the wild-type haloalkane dehalogenase DhaA and its variant DhaA13 complexed with different ligands. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 21301099	2011
Publishing structural genomics results continued: the SSGCID special issue. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 22102017	2011
Review panel for Acta Crystallographica Section F. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 22102222	2011
Facilities for macromolecular crystallography at the Helmholtz-Zentrum Berlin. Journal of synchrotron radiation\| PubMed ID: 22514183	2012
Structure determination by multiple-wavelength anomalous dispersion (MAD) at the Pr LIII edge. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 22869138	2012
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of AHP2, a signal transmitter protein from Arabidopsis thaliana. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 23385758	2013
Big changes are ahead--a new format for crystallization communications in Acta Cryst. F. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 24316820	2013
Structural Sampling of Glycan Interaction Profiles Reveals Mucosal Receptors for Fimbrial Adhesins of Enterotoxigenic Escherichia coli. Biology\| PubMed ID: 24833052	2013
Protein crystalline frameworks with controllable interpenetration directed by dual supramolecular interactions. Nature communications\| PubMed ID: 25144207	2014
The times they are a-changin' - news from Acta Crystallographica Section F. Acta crystallographica. Section F, Structural biology communications\| PubMed ID: 25484202	2014
Glutamate 270 plays an essential role in K(+)-activation and domain closure of Thermus thermophilus isopropylmalate dehydrogenase. FEBS letters\| PubMed ID: 25497013	2015
Against the odds? De novo structure determination of a pilin with two cysteine residues by sulfur SAD. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 25945575	2015
Macromolecular crystallography and what it can contribute to antiparasite drug discovery. Acta crystallographica. Section F, Structural biology communications\| PubMed ID: 25945700	2015
Native SAD is maturing. IUCrJ\| PubMed ID: 26175902	2015
Combining dehydration, construct optimization and improved data collection to solve the crystal structure of a CRM1-RanGTP-SPN1-Nup214 quaternary nuclear export complex. Acta crystallographica. Section F, Structural biology communications\| PubMed ID: 26625290	2015
Dual Role of the Active Site Residues of Thermus thermophilus 3-Isopropylmalate Dehydrogenase: Chemical Catalysis and Domain Closure. Biochemistry\| PubMed ID: 26731489	2016
Six Biophysical Screening Methods Miss a Large Proportion of Crystallographically Discovered Fragment Hits: A Case Study. ACS chemical biology\| PubMed ID: 27028906	2016
Structures of endothiapepsin-fragment complexes from crystallographic fragment screening using a novel, diverse and affordable 96-compound fragment library. Acta crystallographica. Section F, Structural biology communications\| PubMed ID: 27139825	2016
Structure-based Epitope Mapping of Mycobacterium tuberculosis Secretary Antigen MTC28. The Journal of biological chemistry\| PubMed ID: 27189947	2016
High-Throughput Crystallography: Reliable and Efficient Identification of Fragment Hits. Structure (London, England : 1993)\| PubMed ID: 27452405	2016
Experimental Active-Site Mapping by Fragments: Hot Spots Remote from the Catalytic Center of Endothiapepsin. Journal of medicinal chemistry\| PubMed ID: 27463859	2016
A critical examination of the recently reported crystal structures of the human SMN protein. Human molecular genetics\| PubMed ID: 27577872	2016
Active Site Mapping of an Aspartic Protease by Multiple Fragment Crystal Structures: Versatile Warheads To Address a Catalytic Dyad. Journal of medicinal chemistry\| PubMed ID: 27726357	2016
Long-Wavelength X-Ray Diffraction and Its Applications in Macromolecular Crystallography. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 28573583	2017
Substrate specificity and reaction mechanism of human prolidase. The FEBS journal\| PubMed ID: 28677335	2017
Crystal structures of the disease-causing D444V mutant and the relevant wild type human dihydrolipoamide dehydrogenase. Free radical biology & medicine\| PubMed ID: 29908278	2018
Structural basis for prolidase deficiency disease mechanisms. The FEBS journal\| PubMed ID: 30066404	2018
Elucidating the Formation and Transformation Mechanisms of the Switchable Metal-Organic Framework ELM-11 by Powder and Single-Crystal EPR Study. Inorganic chemistry\| PubMed ID: 30207461	2018
MXCuBE2: the dawn of MXCuBE Collaboration. Journal of synchrotron radiation\| PubMed ID: 30855248	2019
Structure of the plastic-degrading Ideonella sakaiensis MHETase bound to a substrate. Nature communications\| PubMed ID: 30979881	2019
Findable Accessible Interoperable Re-usable (FAIR) diffraction data are coming to protein crystallography. Acta crystallographica. Section F, Structural biology communications\| PubMed ID: 31045560	2019
Findable Accessible Interoperable Re-usable (FAIR) diffraction data are coming to protein crystallography. Acta crystallographica. Section D, Structural biology\| PubMed ID: 31063147	2019
Findable Accessible Interoperable Re-usable (FAIR) diffraction data are coming to protein crystallography. IUCrJ\| PubMed ID: 31098014	2019
Findable Accessible Interoperable Re-usable (FAIR) diffraction data are coming to protein crystallography. Journal of applied crystallography\| PubMed ID: 31236090	2019
Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants. Human molecular genetics\| PubMed ID: 31334547	2019
Structure-Based Screening of Tetrazolylhydrazide Inhibitors versus KDM4 Histone Demethylases. ChemMedChem\| PubMed ID: 31475772	2019
In Situ Imine-Based Linker Formation for the Synthesis of Zirconium MOFs: A Route to CO Capture Materials and Ethylene Oligomerization Catalysts. Inorganic chemistry\| PubMed ID: 31820946	2020
Regioselectivity of hyoscyamine 6β-hydroxylase-catalysed hydroxylation as revealed by high-resolution structural information and QM/MM calculations. Dalton transactions (Cambridge, England : 2003)\| PubMed ID: 32182320	2020
F2X-Universal and F2X-Entry: Structurally Diverse Compound Libraries for Crystallographic Fragment Screening. Structure (London, England : 1993)\| PubMed ID: 32413289	2020
Co-expression with chaperones can affect protein 3D structure as exemplified by loss-of-function variants of human prolidase. FEBS letters\| PubMed ID: 32598484	2020
The susceptibility of disulfide bonds towards radiation damage may be explained by S⋯O interactions. IUCrJ\| PubMed ID: 32939274	2020
Prolidase - A protein with many faces. Biochimie\| PubMed ID: 33045291	2020
Insulin polymorphism induced by two polyphenols: new crystal forms and advances in macromolecular powder diffraction. Acta crystallographica. Section D, Structural biology\| PubMed ID: 33135678	2020
The hypothetical periplasmic protein PA1624 from Pseudomonas aeruginosa folds into a unique two-domain structure. Acta crystallographica. Section F, Structural biology communications\| PubMed ID: 33263573	2020
X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease. Science (New York, N.Y.)\| PubMed ID: 33811162	2021
Facilitated crystal handling using a simple device for evaporation reduction in microtiter plates. Journal of applied crystallography\| PubMed ID: 33833659	2021
Structural analysis of new compound heterozygous variants in PEPD gene identified in a patient with Prolidase Deficiency diagnosed by exome sequencing. Genetics and molecular biology\| PubMed ID: 33877262	2021
FragMAXapp: crystallographic fragment-screening data-analysis and project-management system. Acta crystallographica. Section D, Structural biology\| PubMed ID: 34076593	2021
Engineering micromechanics of soft porous crystals for negative gas adsorption. Chemical science\| PubMed ID: 34094213	2020
Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives. Purinergic signalling\| PubMed ID: 34403084	2021
Frag4Lead: growing crystallographic fragment hits by catalog using fragment-guided template docking. Acta crystallographica. Section D, Structural biology\| PubMed ID: 34473087	2021
Enhanced Properties of a Benzimidazole Benzylpyrazole Lysine Demethylase Inhibitor: Mechanism-of-Action, Binding Site Analysis, and Activity in Cellular Models of Prostate Cancer. Journal of medicinal chemistry\| PubMed ID: 34555281	2021
Unique features of the bifunctional GH30 from Thermothelomyces thermophila revealed by structural and mutational studies. Carbohydrate polymers\| PubMed ID: 34560965	2021
DYW domain structures imply an unusual regulation principle in plant organellar RNA editing catalysis. Nature catalysis\| PubMed ID: 34712911	2021