quantification-three-dna-lesions-mass-spectrometry-assessment-their

Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter

DNA adducts and oxidized DNA bases are examples of DNA lesions that are useful biomarkers for the toxicity assessment of substances that are ...

Universidade De São Paulo (USP)

Universidade de São Paulo

To investigate the effect of Botulinum toxin A (BoNTA) on skin flap viability in healthy, tobacco-exposed and diabetic rats.

Botulinum toxin type A on cutaneous flap viability in diabetic and tobacco-exposed rats.

To evaluate pulmonary function in the first and third trimesters of pregnancy and analyze the influence of parity and smoking on spirometry parameters.

Longitudinal study of lung function in pregnant women: Influence of parity and smoking.

The Metropolitan Area of São Paulo has a unique composition of atmospheric pollutants, and positive correlations between exposure and the risk of diseases and mortality have been observed. Here we assessed the effects of ambient fine particulate matter (PM) on genotoxic and global DNA methylation and hydroxymethylation changes, as well as the activities of antioxidant enzymes, in tissues of AJ mice exposed whole body to ambient air enriched in PM, which was concentrated in a chamber near an avenue of intense traffic in São Paulo City, Brazil.

Article	Year
Botulinum toxin type A on cutaneous flap viability in diabetic and tobacco-exposed rats. Acta cirurgica brasileira\| PubMed ID: 26465109	2015
Longitudinal study of lung function in pregnant women: Influence of parity and smoking. Clinics (Sao Paulo, Brazil)\| PubMed ID: 29160421	2017
Genotoxic and epigenotoxic effects in mice exposed to concentrated ambient fine particulate matter (PM) from São Paulo city, Brazil. Particle and fibre toxicology\| PubMed ID: 30340610	2018

Miriam Lemos

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