Valter D. Longo

Andrus Gerontology Center, University of Southern California, Los Angeles

Affiliated withUniversity of Southern California, Los Angeles

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 13	2011

Other Publications

Article	Year
Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microglia. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 11978825	2002
Genetics of aging and diseases: from rare mutations and model systems to disease prevention. Archives of neurology\| PubMed ID: 12433254	2002
SOD2 functions downstream of Sch9 to extend longevity in yeast. Genetics\| PubMed ID: 12586694	2003
Evolutionary medicine: from dwarf model systems to healthy centenarians? Science (New York, N.Y.)\| PubMed ID: 12610293	2003
The Ras and Sch9 pathways regulate stress resistance and longevity. Experimental gerontology\| PubMed ID: 12855292	2003
The chronological life span of Saccharomyces cerevisiae. Aging cell\| PubMed ID: 12882320	2003
Oxygen? No thanks, I'm on a diet. Science of aging knowledge environment : SAGE KE\| PubMed ID: 14602992	2002
Biodemographic trajectories of age-specific reproliferation from stationary phase in the yeast Saccharomyces cerevisiae seem multiphasic. Mechanisms of ageing and development\| PubMed ID: 14659594	2003
Search for methuselah genes heats up. Science of aging knowledge environment : SAGE KE\| PubMed ID: 14960761	2004
Superoxide inhibits 4Fe-4S cluster enzymes involved in amino acid biosynthesis. Cross-compartment protection by CuZn-superoxide dismutase. The Journal of biological chemistry\| PubMed ID: 15166213	2004
Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae. The Journal of cell biology\| PubMed ID: 15452146	2004
Ras: the other pro-aging pathway. Science of aging knowledge environment : SAGE KE\| PubMed ID: 15456908	2004
Analysis of gene expression profile in yeast aging chronologically. Mechanisms of ageing and development\| PubMed ID: 15610757	2005
Sir2 blocks extreme life-span extension. Cell\| PubMed ID: 16286010	2005
Programmed and altruistic ageing. Nature reviews. Genetics\| PubMed ID: 16304601	2005
Aging as a mitochondria-mediated atavistic program: can aging be switched off? Annals of the New York Academy of Sciences\| PubMed ID: 16399892	2005
Sirtuins in aging and age-related disease. Cell\| PubMed ID: 16873059	2006
Inference of transcription modification in long-live yeast strains from their expression profiles. BMC genomics\| PubMed ID: 17617911	2007
The chronological life span of Saccharomyces cerevisiae. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 17634576	2007
Significant and systematic expression differentiation in long-lived yeast strains. PloS one\| PubMed ID: 17971858	2007
Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system. The Journal of cell biology\| PubMed ID: 18195102	2008
Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9. PLoS genetics\| PubMed ID: 18225956	2008
Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18378900	2008
Chronological aging-induced apoptosis in yeast. Biochimica et biophysica acta\| PubMed ID: 18445486	2008
SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell metabolism\| PubMed ID: 18590691	2008
Linking sirtuins, IGF-I signaling, and starvation. Experimental gerontology\| PubMed ID: 18638538	2009
The chronological life span of Saccharomyces cerevisiae to study mitochondrial dysfunction and disease. Methods (San Diego, Calif.)\| PubMed ID: 18930829	2008
Turning anti-ageing genes against cancer. Nature reviews. Molecular cell biology\| PubMed ID: 18946478	2008
Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension. PLoS genetics\| PubMed ID: 19424415	2009
Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polzeta-dependent mechanism. The Journal of cell biology\| PubMed ID: 19687253	2009
Comparative analyses of time-course gene expression profiles of the long-lived sch9Delta mutant. Nucleic acids research\| PubMed ID: 19880387	2010
Calorie restriction and cancer prevention: metabolic and molecular mechanisms. Trends in pharmacological sciences\| PubMed ID: 20097433	2010
Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain. TheScientificWorldJournal\| PubMed ID: 20098959	2010
Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index. Cancer research\| PubMed ID: 20145127	2010
Fasting and cancer treatment in humans: A case series report. Aging\| PubMed ID: 20157582	2009
Extending healthy life span--from yeast to humans. Science (New York, N.Y.)\| PubMed ID: 20395504	2010
Cell resilience in species life spans: a link to inflammation? Aging cell\| PubMed ID: 20415721	2010
Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation. PLoS genetics\| PubMed ID: 20657825	2010
SIRT1 is essential for normal cognitive function and synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20660252	2010
E. coli hypoxia-inducible factor ArcA mediates lifespan extension in a lipoic acid synthase mutant by suppressing acetyl-CoA synthetase. Biological chemistry\| PubMed ID: 20707605	2010
Genome-wide screen identifies Escherichia coli TCA-cycle-related mutants with extended chronological lifespan dependent on acetate metabolism and the hypoxia-inducible transcription factor A... Aging cell\| PubMed ID: 20707865	2010
Endosomal protein sorting and autophagy genes contribute to the regulation of yeast life span. Autophagy\| PubMed ID: 20953148	2010
Linking Klotho, Nrf2, MAP kinases and aging. Aging\| PubMed ID: 21076180	2010
Fasting and differential chemotherapy protection in patients. Cell cycle (Georgetown, Tex.)\| PubMed ID: 21088487	2010
Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Science translational medicine\| PubMed ID: 21325617	2011
Metabolic alterations in yeast lacking copper-zinc superoxide dismutase. Free radical biology & medicine\| PubMed ID: 21397007	2011
Lifespan extension and paraquat resistance in a ubiquinone-deficient Escherichia coli mutant depend on transcription factors ArcA and TdcA. Aging\| PubMed ID: 21464517	2011
Conserved role of Ras-GEFs in promoting aging: from yeast to mice. Aging\| PubMed ID: 21732566	2011
Chronological Aging in Saccharomyces cerevisiae. Sub-cellular biochemistry\| PubMed ID: 22094419	2012
Intermittent supplementation with rapamycin as a dietary restriction mimetic. Aging\| PubMed ID: 22147496	2011
Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy. Science translational medicine\| PubMed ID: 22323820	2012