Gail V.W. Johnson

Departments of Anesthesiology, University of Rochester

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 29	2011

Other Publications

Article	Year
Does tissue transglutaminase play a role in Huntington's disease? Neurochemistry international\| PubMed ID: 11738471	2002
Mutant huntingtin aggregates do not sensitize cells to apoptotic stressors. FEBS letters\| PubMed ID: 11943195	2002
Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12048243	2002
Cdk5 phosphorylates p53 and regulates its activity. Journal of neurochemistry\| PubMed ID: 12064478	2002
Tissue transglutaminase differentially modulates apoptosis in a stimuli-dependent manner. Journal of neurochemistry\| PubMed ID: 12065637	2002
Identification of the N-terminal functional domains of Cdk5 by molecular truncation and computer modeling. Proteins\| PubMed ID: 12112670	2002
Glycogen synthase kinase 3beta phosphorylates tau at both primed and unprimed sites. Differential impact on microtubule binding. The Journal of biological chemistry\| PubMed ID: 12409305	2003
Axin negatively affects tau phosphorylation by glycogen synthase kinase 3beta. Journal of neurochemistry\| PubMed ID: 12421363	2002
Tau, where are we now? Journal of Alzheimer's disease : JAD\| PubMed ID: 12446970	2002
Cystamine inhibits caspase activity. Implications for the treatment of polyglutamine disorders. The Journal of biological chemistry\| PubMed ID: 12458211	2003
Transient osmotic stress facilitates mutant huntingtin aggregation. Neuroreport\| PubMed ID: 12499864	2002
Tissue transglutaminase directly regulates adenylyl cyclase resulting in enhanced cAMP-response element-binding protein (CREB) activation. The Journal of biological chemistry\| PubMed ID: 12743114	2003
The p38 MAP kinase signaling pathway in Alzheimer's disease. Experimental neurology\| PubMed ID: 14552867	2003
Mutant (R406W) human tau is hyperphosphorylated and does not efficiently bind microtubules in a neuronal cortical cell model. The Journal of biological chemistry\| PubMed ID: 14660557	2004
Intracellular localization and activity state of tissue transglutaminase differentially impacts cell death. The Journal of biological chemistry\| PubMed ID: 14670969	2004
Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules. Journal of neurochemistry\| PubMed ID: 14690523	2004
Striatal cells from mutant huntingtin knock-in mice are selectively vulnerable to mitochondrial complex II inhibitor-induced cell death through a non-apoptotic pathway. Human molecular genetics\| PubMed ID: 14962977	2004
Immunoblot analysis reveals that isopeptide antibodies do not specifically recognize the epsilon-(gamma-glutamyl)lysine bonds formed by transglutaminase activity. Journal of neuroscience methods\| PubMed ID: 15003381	2004
Cyclin-dependent kinase-5 in neurodegeneration. Journal of neurochemistry\| PubMed ID: 15009631	2004
Validity of mouse models for the study of tissue transglutaminase in neurodegenerative diseases. Molecular and cellular neurosciences\| PubMed ID: 15033177	2004
Effects of cyclin-dependent kinase-5 activity on apoptosis and tau phosphorylation in immortalized mouse brain cortical cells. Journal of neuroscience research\| PubMed ID: 15048935	2004
The glamour and gloom of glycogen synthase kinase-3. Trends in biochemical sciences\| PubMed ID: 15102436	2004
Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release. Human molecular genetics\| PubMed ID: 15163634	2004
Tissue transglutaminase is not involved in the aggregate formation of stably expressed alpha-synuclein in SH-SY5Y human neuroblastoma cells. Archives of pharmacal research\| PubMed ID: 15460447	2004
Glycogen synthase kinase 3 beta induces caspase-cleaved tau aggregation in situ. The Journal of biological chemistry\| PubMed ID: 15494420	2004
FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation. The Journal of biological chemistry\| PubMed ID: 15522877	2005
Tau phosphorylation in neuronal cell function and dysfunction. Journal of cell science\| PubMed ID: 15537830	2004
Developmental regulation of tissue transglutaminase in the mouse forebrain. Journal of neurochemistry\| PubMed ID: 15584913	2004
Tissue transglutaminase contributes to disease progression in the R6/2 Huntington's disease mouse model via aggregate-independent mechanisms. Journal of neurochemistry\| PubMed ID: 15606898	2005
Tau phosphorylation: physiological and pathological consequences. Biochimica et biophysica acta\| PubMed ID: 15615646	2005
Transglutaminases in neurodegenerative disorders. Progress in experimental tumor research\| PubMed ID: 15746534	2005
Role of the intracellular domains of LRP5 and LRP6 in activating the Wnt canonical pathway. Journal of cellular biochemistry\| PubMed ID: 15778991	2005
Verification of somatic CAG repeat expansion by pre-PCR fractionation. Journal of neuroscience methods\| PubMed ID: 15848234	2005
The protective effects of cystamine in the R6/2 Huntington's disease mouse involve mechanisms other than the inhibition of tissue transglutaminase. Neurobiology of aging\| PubMed ID: 15896882	2006
14-3-3Zeta does not increase GSK3beta-mediated tau phosphorylation in cell culture models. Neuroscience letters\| PubMed ID: 15963640	2005
Mitochondrial respiration and ATP production are significantly impaired in striatal cells expressing mutant huntingtin. The Journal of biological chemistry\| PubMed ID: 15983033	2005
Increased glutathione levels in cortical and striatal mitochondria of the R6/2 Huntington's disease mouse model. Neuroscience letters\| PubMed ID: 15993538	2005
Cystamine treatment is neuroprotective in the YAC128 mouse model of Huntington disease. Journal of neurochemistry\| PubMed ID: 16181425	2005
The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity. The Journal of biological chemistry\| PubMed ID: 16365045	2006
Tissue transglutaminase overexpression in the brain potentiates calcium-induced hippocampal damage. Journal of neurochemistry\| PubMed ID: 16539654	2006
Site-specific phosphorylation and caspase cleavage differentially impact tau-microtubule interactions and tau aggregation. The Journal of biological chemistry\| PubMed ID: 16687396	2006
Tau phosphorylation and proteolysis: insights and perspectives. Journal of Alzheimer's disease : JAD\| PubMed ID: 16914862	2006
Mutant huntingtin expression induces mitochondrial calcium handling defects in clonal striatal cells: functional consequences. The Journal of biological chemistry\| PubMed ID: 16973623	2006
The role of tau phosphorylation and cleavage in neuronal cell death. Frontiers in bioscience : a journal and virtual library\| PubMed ID: 17127334	2007
Transglutaminase 2 in neurodegenerative disorders. Frontiers in bioscience : a journal and virtual library\| PubMed ID: 17127346	2007
Tau is hyperphosphorylated at multiple sites in mouse brain in vivo after streptozotocin-induced insulin deficiency. Diabetes\| PubMed ID: 17130475	2006
The role of tau phosphorylation in the pathogenesis of Alzheimer's disease. Current Alzheimer research\| PubMed ID: 17168644	2006
Regulated proteolytic processing of LRP6 results in release of its intracellular domain. Journal of neurochemistry\| PubMed ID: 17326769	2007
Mitochondrial-targeted active Akt protects SH-SY5Y neuroblastoma cells from staurosporine-induced apoptotic cell death. Journal of cellular biochemistry\| PubMed ID: 17340627	2007
Type 2 transglutaminase differentially modulates striatal cell death in the presence of wild type or mutant huntingtin. Journal of neurochemistry\| PubMed ID: 17403029	2007
Ubiquitin-proteasome system alterations in a striatal cell model of Huntington's disease. Journal of neuroscience research\| PubMed ID: 17455294	2007
Activation of glycogen synthase kinase 3beta promotes the intermolecular association of tau. The use of fluorescence resonance energy transfer microscopy. The Journal of biological chemistry\| PubMed ID: 17565981	2007
Split GFP complementation assay: a novel approach to quantitatively measure aggregation of tau in situ: effects of GSK3beta activation and caspase 3 cleavage. Journal of neurochemistry\| PubMed ID: 17908237	2007
Transglutaminase 2 protects against ischemic insult, interacts with HIF1beta, and attenuates HIF1 signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 18375543	2008
New application of beta-galactosidase complementation to monitor tau self-association. Journal of neurochemistry\| PubMed ID: 18498442	2008
Histone deacetylase 6 interacts with the microtubule-associated protein tau. Journal of neurochemistry\| PubMed ID: 18636984	2008
Rosiglitazone treatment prevents mitochondrial dysfunction in mutant huntingtin-expressing cells: possible role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in the pathoge... The Journal of biological chemistry\| PubMed ID: 18640979	2008
The last tangle of tau. Journal of Alzheimer's disease : JAD\| PubMed ID: 18688096	2008
Increased expression of Bim contributes to the potentiation of serum deprivation-induced apoptotic cell death in Huntington's disease knock-in striatal cell line. Neurological research\| PubMed ID: 18691453	2009
Immortalized cortical neurons expressing caspase-cleaved tau are sensitized to endoplasmic reticulum stress induced cell death. Brain research\| PubMed ID: 18718455	2008
Caspase-cleaved tau expression induces mitochondrial dysfunction in immortalized cortical neurons: implications for the pathogenesis of Alzheimer disease. The Journal of biological chemistry\| PubMed ID: 19389700	2009
Intracellular localization and conformational state of transglutaminase 2: implications for cell death. PloS one\| PubMed ID: 19568436	2009
Role of mitochondrial dysfunction in the pathogenesis of Huntington's disease. Brain research bulletin\| PubMed ID: 19622387	2009
Phosphorylation of PPP(S/T)P motif of the free LRP6 intracellular domain is not required to activate the Wnt/beta-catenin pathway and attenuate GSK3beta activity. Journal of cellular biochemistry\| PubMed ID: 19711366	2009
A caspase cleaved form of tau is preferentially degraded through the autophagy pathway. The Journal of biological chemistry\| PubMed ID: 20466727	2010
The interrelationship between mitochondrial dysfunction and transcriptional dysregulation in Huntington disease. Journal of bioenergetics and biomembranes\| PubMed ID: 20556492	2010
Differential modulation of TCF/LEF-1 activity by the soluble LRP6-ICD. PloS one\| PubMed ID: 20676368	2010
The role of tau kinases in Alzheimer's disease. Current opinion in drug discovery & development\| PubMed ID: 20812151	2010
AES/GRG5: more than just a dominant-negative TLE/GRG family member. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 20925119	2010
Split GFP complementation assay for quantitative measurement of tau aggregation in situ. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 20967587	2011
Cytosolic guanine nucledotide binding deficient form of transglutaminase 2 (R580a) potentiates cell death in oxygen glucose deprivation. PloS one\| PubMed ID: 21304968	2011
The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics. Journal of cellular and molecular medicine\| PubMed ID: 21348938	2011
Truncated tau and AÎ² cooperatively impair mitochondria in primary neurons. Neurobiology of aging\| PubMed ID: 21450370	2012
Transglutaminase 2 and its role in pulmonary fibrosis. American journal of respiratory and critical care medicine\| PubMed ID: 21700912	2011
Decreases in valosin-containing protein result in increased levels of tau phosphorylated at Ser262/356. FEBS letters\| PubMed ID: 21983102	2011
Transglutaminase 2: A molecular Swiss army knife. Biochimica et biophysica acta\| PubMed ID: 22015769	2012
Complete transglutaminase 2 ablation results in reduced stroke volumes and astrocytes that exhibit increased survival in response to ischemia. Neurobiology of disease\| PubMed ID: 22198379	2012
Metabolic State Determines Sensitivity to Cellular Stress in Huntington Disease: Normalization by Activation of PPARÎ³. PloS one\| PubMed ID: 22276192	2012