inverse-probability-treatment-weighting-propensity-score-using

Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index

When randomized controlled trials are not feasible, retrospective studies using big data provide an efficient and cost-effective alternative, though they ...

Medical College of Wisconsin

Overall opioid prescribing rates have decreased since 2012, but opioid-involved deaths have not. This study describes the regional and overall trends of opioid-related emergency department visits (EDVs) and hospitalizations of commercially insured patients on chronic opioids and those on concurrent opioids and benzodiazepines.

Opioid-related Emergency Department Visits and Hospitalizations Among Commercially Insured Individuals, 2009-2015.

The effect of advanced practice provider (APP) involvement in oncology care on cancer-specific outcomes is unknown. We examined the association between team-based APP-physician care during chemotherapy and chemotherapy-related adverse events (AEs) among women with breast cancer.

Investigating the Association Between Advanced Practice Providers and Chemotherapy-Related Adverse Events in Women With Breast Cancer: A Nested Case-Control Study.

Compared with traditional risk factors, coronary artery calcium (CAC) scores improve prognostic accuracy for atherosclerotic cardiovascular disease (ASCVD) outcomes. However, the relative impact of statins on ASCVD outcomes stratified by CAC scores is unknown.

Impact of Statins on Cardiovascular Outcomes Following Coronary Artery Calcium Scoring.

We extend an interrupted time series study design to identify heterogenous treatment effects using group-based trajectory models (GBTMs) to identify groups before a new policy and then examine if the effects of the policy has consistent impacts across groups using propensity score weighting to balance individuals within trajectory groups who are and are not exposed to the policy change. We explore this by examining how adherence to endocrine therapy (ET) for women with breast cancer was impacted by reducing copayments for medications by the introduction of generic ETs among women who do not receive a subsidy (the "treatment" group) to those that do receive a subsidy and are not exposed to any changes in copayments (the "control" group).

Using Group-based Trajectory Models and Propensity Score Weighting to Detect Heterogeneous Treatment Effects: The Case Study of Generic Hormonal Therapy for Women With Breast Cancer.

Despite the well-documented association of medication refill synchronization with medication adherence, little is known about how best to measure synchronization at pharmacy visits or about its relationship to number of medications.

Factors Influencing Prescription Drug Synchronization: The Complex Role of Number of Medications.

There are known gender differences in the impacts infertility has on quality of life and well-being. Less is known about how infertile couples spend time on fertility-related tasks and associations with quality of life. The purpose of this study is to evaluate whether time spent on tasks related to family-building decision-making (including research, reflection, discussions with partner, discussions with others, and logistics) were associated with fertility-specific quality of life or anxiety among new patients.

Too much time? Time use and fertility-specific quality of life among men and women seeking specialty care for infertility.

One-third to one-half of patients prescribed adjuvant endocrine therapy are nonadherent during the recommended 5-year endocrine therapy course. This study investigated whether poor pharmacy synchronization of medication fills (requiring refills on different days) acts as a barrier to adherence.

The association of pharmacy fill synchronization with breast cancer endocrine therapy adherence.

Guidelines recommend using caution in co-prescribing opioids with benzodiazepines yet, in practice, the extent of concurrent prescribing is poorly understood. Notably, no population-based studies have investigated concurrent prescribing among patients with cancer. We conducted a retrospective cohort study using SEER-Medicare data (2012-2016) for women diagnosed with breast cancer. We used modified Poisson regression to examine predictors of any concurrent prescriptions in the year post-diagnosis, and Poisson regression to examine predictors of the number of overlapping days. We found that 13.0% of the 19,267 women in our sample had concurrent prescriptions. Women who underwent more extensive treatment and those with prior use of opioids or benzodiazepines were at increased risk for concurrent prescriptions (aRR prior benzodiazepine use vs. no prior use:15.05, 95% CI:13.19-17.19). Among women with concurrent prescriptions, overlap was most pronounced among low-income, rural and Hispanic women (aIRR Hispanic vs. Non-Hispanic White:1.25, 95% CI:1.20-1.30). Our results highlight opportunities to reduce patients' unnecessary exposure to this combination.

Concurrent Opioid and Benzodiazepine Prescriptions among Older Women Diagnosed with Breast Cancer.

To examine morphine milligram equivalent (MME) trends, use of concurrent opioids and benzodiazepines, and opioid-related emergency department (ED) visits or hospitalizations in a national cohort of patients on chronic opioid therapy.

Opioid Dose and Benzodiazepine Use Among Commercially Insured Individuals on Chronic Opioid Therapy.

Patients with cancer-related pain are underrepresented in the opioid literature despite high opioid exposure and numerous risk factors for adverse opioid outcomes, including unnecessary persistent opioid use. The objective of this study was to determine the extent, historical trends, and predictors of new-onset persistent opioid use among older adult women after active breast cancer treatment.

Article	Year
Opioid-related Emergency Department Visits and Hospitalizations Among Commercially Insured Individuals, 2009-2015. The Clinical journal of pain\| PubMed ID: 30113319	2018
Investigating the Association Between Advanced Practice Providers and Chemotherapy-Related Adverse Events in Women With Breast Cancer: A Nested Case-Control Study. Journal of oncology practice\| PubMed ID: 30303759	2018
Impact of Statins on Cardiovascular Outcomes Following Coronary Artery Calcium Scoring. Journal of the American College of Cardiology\| PubMed ID: 30409567	2018
Using Group-based Trajectory Models and Propensity Score Weighting to Detect Heterogeneous Treatment Effects: The Case Study of Generic Hormonal Therapy for Women With Breast Cancer. Medical care\| PubMed ID: 30489546	2019
Factors Influencing Prescription Drug Synchronization: The Complex Role of Number of Medications. Journal of managed care & specialty pharmacy\| PubMed ID: 31134859	2019
Too much time? Time use and fertility-specific quality of life among men and women seeking specialty care for infertility. BMC psychology\| PubMed ID: 31288855	2019
The association of pharmacy fill synchronization with breast cancer endocrine therapy adherence. Cancer\| PubMed ID: 31373689	2019
Concurrent Opioid and Benzodiazepine Prescriptions among Older Women Diagnosed with Breast Cancer. Journal of the National Cancer Institute\| PubMed ID: 31605134	2019
Opioid Dose and Benzodiazepine Use Among Commercially Insured Individuals on Chronic Opioid Therapy. Pain medicine (Malden, Mass.)\| PubMed ID: 31804688	2019
New-onset persistent opioid use following breast cancer treatment in older adult women. Cancer\| PubMed ID: 31846054	2019
Association of Use of Online Symptom Checkers With Patients' Plans for Seeking Care. JAMA network open\| PubMed ID: 31880791	2019

Nicole Fergestrom

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