John P. A. Ioannidis

Departments of Medicine, Stanford University School of Humanities and Sciences

Affiliated withStanford University School of Humanities and Sciences

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 100	2019

Other Publications

Article	Year
Reproducibility in science: improving the standard for basic and preclinical research. Circulation research\| PubMed ID: 25552691	2015
Type 2 diabetes and cancer: umbrella review of meta-analyses of observational studies. BMJ (Clinical research ed.)\| PubMed ID: 25555821	2015
Improving validation practices in "omics" research. Science (New York, N.Y.)\| PubMed ID: 22144616	2011
Randomized trial of personal genomics for preventive cardiology: design and challenges. Circulation. Cardiovascular genetics\| PubMed ID: 22715281	2012
Concordance of sleep and pain outcomes of diverse interventions: an umbrella review. PloS one\| PubMed ID: 22815856	2012
Extrapolating from animals to humans. Science translational medicine\| PubMed ID: 22972841	2012
Neglected tropical diseases: survey and geometry of randomised evidence. BMJ (Clinical research ed.)\| PubMed ID: 23089149	2012
Knowledge integration in cancer: current landscape and future prospects. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 23093546	2013
A nutrient-wide association study on blood pressure. Circulation\| PubMed ID: 23093587	2012
Opportunities and challenges for selected emerging technologies in cancer epidemiology: mitochondrial, epigenomic, metabolomic, and telomerase profiling. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 23242141	2013
Narrow band imaging to differentiate neoplastic and non-neoplastic colorectal polyps in real time: a meta-analysis of diagnostic operating characteristics. Gut\| PubMed ID: 23300139	2013
Replication and predictive value of SNPs associated with melanoma and pigmentation traits in a Southern European case-control study. PloS one\| PubMed ID: 23393597	2013
Transforming epidemiology for 21st century medicine and public health. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 23462917	2013
This I believe in genetics: discovery can be a nuisance, replication is science, implementation matters. Frontiers in genetics\| PubMed ID: 23505393	2013
Trends in citations to books on epidemiological and statistical methods in the biomedical literature. PloS one\| PubMed ID: 23667447	2013
The power of meta-analysis in genome-wide association studies. Annual review of genomics and human genetics\| PubMed ID: 23724904	2013
The geometric increase in meta-analyses from China in the genomic era. PloS one\| PubMed ID: 23776510	2013
How many contemporary medical practices are worse than doing nothing or doing less? Mayo Clinic proceedings\| PubMed ID: 23871231	2013
Overlapping meta-analyses on the same topic: survey of published studies. BMJ (Clinical research ed.)\| PubMed ID: 23873947	2013
Evaluation of excess significance bias in animal studies of neurological diseases. PLoS biology\| PubMed ID: 23874156	2013
Appropriate vs clinically useful diagnostic tests. JAMA internal medicine\| PubMed ID: 23877418	2013
Potential reporting bias in fMRI studies of the brain. PloS one\| PubMed ID: 23936149	2013
Autonomic denervation added to pulmonary vein isolation for paroxysmal atrial fibrillation: a randomized clinical trial. Journal of the American College of Cardiology\| PubMed ID: 23973694	2013
Collaborative cancer epidemiology in the 21st century: the model of cancer consortia. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 24045926	2013
Geometry of the randomized evidence for treatments of pulmonary hypertension. Cardiovascular therapeutics\| PubMed ID: 24112824	2013
Endgame: engaging the tobacco industry in its own elimination. European journal of clinical investigation\| PubMed ID: 24117211	2013
Concordance of effects of medical interventions on hospital admission and readmission rates with effects on mortality. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne\| PubMed ID: 24144601	2013
Prevention and management of noncommunicable disease: the IOC Consensus Statement, Lausanne 2013. Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine\| PubMed ID: 24169298	2013
More than a billion people taking statins?: Potential implications of the new cardiovascular guidelines. JAMA\| PubMed ID: 24296612	2014
Scientific reporting is suboptimal for aspects that characterize genetic risk prediction studies: a review of published articles based on the Genetic RIsk Prediction Studies statement. Journal of clinical epidemiology\| PubMed ID: 24411311	2014
Improving the drug development process: more not less randomized trials. JAMA\| PubMed ID: 24449311	2014
Mapping the expanded often inappropriate use of the Framingham Risk Score in the medical literature. Journal of clinical epidemiology\| PubMed ID: 24513280	2014
Publication and other reporting biases in cognitive sciences: detection, prevalence, and prevention. Trends in cognitive sciences\| PubMed ID: 24656991	2014
Effects of interventions on survival in acute respiratory distress syndrome: an umbrella review of 159 published randomized trials and 29 meta-analyses. Intensive care medicine\| PubMed ID: 24667919	2014
Diagnostic tests often fail to lead to changes in patient outcomes. Journal of clinical epidemiology\| PubMed ID: 24679598	2014
Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials. BMJ (Clinical research ed.)\| PubMed ID: 24690624	2014
Errors (my very own) and the fearful uncertainty of numbers. European journal of clinical investigation\| PubMed ID: 24785138	2014
Studying the elusive environment in large scale. JAMA\| PubMed ID: 24893084	2014
Metformin does not affect cancer risk: a cohort study in the U.K. Clinical Practice Research Datalink analyzed like an intention-to-treat trial. Diabetes care\| PubMed ID: 24898303	2014
Assessing value in biomedical research: the PQRST of appraisal and reward. JAMA\| PubMed ID: 24911291	2014
Placing epidemiological results in the context of multiplicity and typical correlations of exposures. Journal of epidemiology and community health\| PubMed ID: 24923805	2014
How to read a systematic review and meta-analysis and apply the results to patient care: users' guides to the medical literature. JAMA\| PubMed ID: 25005654	2014
Modeling and research on research. Clinical chemistry\| PubMed ID: 25037936	2014
Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance. Journal of medical genetics\| PubMed ID: 25057126	2014
Simple, standardized incorporation of genetic risk into non-genetic risk prediction tools for complex traits: coronary heart disease as an example. Frontiers in genetics\| PubMed ID: 25136350	2014
How to make more published research true. PLoS medicine\| PubMed ID: 25334033	2014
An overview of recommendations and translational milestones for genomic tests in cancer. Genetics in medicine : official journal of the American College of Medical Genetics\| PubMed ID: 25341115	2015
The diagnostic accuracy of the Patient Health Questionnaire-2 (PHQ-2), Patient Health Questionnaire-8 (PHQ-8), and Patient Health Questionnaire-9 (PHQ-9) for detecting major depression: prot... Systematic reviews\| PubMed ID: 25348422	2014
A Web-based database of genetic association studies in cutaneous melanoma enhanced with network-driven data exploration tools. Database : the journal of biological databases and curation\| PubMed ID: 25380778	2014
Application of credibility ceilings probes the robustness of meta-analyses of biomarkers and cancer risk. Journal of clinical epidemiology\| PubMed ID: 25433443	2015
External validation of new risk prediction models is infrequent and reveals worse prognostic discrimination. Journal of clinical epidemiology\| PubMed ID: 25441703	2015
A generalized view of self-citation: direct, co-author, collaborative, and coercive induced self-citation. Journal of psychosomatic research\| PubMed ID: 25466321	2015
Handling the fragile vase of scientific practices. Addiction (Abingdon, England)\| PubMed ID: 25515825	2015
Does screening for disease save lives in asymptomatic adults? Systematic review of meta-analyses and randomized trials. International journal of epidemiology\| PubMed ID: 25596211	2015
Environmental risk factors and multiple sclerosis: an umbrella review of systematic reviews and meta-analyses. The Lancet. Neurology\| PubMed ID: 25662901	2015
Authors' reply to editorial linked to their umbrella review of meta-analyses of observational studies on type 2 diabetes and cancer. BMJ (Clinical research ed.)\| PubMed ID: 25673332	2015
Response to letter by Forike et al.: more rigorous, not less, external validation is needed. Journal of clinical epidemiology\| PubMed ID: 25724895	2016
Call to improve transparency of trials of non-regulated interventions. BMJ (Clinical research ed.)\| PubMed ID: 25820265	2015
Small studies are more heterogeneous than large ones: a meta-meta-analysis. Journal of clinical epidemiology\| PubMed ID: 25959635	2015
Reply to letter by Ferrante di Ruffano et al.: Patient outcomes in randomized comparisons of diagnostic tests are still the ultimate judge. Journal of clinical epidemiology\| PubMed ID: 26130596	2016
Why Science Is Not Necessarily Self-Correcting. Perspectives on psychological science : a journal of the Association for Psychological Science\| PubMed ID: 26168125	2012
Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modelling study. The Lancet. Neurology\| PubMed ID: 26271532	2015
Assessment of vibration of effects due to model specification can demonstrate the instability of observational associations. Journal of clinical epidemiology\| PubMed ID: 26279400	2015
Registration practices for observational studies on ClinicalTrials.gov indicated low adherence. Journal of clinical epidemiology\| PubMed ID: 26386325	2016
Meta-analyses with industry involvement are massively published and report no caveats for antidepressants. Journal of clinical epidemiology\| PubMed ID: 26399904	2016
Field-wide meta-analyses of observational associations can map selective availability of risk factors and the impact of model specifications. Journal of clinical epidemiology\| PubMed ID: 26415577	2016
Diagnostic accuracy of the Edinburgh Postnatal Depression Scale (EPDS) for detecting major depression in pregnant and postnatal women: protocol for a systematic review and individual patient... BMJ open\| PubMed ID: 26486977	2015
Noninferiority is almost certain with lenient noninferiority margins. Journal of clinical epidemiology\| PubMed ID: 26607237	2016
Generic versus brand-name drugs used in cardiovascular diseases. European journal of epidemiology\| PubMed ID: 26620809	2016
Exposure-wide epidemiology: revisiting Bradford Hill. Statistics in medicine\| PubMed ID: 26646432	2016
Reproducible Research Practices and Transparency across the Biomedical Literature. PLoS biology\| PubMed ID: 26726926	2016
Environmental risk factors and Parkinson's disease: An umbrella review of meta-analyses. Parkinsonism & related disorders\| PubMed ID: 26739246	2016
Response to Therapy in Antiretroviral Therapy-Naive Patients With Isolated Nonnucleoside Reverse Transcriptase Inhibitor-Associated Transmitted Drug Resistance. Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 26855248	2016
Agreement of treatment effects for mortality from routinely collected data and subsequent randomized trials: meta-epidemiological survey. BMJ (Clinical research ed.)\| PubMed ID: 26858277	2016
Routinely collected data and comparative effectiveness evidence: promises and limitations. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne\| PubMed ID: 26883316	2016
Commentary: Salt and the assault of opinion on evidence. International journal of epidemiology\| PubMed ID: 26888871	2016
Evidence-based medicine has been hijacked: a report to David Sackett. Journal of clinical epidemiology\| PubMed ID: 26934549	2016
Prediction of Melanoma Risk in a Southern European Population Based on a Weighted Genetic Risk Score. The Journal of investigative dermatology\| PubMed ID: 27015455	2016
Biases in obesity research: Identify, correct, endorse, or abandon effort? Obesity (Silver Spring, Md.)\| PubMed ID: 27028277	2016
High quality of the evidence for medical and other health-related interventions was uncommon in Cochrane systematic reviews. Journal of clinical epidemiology\| PubMed ID: 27032875	2016
Comparative rates of harms in randomized trials from more developed versus less developed countries may be different. Journal of clinical epidemiology\| PubMed ID: 27063207	2016
Diagnostic accuracy of the Depression subscale of the Hospital Anxiety and Depression Scale (HADS-D) for detecting major depression: protocol for a systematic review and individual patient d... BMJ open\| PubMed ID: 27075844	2016
Long noncoding RNAs as novel predictors of survival in human cancer: a systematic review and meta-analysis. Molecular cancer\| PubMed ID: 27352941	2016
Multiple Citation Indicators and Their Composite across Scientific Disciplines. PLoS biology\| PubMed ID: 27367269	2016
Randomized trials are frequently fragmented in multiple secondary publications. Journal of clinical epidemiology\| PubMed ID: 27387965	2016
Registered Randomized Trials Comparing Generic and Brand-Name Drugs: A Survey. Mayo Clinic proceedings\| PubMed ID: 27402583	2016
Plea for routinely presenting prediction intervals in meta-analysis. BMJ open\| PubMed ID: 27406637	2016
Citation Metrics: A Primer on How (Not) to Normalize. PLoS biology\| PubMed ID: 27599158	2016
Systematic evaluation of the associations between environmental risk factors and dementia: An umbrella review of systematic reviews and meta-analyses. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 27599208	2017
The Mass Production of Redundant, Misleading, and Conflicted Systematic Reviews and Meta-analyses. The Milbank quarterly\| PubMed ID: 27620683	2016
Insomnia From Drug Treatments: Evidence From Meta-analyses of Randomized Trials and Concordance With Prescribing Information. Mayo Clinic proceedings\| PubMed ID: 27842706	2017
Authors' reply to Pérol and colleagues. BMJ (Clinical research ed.)\| PubMed ID: 27986652	2016
Biomedical Journals and Preprint Services: Friends or Foes? Clinical chemistry\| PubMed ID: 27998906	2017
DIETFITS study (diet intervention examining the factors interacting with treatment success) - Study design and methods. Contemporary clinical trials\| PubMed ID: 28027950	2017
Drivers of poor medical care. Lancet (London, England)\| PubMed ID: 28077235	2017
Does evidence-based hearsay determine the use of medical treatments? Social science & medicine (1982)\| PubMed ID: 28190627	2017
Evaluation of Evidence of Statistical Support and Corroboration of Subgroup Claims in Randomized Clinical Trials. JAMA internal medicine\| PubMed ID: 28192563	2017
Waste, Leaks, and Failures in the Biomarker Pipeline. Clinical chemistry\| PubMed ID: 28270433	2017
The Reproducibility Wars: Successful, Unsuccessful, Uninterpretable, Exact, Conceptual, Triangulated, Contested Replication. Clinical chemistry\| PubMed ID: 28298413	2017
Meta-assessment of bias in science. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28320937	2017
Ethics and Epistemology in Big Data Research. Journal of bioethical inquiry\| PubMed ID: 28321561	2017
Genome-wide association screens for Achilles tendon and ACL tears and tendinopathy. PloS one\| PubMed ID: 28358823	2017
A meta-analysis of individual participant data constructed to align with prior expert views: comments on Bhupathiraju et al. Journal of clinical epidemiology\| PubMed ID: 28411080	2017
A meta-analysis but not a systematic review: an evaluation of the Global BMI Mortality Collaboration. Journal of clinical epidemiology\| PubMed ID: 28435099	2017
Hijacked evidence-based medicine: stay the course and throw the pirates overboard. Journal of clinical epidemiology\| PubMed ID: 28532611	2017
Nature, Nurture, and Cancer Risks: Genetic and Nutritional Contributions to Cancer. Annual review of nutrition\| PubMed ID: 28826375	2017
Impact of a Genetic Risk Score for Coronary Artery Disease on Reducing Cardiovascular Risk: A Pilot Randomized Controlled Study. Frontiers in cardiovascular medicine\| PubMed ID: 28856136	2017
How to survive the medical misinformation mess. European journal of clinical investigation\| PubMed ID: 28881000	2017
Interpretation of epidemiologic studies very often lacked adequate consideration of confounding. Journal of clinical epidemiology\| PubMed ID: 28943377	2018
Two genetic loci associated with ankle injury. PloS one\| PubMed ID: 28957384	2017
Off-label treatments were not consistently better or worse than approved drug treatments in randomized trials. Journal of clinical epidemiology\| PubMed ID: 29146289	2018
Physical activity and cancer: an umbrella review of the literature including 22 major anatomical sites and 770 000 cancer cases. British journal of sports medicine\| PubMed ID: 29146752	2018
Poor performance of clinical prediction models: the harm of commonly applied methods. Journal of clinical epidemiology\| PubMed ID: 29174118	2018
Genome-wide association study identifies a locus associated with rotator cuff injury. PloS one\| PubMed ID: 29228018	2017
Dynamics of co-authorship and productivity across different fields of scientific research. PloS one\| PubMed ID: 29320509	2018
Routinely collected data for randomized trials: promises, barriers, and implications. Trials\| PubMed ID: 29325575	2018
What causes psychosis? An umbrella review of risk and protective factors. World psychiatry : official journal of the World Psychiatric Association (WPA)\| PubMed ID: 29352556	2018
Improving the integrity of published science: An expanded taxonomy of retractions and corrections. European journal of clinical investigation\| PubMed ID: 29369337	2018
Larger effect sizes in nonrandomized studies are associated with higher rates of EMA licensing approval. Journal of clinical epidemiology\| PubMed ID: 29432860	2018
Data sharing and reanalysis of randomized controlled trials in leading biomedical journals with a full data sharing policy: survey of studies published in and . BMJ (Clinical research ed.)\| PubMed ID: 29440066	2018
Effect of Low-Fat vs Low-Carbohydrate Diet on 12-Month Weight Loss in Overweight Adults and the Association With Genotype Pattern or Insulin Secretion: The DIETFITS Randomized Clinical Trial... JAMA\| PubMed ID: 29466592	2018
Meta-research: Why research on research matters. PLoS biology\| PubMed ID: 29534060	2018
Two Genetic Variants Associated with Plantar Fascial Disorders. International journal of sports medicine\| PubMed ID: 29534260	2018
The Obesity Paradox: A Misleading Term That Should Be Abandoned. Obesity (Silver Spring, Md.)\| PubMed ID: 29570246	2018
Meta-analyses in environmental and occupational health. Occupational and environmental medicine\| PubMed ID: 29574405	2018
Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic? BMC medicine\| PubMed ID: 29615035	2018
Antidepressants might work for people with major depression: where do we go from here? The lancet. Psychiatry\| PubMed ID: 29628364	2018
Radiofrequency Ablation Versus Antiarrhythmic Drug Therapy for Atrial Fibrillation: Meta-Analysis of Quality of Life, Morbidity, and Mortality. JACC. Clinical electrophysiology\| PubMed ID: 29766867	2016
Randomized controlled trials: Often flawed, mostly useless, clearly indispensable: A commentary on Deaton and Cartwright. Social science & medicine (1982)\| PubMed ID: 29776687	2018
Lack of evidence to favor specific preventive interventions in psychosis: a network meta-analysis. World psychiatry : official journal of the World Psychiatric Association (WPA)\| PubMed ID: 29856551	2018
Prevalence and outcomes of incidental imaging findings: umbrella review. BMJ (Clinical research ed.)\| PubMed ID: 29914908	2018
Environmental risk factors and nonpharmacological and nonsurgical interventions for obesity: An umbrella review of meta-analyses of cohort studies and randomized controlled trials. European journal of clinical investigation\| PubMed ID: 29923186	2018
Industry-funded versus non-profit-funded critical care research: a meta-epidemiological overview. Intensive care medicine\| PubMed ID: 30151688	2018
The Comparative Effectiveness of Innovative Treatments for Cancer (CEIT-Cancer) project: Rationale and design of the database and the collection of evidence available at approval of novel dr... Trials\| PubMed ID: 30231912	2018
Massive citations to misleading methods and research tools: Matthew effect, quotation error and citation copying. European journal of epidemiology\| PubMed ID: 30291530	2018
Extremely large outlier treatment effects may be a footprint of bias in trials from less developed countries: randomized trials of gabapentinoids. Journal of clinical epidemiology\| PubMed ID: 30366063	2019
Correction to: Industry-funded versus non-profit-funded critical care research: a meta-epidemiological overview. Intensive care medicine\| PubMed ID: 30406805	2018
Marginal structural models and other analyses allow multiple estimates of treatment effects in randomized clinical trials: Meta-epidemiological analysis. Journal of clinical epidemiology\| PubMed ID: 30423375	2019
Diagnostic accuracy of the Geriatric Depression Scale-30, Geriatric Depression Scale-15, Geriatric Depression Scale-5 and Geriatric Depression Scale-4 for detecting major depression: protoco... BMJ open\| PubMed ID: 30518594	2018
Cochrane crisis: Secrecy, intolerance and evidence-based values. European journal of clinical investigation\| PubMed ID: 30520025	2019
Gene-environment interactions and colorectal cancer risk: An umbrella review of systematic reviews and meta-analyses of observational studies. International journal of cancer\| PubMed ID: 30536881	2019
A Comprehensive Analysis of Protocols for Deriving Dopaminergic Neurons from Human Pluripotent Stem Cells. Stem cells translational medicine\| PubMed ID: 30537442	2019
Time to abandon early detection cancer screening. European journal of clinical investigation\| PubMed ID: 30565674	2019
New clinical trial designs in the era of precision medicine: An overview of definitions, strengths, weaknesses, and current use in oncology. Cancer treatment reviews\| PubMed ID: 30572165	2019
Flawed methods and inappropriate conclusions for health policy on overweight and obesity: the Global BMI Mortality Collaboration meta-analysis. Journal of cachexia, sarcopenia and muscle\| PubMed ID: 30656860	2019
Toward unrestricted use of public genomic data. Science (New York, N.Y.)\| PubMed ID: 30679363	2019
Unreformed nutritional epidemiology: a lamp post in the dark forest. European journal of epidemiology\| PubMed ID: 30746584	2019
Are all mental disorders related to all other medical diseases and vice versa? Journal of psychosomatic research\| PubMed ID: 30782358	2019
Exploration, Inference, and Prediction in Neuroscience and Biomedicine. Trends in neurosciences\| PubMed ID: 30808574	2019
Author Reply to: The name of the game: Is preventive screening "cancer screening?" European journal of clinical investigation\| PubMed ID: 30829396	2019
How to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation. Nature biomedical engineering\| PubMed ID: 30931172	2018
Reproducible pharmacokinetics. Journal of pharmacokinetics and pharmacodynamics\| PubMed ID: 31004315	2019
Single pivotal trials with few corroborating characteristics were used for FDA approval of cancer therapies. Journal of clinical epidemiology\| PubMed ID: 31158450	2019
Interventions to improve cardiopulmonary resuscitation: a review of meta-analyses and future agenda. Critical care (London, England)\| PubMed ID: 31174581	2019
A user's guide to inflated and manipulated impact factors. European journal of clinical investigation\| PubMed ID: 31206647	2019
An empirical assessment of research practices across 163 clinical trials of tumor-bearing companion dogs. Scientific reports\| PubMed ID: 31417164	2019
Toward a paradigm shift in treatment and research of mental disorders. Psychological medicine\| PubMed ID: 31474241	2019
US Food and Drug Administration Approvals of Drugs and Devices Based on Nonrandomized Clinical Trials: A Systematic Review and Meta-analysis. JAMA network open\| PubMed ID: 31509209	2019
Evidence Relating Health Care Provider Burnout and Quality of Care: A Systematic Review and Meta-analysis. Annals of internal medicine\| PubMed ID: 31590181	2019
Age-treatment subgroup analyses in Cochrane intervention reviews: a meta-epidemiological study. BMC medicine\| PubMed ID: 31639007	2019
Most recommended medical interventions reach P<0.005 for their primary outcomes in meta-analyses. International journal of epidemiology\| PubMed ID: 31764988	2019