Jonathan W. Astin

Department of Molecular Medicine and Pathology, University of Auckland

Research Area

Biography

My research focuses on understanding how vascular development is regulated. My research utilises the zebrafish model of vertebrate development which has transgenic tools that allow us to visualise the developing lymphatic and blood vessels. We couple high-resolution in vivo imaging with both forward and reverse genetics, to uncover how blood and lymphatic vessels form in the developing embryo.

JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 3	2019
Publication title Cited by 2	2020

Other Publications

Article	Year
DMXAA (Vadimezan, ASA404) is a multi-kinase inhibitor targeting VEGFR2 in particular. Clinical science (London, England : 1979)\| PubMed ID: 22142330	2012
lyve1 expression reveals novel lymphatic vessels and new mechanisms for lymphatic vessel development in zebrafish. Development (Cambridge, England)\| PubMed ID: 22627281	2012
Immunoresponsive gene 1 augments bactericidal activity of macrophage-lineage cells by regulating β-oxidation-dependent mitochondrial ROS production. Cell metabolism\| PubMed ID: 23931757	2013
Pkd1 regulates lymphatic vascular morphogenesis during development. Cell reports\| PubMed ID: 24767999	2014
Vegfd can compensate for loss of Vegfc in zebrafish facial lymphatic sprouting. Development (Cambridge, England)\| PubMed ID: 24903752	2014
An in vivo antilymphatic screen in zebrafish identifies novel inhibitors of mammalian lymphangiogenesis and lymphatic-mediated metastasis. Molecular cancer therapeutics\| PubMed ID: 25053822	2014
An inducible transgene reports activation of macrophages in live zebrafish larvae. Developmental and comparative immunology\| PubMed ID: 26123890	2015
mafba is a downstream transcriptional effector of Vegfc signaling essential for embryonic lymphangiogenesis in zebrafish. Genes & development\| PubMed ID: 26253536	2015
A zebrafish model of inflammatory lymphangiogenesis. Biology open\| PubMed ID: 26369931	2015
Lymphatics, Cancer and Zebrafish. Advances in experimental medicine and biology\| PubMed ID: 27165355	2016
The innate immune cell response to bacterial infection in larval zebrafish is light-regulated. Scientific reports\| PubMed ID: 28978916	2017
Blocking fatty acid-fueled mROS production within macrophages alleviates acute gouty inflammation. The Journal of clinical investigation\| PubMed ID: 29584621	2018
Characterization of Zebrafish Facial Lymphatics. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30242753	2018
Macrophages enhance Vegfa-driven angiogenesis in an embryonic zebrafish tumour xenograft model. Disease models & mechanisms\| PubMed ID: 30396905	2018
Liposome-Mediated Drug Delivery in Larval Zebrafish to Manipulate Macrophage Function. Zebrafish\| PubMed ID: 30724716	2019
Zebrafish facial lymphatics develop through sequential addition of venous and non-venous progenitors. EMBO reports\| PubMed ID: 30877134	2019