Joan Mecsas

Department of Molecular Biology and Microbiology, Tufts University

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 26	2019

Other Publications

Article	Year
Identification of attenuated Yersinia pseudotuberculosis strains and characterization of an orogastric infection in BALB/c mice on day 5 postinfection by signature-tagged mutagenesis. Infection and immunity\| PubMed ID: 11292689	2001
Use of signature-tagged mutagenesis in pathogenesis studies. Current opinion in microbiology\| PubMed ID: 11834366	2002
Requirement of the Yersinia pseudotuberculosis effectors YopH and YopE in colonization and persistence in intestinal and lymph tissues. Infection and immunity\| PubMed ID: 12874339	2003
The proinflammatory response induced by wild-type Yersinia pseudotuberculosis infection inhibits survival of yop mutants in the gastrointestinal tract and Peyer's patches. Infection and immunity\| PubMed ID: 16495522	2006
Yersinia pseudotuberculosis disseminates directly from a replicating bacterial pool in the intestine. The Journal of experimental medicine\| PubMed ID: 16754724	2006
A non-invasive quantitative assay to measure murine intestinal inflammation using the neutrophil marker lactoferrin. Journal of immunological methods\| PubMed ID: 16806255	2006
Yersinia has a tropism for B and T cell zones of lymph nodes that is independent of the type III secretion system. PLoS pathogens\| PubMed ID: 16948531	2006
Mutations in the Yersinia pseudotuberculosis type III secretion system needle protein, YscF, that specifically abrogate effector translocation into host cells. Journal of bacteriology\| PubMed ID: 17071752	2007
Intranasal inoculation of mice with Yersinia pseudotuberculosis causes a lethal lung infection that is dependent on Yersinia outer proteins and PhoP. Infection and immunity\| PubMed ID: 17074849	2007
Oral inoculation with Type III secretion mutants of Yersinia pseudotuberculosis provides protection from oral, intraperitoneal, or intranasal challenge with virulent Yersinia. Vaccine\| PubMed ID: 17194509	2007
Self-regulation of Candida albicans population size during GI colonization. PLoS pathogens\| PubMed ID: 18069889	2007
Effect of age on susceptibility to Salmonella Typhimurium infection in C57BL/6 mice. Journal of medical microbiology\| PubMed ID: 19729455	2009
CD8(+) T cells restrict Yersinia pseudotuberculosis infection: bypass of anti-phagocytosis by targeting antigen-presenting cells. PLoS pathogens\| PubMed ID: 19730693	2009
Effect of MarA-like proteins on antibiotic resistance and virulence in Yersinia pestis. Infection and immunity\| PubMed ID: 19841071	2010
The presence of professional phagocytes dictates the number of host cells targeted for Yop translocation during infection. Cellular microbiology\| PubMed ID: 20148898	2010
ROS-inhibitory activity of YopE is required for full virulence of Yersinia in mice. Cellular microbiology\| PubMed ID: 20148901	2010
A dominant-negative needle mutant blocks type III secretion of early but not late substrates in Yersinia. Molecular microbiology\| PubMed ID: 20199604	2010
The C-terminal tail of Yersinia pseudotuberculosis YopM is critical for interacting with RSK1 and for virulence. Infection and immunity\| PubMed ID: 20368345	2010
Identification and characterization of small-molecule inhibitors of Yop translocation in Yersinia pseudotuberculosis. Antimicrobial agents and chemotherapy\| PubMed ID: 20498321	2010
Small molecule inhibitors of LcrF, a Yersinia pseudotuberculosis transcription factor, attenuate virulence and limit infection in a murine pneumonia model. Infection and immunity\| PubMed ID: 20823209	2010
Development of a vaccinia virus based reservoir-targeted vaccine against Yersinia pestis. Vaccine\| PubMed ID: 20875494	2010
Yersinia pestis AcrAB-TolC in antibiotic resistance and virulence. Antimicrobial agents and chemotherapy\| PubMed ID: 22083483	2012
The NLRP12 inflammasome recognizes Yersinia pestis. Immunity\| PubMed ID: 22840842	2012
Identification of MrtAB, an ABC transporter specifically required for Yersinia pseudotuberculosis to colonize the mesenteric lymph nodes. PLoS pathogens\| PubMed ID: 22876175	2012
A mutant with aberrant extracellular LcrV-YscF interactions fails to form pores and translocate Yop effector proteins but retains the ability to trigger Yop secretion in response to host cel... Journal of bacteriology\| PubMed ID: 23475976	2013
Adhesins and host serum factors drive Yop translocation by yersinia into professional phagocytes during animal infection. PLoS pathogens\| PubMed ID: 23818844	2013
Identifying Yersinia YopH-targeted signal transduction pathways that impair neutrophil responses during in vivo murine infection. Cell host & microbe\| PubMed ID: 24034616	2013
Yersinia pseudotuberculosis uses Ail and YadA to circumvent neutrophils by directing Yop translocation during lung infection. Cellular microbiology\| PubMed ID: 24119087	2014
Mutations in the Pseudomonas aeruginosa needle protein gene pscF confer resistance to phenoxyacetamide inhibitors of the type III secretion system. Antimicrobial agents and chemotherapy\| PubMed ID: 24468789	2014
Intestinal alkaline phosphatase deficiency leads to lipopolysaccharide desensitization and faster weight gain. Infection and immunity\| PubMed ID: 25348635	2015
Robust bioengineered 3D functional human intestinal epithelium. Scientific reports\| PubMed ID: 26374193	2015
A Single Bacterial Immune Evasion Strategy Dismantles Both MyD88 and TRIF Signaling Pathways Downstream of TLR4. Cell host & microbe\| PubMed ID: 26651944	2015
Bacterial Secretion Systems: An Overview. Microbiology spectrum\| PubMed ID: 26999395	2016
Beyond Antibiotics: New Therapeutic Approaches for Bacterial Infections. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 27025826	2016
Klebsiella pneumoniae: Going on the Offense with a Strong Defense. Microbiology and molecular biology reviews : MMBR\| PubMed ID: 27307579	2016
Inhibition of the Injectisome and Flagellar Type III Secretion Systems by INP1855 Impairs Pseudomonas aeruginosa Pathogenicity and Inflammasome Activation. The Journal of infectious diseases\| PubMed ID: 27412581	2016
Fis Is Essential for Yersinia pseudotuberculosis Virulence and Protects against Reactive Oxygen Species Produced by Phagocytic Cells during Infection. PLoS pathogens\| PubMed ID: 27689357	2016
The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation. PLoS pathogens\| PubMed ID: 27911947	2016
Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-β Synthesis Induced by Lipopolysaccharide. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 28461567	2017
Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance. Frontiers in cellular and infection microbiology\| PubMed ID: 28890882	2017
A 3D intestinal tissue model supports Clostridioides difficile germination, colonization, toxin production and epithelial damage. Anaerobe\| PubMed ID: 29462695	2018
Editorial overview: Host-pathogen interactions shaped through evolutionary and regulatory processes. Current opinion in microbiology\| PubMed ID: 29559085	2018
Pre-colonization with the commensal fungus Candida albicans reduces murine susceptibility to Clostridium difficile infection. Gut microbes\| PubMed ID: 29667487	2018
Promises and Challenges of the Type Three Secretion System Injectisome as an Antivirulence Target. EcoSal Plus\| PubMed ID: 30706846	2019
New Age Strategies To Reconstruct Mucosal Tissue Colonization and Growth in Cell Culture Systems. Microbiology spectrum\| PubMed ID: 30848233	2019
Amino acid biosynthetic pathways are required for growth in immunocompromised lungs and are druggable targets during infection. Antimicrobial agents and chemotherapy\| PubMed ID: 31109974	2019
Detection of Cells Translocated with Yersinia Yops in Infected Tissues Using β-Lactamase Fusions. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 31177435	2019
Unraveling neutrophil- interactions during tissue infection. F1000Research\| PubMed ID: 31327994	2019