Xuekun Li

The Children's Hospital, Zhejiang University

Research Area

Biography

Our lab mainly focuses on epigenetic mechanisms especially DNA and RNA modifications in adult neurogenesis and neurological disorders. We have found that 5-hydroxymethylcytosine in genome and N6-methyladenosine in mRNA play essential roles in regulating adult neurogenesis. Our long term aim is to uncover the function of these epigenetic modifications in neuronal developmental and degenerative diseases.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2019

Other Publications

Article	Year
5-hydroxymethylcytosine-mediated DNA demethylation in stem cells and development. Stem cells and development\| PubMed ID: 24400731	2014
From development to diseases: the role of 5hmC in brain. Genomics\| PubMed ID: 25205306	2014
Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway. Nature communications\| PubMed ID: 25420914	2014
The change tendency of PI3K/Akt pathway after spinal cord injury. American journal of translational research\| PubMed ID: 26807170	2015
Genome-wide alteration of 5-hydroxymenthylcytosine in a mouse model of Alzheimer's disease. BMC genomics\| PubMed ID: 27207465	2016
iPSCs: From Bench to Clinical Bed. Stem cells international\| PubMed ID: 27738437	2016
Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis. Human molecular genetics\| PubMed ID: 28398475	2017
Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis. Nature communications\| PubMed ID: 28660881	2017
The Dynamic DNA Demethylation during Postnatal Neuronal Development and Neural Stem Cell Differentiation. Stem cells international\| PubMed ID: 29713349	2018
5-Hydroxymethylcytosine alterations in the human postmortem brains of autism spectrum disorder. Human molecular genetics\| PubMed ID: 29790956	2018
RYBP modulates stability and function of Ring1B through targeting UBE3A. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 30040487	2019
Noncoding RNAs and Base Modifications: Epigenomic Players Implicated in Neurological Disorders and Tumorigenesis. International journal of genomics\| PubMed ID: 30402455	2018
Autism spectrum disorders: autistic phenotypes and complicated mechanisms. World journal of pediatrics : WJP\| PubMed ID: 30607884	2019
Base Modifications: Regulation of Stem Cell Functions and Diseases. Stem cells international\| PubMed ID: 30627173	2018
Long Non-coding RNA in Neuronal Development and Neurological Disorders. Frontiers in genetics\| PubMed ID: 30728830	2018
mA Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2. Genomics, proteomics & bioinformatics\| PubMed ID: 31154015	2019
Long noncoding RNA CCDC144NL-AS1 knockdown induces naïve-like state conversion of human pluripotent stem cells. Stem cell research & therapy\| PubMed ID: 31358062	2019