Kwok-Fai Lau

Kwok-Fai Lau

School of Life Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region

Affiliated withThe Chinese University of Hong Kong, Hong Kong Special Administrative RegionThe Chinese University of Hong Kong

Research Area

Biography

Kwok-Fai Lau is an Associate Professor in the School of Life Sciences, the Chinese University of Hong Kong. He received his B.Sc. (Hons) and Ph.D. degrees from the Hong Kong Baptist University and The Chinese University of Hong Kong, respectively.

After finishing his Ph.D., Dr. Lau joined the Department of Neuroscience at the Institute of Psychiatry in London, UK as a Croucher Foundation research fellow where he developed an interest in the molecular and cellular pathogenesis of Alzheimer’s disease and related dementia. He focused on the roles of Alzheimer’s disease amyloid precursor protein interactors in the disease pathogenesis. In 2007, he returned to his Alma mater as Assistant Professor at the Department of Biochemistry and continued his research on dementia.

Dr. Lau is also interested in neurite development as severe neurite degeneration is a hallmark of many neurodegenerative disorders. Hence, strategies that stimulate neurite outgrowth could promote re-establishment of damaged neuro-connections. His research team has identified several molecules that promote neurite outgrowth.

JoVE Journal Publications

ArticleTotal : 2
Year
An Enhanced Green Fluorescence Protein-based Assay for Studying Neurite Outgrowth in Primary Neurons
Publication title

Cited by 1

2019
2021

Other Publications

Article
Year
Glycogen synthase kinase-3 beta-mediated tau phosphorylation in cultured cell lines.

Neuroreport| PubMed ID: 12598741

2003
2007
2008
2009
2010
2010
2010
2010
Neuronal differentiation of C17.2 neural stem cells induced by a natural flavonoid, baicalin.

Chembiochem : a European journal of chemical biology| PubMed ID: 21290546

2011
2011
2011
2011
2012
2012
2012
2012
2012
DNA microarray expression analysis of baicalin-induced differentiation of C17.2 neural stem cells.

Chembiochem : a European journal of chemical biology| PubMed ID: 22556041

2012
2012
CAG expansion induces nucleolar stress in polyglutamine diseases.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 22847428

2012
FE65 interacts with ADP-ribosylation factor 6 to promote neurite outgrowth.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology| PubMed ID: 24056087

2014
2014
2014
2015
2016
2017
The lysosomal protein cathepsin L is a progranulin protease.

Molecular neurodegeneration| PubMed ID: 28743268

2017
2017
2017
2018
2018
2018
2018
2018
Exo70 Is Essential for Neurite Extension and Survival under Thermal Stress.

The Journal of neuroscience : the official journal of the Society for Neuroscience| PubMed ID: 30209205

2018
Familial ataxia, tremor, and dementia in a polish family with a novel mutation in the CCDC88C gene.

Movement disorders : official journal of the Movement Disorder Society| PubMed ID: 30398676

2019
2018
2019
Attenuation of amyloid-β generation by atypical protein kinase C-mediated phosphorylation of engulfment adaptor PTB domain containing 1 threonine 35.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology| PubMed ID: 31373844

2019
2020
2020
ARF6-Rac1 signaling-mediated neurite outgrowth is potentiated by the neuronal adaptor FE65 through orchestrating ARF6 and ELMO1.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology| PubMed ID: 33047393

2020
2019
CAG RNAs induce DNA damage and apoptosis by silencing expression in polyglutamine degeneration.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 33947817

2021