Alex Freeman

Research Department of Pathology, University College London

Affiliated withUniversity College London

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2019

Other Publications

Article	Year
Clinical features of patients who present with metastatic prostate carcinoma and serum prostate-specific antigen (PSA) levels < 10 ng/mL: the "PSA negative" patients. Cancer\| PubMed ID: 14635070	2003
Differential expression of CD44 during human prostate epithelial cell differentiation. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society\| PubMed ID: 15258184	2004
Comparison of the zones of the human prostate with the seminal vesicle: morphology, immunohistochemistry, and cell kinetics. The Prostate\| PubMed ID: 15389778	2005
Radical prostatectomy: pathology findings in 1001 cases compared with other major series and over time. BJU international\| PubMed ID: 15638892	2005
What surgical resection margins are required to achieve oncological control in men with primary penile cancer? BJU international\| PubMed ID: 16225525	2005
A review of the efficacy of surgical treatment for and pathological changes in patients with chronic scrotal pain. BJU international\| PubMed ID: 17244279	2007
Plexin-B1 mutations in prostate cancer. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18024597	2007
Allelic imbalance at 13q14.2 approximately q14.3 in localized prostate cancer is associated with early biochemical relapse. Cancer genetics and cytogenetics\| PubMed ID: 18036398	2007
Paraneoplastic Cushing's syndrome in prostate cancer: a difficult management problem. BJU international\| PubMed ID: 18070179	2008
MR imaging of prostate after treatment with high-intensity focused ultrasound. Radiology\| PubMed ID: 18223121	2008
Investigating the effects of high-dose phenylephrine in the management of prolonged ischaemic priapism. The journal of sexual medicine\| PubMed ID: 18466270	2008
The feasibility and safety of high-intensity focused ultrasound as salvage therapy for recurrent prostate cancer following external beam radiotherapy. BJU international\| PubMed ID: 18564135	2008
Utility of tissue microarrays for profiling prognostic biomarkers in clinically localized prostate cancer: the expression of BCL-2, E-cadherin, Ki-67 and p53 as predictors of biochemical fai... Asian journal of andrology\| PubMed ID: 19050681	2009
Paraganglioma of the spermatic cord: case report and review of the literature. TheScientificWorldJournal\| PubMed ID: 19112537	2008
Perineural and lymphovascular invasion on prostatic biopsy: pathological assessment and significance. Surgical oncology\| PubMed ID: 19299122	2009
Is it time to consider a role for MRI before prostate biopsy? Nature reviews. Clinical oncology\| PubMed ID: 19333226	2009
Case study: the surgical management of angiokeratoma resulting from radiotherapy for penile cancer. TheScientificWorldJournal\| PubMed ID: 19468654	2009
DNA replication licensing factors and aneuploidy are linked to tumor cell cycle state and clinical outcome in penile carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19920109	2009
The use of high-resolution magnetic resonance imaging in the management of patients presenting with priapism. BJU international\| PubMed ID: 20438564	2010
A novel role for Wnt/Ca2+ signaling in actin cytoskeleton remodeling and cell motility in prostate cancer. PloS one\| PubMed ID: 20454608	2010
PCR-based tissue identification: the UCLH experience. Journal of clinical pathology\| PubMed ID: 21617171	2011
Characterizing clinically significant prostate cancer using template prostate mapping biopsy. The Journal of urology\| PubMed ID: 21679984	2011
Multi-parametric magnetic resonance imaging to rule-in and rule-out clinically important prostate cancer in men at risk: a cohort study. Urologia internationalis\| PubMed ID: 21701136	2011
Epithelioid hemangioma of the penis: case report and review of literature. Journal of medical case reports\| PubMed ID: 21718503	2011
Whole-gland salvage high-intensity focused ultrasound therapy for localized prostate cancer recurrence after external beam radiation therapy. Cancer\| PubMed ID: 22071795	2012
A biopsy simulation study to assess the accuracy of several transrectal ultrasonography (TRUS)-biopsy strategies compared with template prostate mapping biopsies in patients who have undergo... BJU international\| PubMed ID: 22394583	2012
Focal therapy for localised unifocal and multifocal prostate cancer: a prospective development study. The Lancet. Oncology\| PubMed ID: 22512844	2012
Focal salvage therapy for localized prostate cancer recurrence after external beam radiotherapy: a pilot study. Cancer\| PubMed ID: 22907704	2012
Transperineal magnetic resonance image targeted prostate biopsy versus transperineal template prostate biopsy in the detection of clinically significant prostate cancer. The Journal of urology\| PubMed ID: 23063807	2013
CD49f is an efficient marker of monolayer- and spheroid colony-forming cells of the benign and malignant human prostate. PloS one\| PubMed ID: 23071686	2012
Do low-grade and low-volume prostate cancers bear the hallmarks of malignancy? The Lancet. Oncology\| PubMed ID: 23117005	2012
Prostate cancer risk inflation as a consequence of image-targeted biopsy of the prostate: a computer simulation study. European urology\| PubMed ID: 23312572	2014
Genital lichen sclerosus/balanitis xerotica obliterans in men with penile carcinoma: a critical analysis. BJU international\| PubMed ID: 23356463	2013
Evaluation of retained testes in adolescent girls and women with complete androgen insensitivity syndrome. Radiology\| PubMed ID: 23533290	2013
Prognostic Gleason grade grouping: data based on the modified Gleason scoring system. BJU international\| PubMed ID: 23578229	2013
The accuracy of multiparametric MRI in men with negative biopsy and elevated PSA level--can it rule out clinically significant prostate cancer? Urologic oncology\| PubMed ID: 24055430	2014
Performance of multiparametric MRI in men at risk of prostate cancer before the first biopsy: a paired validating cohort study using template prostate mapping biopsies as the reference stand... Prostate cancer and prostatic diseases\| PubMed ID: 24126797	2014
Prostate cancer tumour features on template prostate-mapping biopsies: implications for focal therapy. European urology\| PubMed ID: 24207133	2014
The PICTURE study -- prostate imaging (multi-parametric MRI and Prostate HistoScanning™) compared to transperineal ultrasound guided biopsy for significant prostate cancer risk evaluation. Contemporary clinical trials\| PubMed ID: 24291455	2014
Quantitative analysis of BTF3, HINT1, NDRG1 and ODC1 protein over-expression in human prostate cancer tissue. PloS one\| PubMed ID: 24386364	2013
Changes in mast cell number and stem cell factor expression in human skin after radiotherapy for breast cancer. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology\| PubMed ID: 24746564	2014
Loss of expression of the tumour suppressor gene AIMP3 predicts survival following radiotherapy in muscle-invasive bladder cancer. International journal of cancer. Journal international du cancer\| PubMed ID: 24917520	2015
Can multiparametric magnetic resonance imaging predict upgrading of transrectal ultrasound biopsy results at more definitive histology? Urologic oncology\| PubMed ID: 24981993	2014
Gonadotrophin-independent precocious puberty associated with later diagnosis of testicular embryonal carcinoma. Hormone research in paediatrics\| PubMed ID: 25012595	2014
A prospective development study investigating focal irreversible electroporation in men with localised prostate cancer: Nanoknife Electroporation Ablation Trial (NEAT). Contemporary clinical trials\| PubMed ID: 25072507	2014
Logistic regression model for diagnosis of transition zone prostate cancer on multi-parametric MRI. European radiology\| PubMed ID: 25226842	2015
Microstructural characterization of normal and malignant human prostate tissue with vascular, extracellular, and restricted diffusion for cytometry in tumours magnetic resonance imaging. Investigative radiology\| PubMed ID: 25426656	2015
Identifying the index lesion with template prostate mapping biopsies. The Journal of urology\| PubMed ID: 25463987	2015
Epigenetics markers of metastasis and HPV-induced tumorigenesis in penile cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 25538261	2015
An unusual swelling in the male perineum. BMJ case reports\| PubMed ID: 25612751	2015
Zone-specific logistic regression models improve classification of prostate cancer on multi-parametric MRI. European radiology\| PubMed ID: 25680730	2015
Focal Ablation Targeted to the Index Lesion in Multifocal Localised Prostate Cancer: a Prospective Development Study. European urology\| PubMed ID: 25682339	2015
Visually directed vs. software-based targeted biopsy compared to transperineal template mapping biopsy in the detection of clinically significant prostate cancer. Urologic oncology\| PubMed ID: 26195330	2015
What Burden of Prostate Cancer Can Radiologists Rule Out on Multiparametric Magnetic Resonance Imaging? A Sensitivity Analysis Based on Varying the Target Condition in Template Prostate Mapp... Urology\| PubMed ID: 26253041	2015
CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma. Cancer research\| PubMed ID: 27325650	2016
Does true Gleason pattern 3 merit its cancer descriptor? Nature reviews. Urology\| PubMed ID: 27530265	2016
F-FECH PET/CT to Assess Clinically Significant Disease in Prostate Cancer: Correlation With Maximum and Total Cancer Core Length Obtained via MRI-Guided Template Mapping Biopsies. AJR. American journal of roentgenology\| PubMed ID: 27611962	2016
Prostate-specific antigen vs. magnetic resonance imaging parameters for assessing oncological outcomes after high intensity-focused ultrasound focal therapy for localized prostate cancer. Urologic oncology\| PubMed ID: 27663393	2017
Nanoknife Electroporation Ablation Trial: A Prospective Development Study Investigating Focal Irreversible Electroporation for Localized Prostate Cancer. The Journal of urology\| PubMed ID: 27697580	2017
Glansectomy and Split-thickness Skin Graft for Penile Cancer. European urology\| PubMed ID: 27746062	2018
The Effect of Dutasteride on Magnetic Resonance Imaging Defined Prostate Cancer: MAPPED-A Randomized, Placebo Controlled, Double-Blind Clinical Trial. The Journal of urology\| PubMed ID: 27871928	2017
Diagnostic accuracy of multi-parametric MRI and TRUS biopsy in prostate cancer (PROMIS): a paired validating confirmatory study. Lancet (London, England)\| PubMed ID: 28110982	2017
UroMark-a urinary biomarker assay for the detection of bladder cancer. Clinical epigenetics\| PubMed ID: 28163793	2017
Port-Site Metastases After Robotic Radical Cystectomy: A Systematic Review and Management Options. Clinical genitourinary cancer\| PubMed ID: 28209455	2017
The PICTURE study: diagnostic accuracy of multiparametric MRI in men requiring a repeat prostate biopsy. British journal of cancer\| PubMed ID: 28350785	2017
Spectrum of metastatic and nonmetastatic skeletal findings with dual-phase 18F-FECH PET/CT in patients with biochemical relapse of prostate cancer. Nuclear medicine communications\| PubMed ID: 28379896	2017
Apparatus for Histological Validation of and Magnetic Resonance Imaging of the Human Prostate. Frontiers in oncology\| PubMed ID: 28393049	2017
Management of Radiologically Indeterminate Magnetic Resonance Imaging Signals in Men at Risk of Prostate Cancer. European urology focus\| PubMed ID: 28753883	2019
Predictive factors for local recurrence after glansectomy and neoglans reconstruction for penile squamous cell carcinoma. Urologic oncology\| PubMed ID: 28882673	2018
A multicentre randomised controlled trial assessing whether MRI-targeted biopsy is non-inferior to standard transrectal ultrasound guided biopsy for the diagnosis of clinically significant p... BMJ open\| PubMed ID: 29025845	2017
The CADMUS trial - Multi-parametric ultrasound targeted biopsies compared to multi-parametric MRI targeted biopsies in the diagnosis of clinically significant prostate cancer. Contemporary clinical trials\| PubMed ID: 29108869	2018
Characterizing indeterminate (Likert-score 3/5) peripheral zone prostate lesions with PSA density, PI-RADS scoring and qualitative descriptors on multiparametric MRI. The British journal of radiology\| PubMed ID: 29189042	2018
Phenotypic appearances of prostate utilizing PET-MRI and PET-CT with 68Ga-PSMA, radiolabelled choline and 68Ga-DOTATATE. Nuclear medicine communications\| PubMed ID: 29384832	2018
MRI-Targeted or Standard Biopsy for Prostate-Cancer Diagnosis. The New England journal of medicine\| PubMed ID: 29552975	2018
Patient Reported Outcome Measures for Transperineal Template Prostate Mapping Biopsies in the PICTURE Study. The Journal of urology\| PubMed ID: 29940251	2018
Accuracy of Transperineal Targeted Prostate Biopsies, Visual Estimation and Image Fusion in Men Needing Repeat Biopsy in the PICTURE Trial. The Journal of urology\| PubMed ID: 30017964	2018
Multiparametric MRI to improve detection of prostate cancer compared with transrectal ultrasound-guided prostate biopsy alone: the PROMIS study. Health technology assessment (Winchester, England)\| PubMed ID: 30040065	2018
Immunohistochemical biomarker validation in highly selective needle biopsy microarrays derived from mpMRI-characterized prostates. The Prostate\| PubMed ID: 30073682	2018
Urine-derived lymphocytes as a non-invasive measure of the bladder tumor immune microenvironment. The Journal of experimental medicine\| PubMed ID: 30257862	2018
Prostate Imaging Compared to Transperineal Ultrasound-guided biopsy for significant prostate cancer Risk Evaluation (PICTURE): a prospective cohort validating study assessing Prostate HistoS... Prostate cancer and prostatic diseases\| PubMed ID: 30279583	2019
Prostate cancer diagnostic pathway: Is a one-stop cognitive MRI targeted biopsy service a realistic goal in everyday practice? A pilot cohort in a tertiary referral centre in the UK. BMJ open\| PubMed ID: 30361408	2018
VERDICT-AMICO: Ultrafast fitting algorithm for non-invasive prostate microstructure characterization. NMR in biomedicine\| PubMed ID: 30378195	2019
Quality assurance guidance for scoring and reporting for pathologists and laboratories undertaking clinical trial work. The journal of pathology. Clinical research\| PubMed ID: 30407751	2019
Multi-parametric MRI zone-specific diagnostic model performance compared with experienced radiologists for detection of prostate cancer. European radiology\| PubMed ID: 30456585	2019
The SmartTarget Biopsy Trial: A Prospective, Within-person Randomised, Blinded Trial Comparing the Accuracy of Visual-registration and Magnetic Resonance Imaging/Ultrasound Image-fusion Targ... European urology\| PubMed ID: 30527787	2019
Dermatoscopic findings of penile intraepithelial neoplasia: Bowenoid papulosis, Bowen disease and erythroplasia of Queyrat. The Australasian journal of dermatology\| PubMed ID: 30585302	2019
Training and accreditation standards for pathologists undertaking clinical trial work. The journal of pathology. Clinical research\| PubMed ID: 30680942	2019
Pathological Findings and Magnetic Resonance Imaging Concordance at Salvage Radical Prostatectomy for Local Recurrence following Partial Ablation Using High Intensity Focused Ultrasound. The Journal of urology\| PubMed ID: 30730409	2019
Medium-term oncological outcomes in a large cohort of men treated with either focal or hemi-ablation using high-intensity focused ultrasonography for primary localized prostate cancer. BJU international\| PubMed ID: 30753756	2019
VERDICT MRI validation in fresh and fixed prostate specimens using patient-specific moulds for histological and MR alignment. NMR in biomedicine\| PubMed ID: 30779863	2019
PEOPLE: PatiEnt prOstate samPLes for rEsearch, a tissue collection pathway utilizing magnetic resonance imaging data to target tumor and benign tissue in fresh radical prostatectomy specimen... The Prostate\| PubMed ID: 30807665	2019
Primary Squamous Cell Carcinoma of the Male Proximal Urethra: Outcomes from a Single Centre. European urology focus\| PubMed ID: 30853605	2019
Targeted biopsy of the prostate: does this result in improvement in detection of high-grade cancer or the occurrence of the Will Rogers phenomenon? BJU international\| PubMed ID: 31081983	2019
Machine learning classifiers can predict Gleason pattern 4 prostate cancer with greater accuracy than experienced radiologists. European radiology\| PubMed ID: 31187216	2019
NeuroSAFE robot-assisted laparoscopic prostatectomy versus standard robot-assisted laparoscopic prostatectomy for men with localised prostate cancer (NeuroSAFE PROOF): protocol for a randomi... BMJ open\| PubMed ID: 31189680	2019
Molecular and histopathology directed therapy for advanced bladder cancer. Nature reviews. Urology\| PubMed ID: 31289379	2019
A Multicentre Analysis of the Detection of Clinically Significant Prostate Cancer Following Transperineal Image-fusion Targeted and Nontargeted Systematic Prostate Biopsy in Men at Risk. European urology oncology\| PubMed ID: 31411968	2019
Prediction of significant prostate cancer in biopsy-naïve men: Validation of a novel risk model combining MRI and clinical parameters and comparison to an ERSPC risk calculator and PI-RADS. PloS one\| PubMed ID: 31450235	2019
Correction to: Machine learning classifiers can predict Gleason pattern 4 prostate cancer with greater accuracy than experienced radiologists. European radiology\| PubMed ID: 31506815	2019