Ramnik J. Xavier

Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School

Affiliated withMassachusetts General Hospital, Harvard Medical School

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 8	2011

Other Publications

Article	Year
Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice. Gastroenterology\| PubMed ID: 11781288	2002
Decreased bone density in splenectomized Gaucher patients receiving enzyme replacement therapy. Blood cells, molecules & diseases\| PubMed ID: 12064924	2002
Transforming growth factor-beta mediates intestinal healing and susceptibility to injury in vitro and in vivo through epithelial cells. The American journal of pathology\| PubMed ID: 12547717	2003
Colonic epithelial functional phenotype varies with type and phase of experimental colitis. Gastroenterology\| PubMed ID: 12851880	2003
The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death. The Journal of biological chemistry\| PubMed ID: 15075335	2004
Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells. FEBS letters\| PubMed ID: 15670823	2005
Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation. Molecular and cellular biology\| PubMed ID: 16809782	2006
Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17172448	2006
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nature genetics\| PubMed ID: 17435756	2007
Molecular pathogenesis of inflammatory bowel disease: genotypes, phenotypes and personalized medicine. Annals of medicine\| PubMed ID: 17457716	2007
AKAP13, a RhoA GTPase-specific guanine exchange factor, is a novel regulator of TLR2 signaling. The Journal of biological chemistry\| PubMed ID: 17878165	2007
DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact. Cellular signalling\| PubMed ID: 17980554	2008
IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. The Journal of clinical investigation\| PubMed ID: 18172556	2008
Identification of host proteins required for HIV infection through a functional genomic screen. Science (New York, N.Y.)\| PubMed ID: 18187620	2008
Defective signal transduction in B lymphocytes lacking presenilin proteins. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18195359	2008
Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis. Gut\| PubMed ID: 18272545	2008
Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis. Endocrine-related cancer\| PubMed ID: 18310291	2008
SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter. Biochemistry\| PubMed ID: 18484747	2008
Neither hide nor hair: the difficulty of identifying useful disease biomarkers. Gastroenterology\| PubMed ID: 18486617	2008
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nature genetics\| PubMed ID: 18587394	2008
Genome-wide association studies: a new window into immune-mediated diseases. Nature reviews. Immunology\| PubMed ID: 18654571	2008
Hoxc6 is overexpressed in gastrointestinal carcinoids and interacts with JunD to regulate tumor growth. Gastroenterology\| PubMed ID: 18655788	2008
RNA interference screen for human genes associated with West Nile virus infection. Nature\| PubMed ID: 18690214	2008
CARMA3 mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cells. American journal of respiratory cell and molecular biology\| PubMed ID: 18757306	2009
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature\| PubMed ID: 18849966	2008
Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant. PloS one\| PubMed ID: 18852889	2008
Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18981407	2008
On the level: IRGM gene function is all about expression. Autophagy\| PubMed ID: 19029815	2009
HIF-1alpha and HIF-2alpha have divergent roles in colon cancer. International journal of cancer. Journal international du cancer\| PubMed ID: 19030186	2009
Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell\| PubMed ID: 19109899	2008
Differential requirement for CARMA1 in agonist-selected T-cell development. European journal of immunology\| PubMed ID: 19130560	2009
Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nature genetics\| PubMed ID: 19165925	2008
A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. Cell host & microbe\| PubMed ID: 19286138	2009
A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19342671	2009
The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements. Experimental cell research\| PubMed ID: 19371741	2009
An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia. Nucleic acids research\| PubMed ID: 19491311	2009
Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. PLoS genetics\| PubMed ID: 19557189	2009
Autophagy at the gut interface: mucosal responses to stress and the consequences for inflammatory bowel diseases. Inflammatory bowel diseases\| PubMed ID: 19575363	2010
A genome-wide genetic screen for host factors required for hepatitis C virus propagation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19717417	2009
Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly. Cellular microbiology\| PubMed ID: 19747213	2010
Autophagy, immunity and human disease. Current opinion in gastroenterology\| PubMed ID: 19826372	2009
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature\| PubMed ID: 19865172	2009
Common variants at five new loci associated with early-onset inflammatory bowel disease. Nature genetics\| PubMed ID: 19915574	2009
The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell\| PubMed ID: 20064371	2009
Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nature genetics\| PubMed ID: 20228799	2010
Gene enrichment profiles reveal T-cell development, differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor. Blood\| PubMed ID: 20410506	2010
Characterization and analysis of human chordoma cell lines. Spine\| PubMed ID: 20461036	2010
A systems biology viewpoint on autophagy in health and disease. Current opinion in gastroenterology\| PubMed ID: 20571384	2010
Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20616063	2011
A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions. Developmental cell\| PubMed ID: 20627085	2010
Wnt signaling regulates mitochondrial physiology and insulin sensitivity. Genes & development\| PubMed ID: 20634317	2010
Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20660724	2010
Crohn disease: a current perspective on genetics, autophagy and immunity. Autophagy\| PubMed ID: 20729636	2011
Human IRGM gene "to be or not to be". Seminars in immunopathology\| PubMed ID: 20737271	2010
NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis. Inflammatory bowel diseases\| PubMed ID: 20872834	2011
LRRK2 is involved in the IFN-gamma response and host response to pathogens. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20921534	2010
Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection. The Journal of cell biology\| PubMed ID: 21041446	2010
Failure and exploitation of autophagy in human pathologies-cellular integrity between inflammation, infection, and cell survival. Seminars in immunopathology\| PubMed ID: 21107575	2010
Control and manipulation of pathogens with an optical trap for live cell imaging of intercellular interactions. PloS one\| PubMed ID: 21217821	2010
Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology. PLoS genetics\| PubMed ID: 21249183	2011
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nature genetics\| PubMed ID: 21297633	2011
Bacterial and host determinants of MAL activation upon EPEC infection: the roles of Tir, ABRA, and FLRT3. PLoS pathogens\| PubMed ID: 21490959	2011
Recurrent chromosomal copy number alterations in sporadic chordomas. PloS one\| PubMed ID: 21602918	2011
Leucine-rich repeat (LRR) proteins: integrators of pattern recognition and signaling in immunity. Autophagy\| PubMed ID: 21606681	2011
MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21646294	2011
A Francisella tularensis locus required for spermine responsiveness is necessary for virulence. Infection and immunity\| PubMed ID: 21670171	2011
Genetics and pathogenesis of inflammatory bowel disease. Nature\| PubMed ID: 21677747	2011
HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response. PloS one\| PubMed ID: 21949742	2011
Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease. Nature genetics\| PubMed ID: 21983784	2011
Genome-wide expression profiling implicates a MAST3-regulated gene set in colonic mucosal inflammation of ulcerative colitis patients. Inflammatory bowel diseases\| PubMed ID: 21994190	2011
Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature\| PubMed ID: 22020285	2011
CARMA1 is necessary for optimal T cell responses in a murine model of allergic asthma. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22075698	2011
Tribbles 2 (Trib2) is a novel regulator of toll-like receptor 5 signaling. Inflammatory bowel diseases\| PubMed ID: 22271508	2012
Genome-wide siRNA screen for mediators of NF-ÎºB activation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22308454	2012