Jeffrey D. Varner

Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 16	2019

Other Publications

Article	Year
Systems biology and the mathematical modelling of antibody-directed enzyme prodrug therapy (ADEPT). Systems biology\| PubMed ID: 16986273	2005
Stochastic reaction-diffusion simulation of enzyme compartmentalization reveals improved catalytic efficiency for a synthetic metabolic pathway. Metabolic engineering\| PubMed ID: 17601761	2007
Computationally derived points of fragility of a human cascade are consistent with current therapeutic strategies. PLoS computational biology\| PubMed ID: 17658944	2007
A test of highly optimized tolerance reveals fragile cell-cycle mechanisms are molecular targets in clinical cancer trials. PloS one\| PubMed ID: 18431497	2008
Engineering the spatial organization of metabolic enzymes: mimicking nature's synergy. Current opinion in biotechnology\| PubMed ID: 18725290	2008
Analysis of the molecular networks in androgen dependent and independent prostate cancer revealed fragile and robust subsystems. PloS one\| PubMed ID: 20126616	2010
Arsenic trioxide cooperates with all trans retinoic acid to enhance mitogen-activated protein kinase activation and differentiation in PML-RARalpha negative human myeloblastic leukemia cells... Leukemia & lymphoma\| PubMed ID: 20615082	2010
Ensembles of signal transduction models using Pareto Optimal Ensemble Techniques (POETs). Biotechnology journal\| PubMed ID: 20665647	2010
Ensembles of uncertain mathematical models can identify network response to therapeutic interventions. Molecular bioSystems\| PubMed ID: 20844798	2010
Modeling and analysis of retinoic acid induced differentiation of uncommitted precursor cells. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 21437295	2011
Interferon regulatory factor-1 binds c-Cbl, enhances mitogen activated protein kinase signaling and promotes retinoic acid-induced differentiation of HL-60 human myelo-monoblastic leukemia c... Leukemia & lymphoma\| PubMed ID: 21740303	2011
A review of the mammalian unfolded protein response. Biotechnology and bioengineering\| PubMed ID: 21809331	2011
Computational modeling and analysis of insulin induced eukaryotic translation initiation. PLoS computational biology\| PubMed ID: 22102801	2011
Multiscale models of breast cancer progression. Annals of biomedical engineering\| PubMed ID: 23008097	2012
Hierarchical approaches for systems modeling in cardiac development. Wiley interdisciplinary reviews. Systems biology and medicine\| PubMed ID: 23463736	2013
The Src-family kinase inhibitor PP2 rescues inducible differentiation events in emergent retinoic acid-resistant myeloblastic leukemia cells. PloS one\| PubMed ID: 23554907	2013
Physicochemical regulation of endothelial sprouting in a 3D microfluidic angiogenesis model. Journal of biomedical materials research. Part A\| PubMed ID: 23559519	2013
Ubiquibodies, synthetic E3 ubiquitin ligases endowed with unnatural substrate specificity for targeted protein silencing. The Journal of biological chemistry\| PubMed ID: 24474696	2014
Retinoic acid therapy resistance progresses from unilineage to bilineage in HL-60 leukemic blasts. PloS one\| PubMed ID: 24922062	2014
GW5074 and PP2 kinase inhibitors implicate nontraditional c-Raf and Lyn function as drivers of retinoic acid-induced maturation. Cellular signalling\| PubMed ID: 25817574	2015
Generating Effective Models and Parameters for RNA Genetic Circuits. ACS synthetic biology\| PubMed ID: 26046393	2015
6-Formylindolo(3,2-b)Carbazole (FICZ) Modulates the Signalsome Responsible for RA-Induced Differentiation of HL-60 Myeloblastic Leukemia Cells. PloS one\| PubMed ID: 26287494	2015
Induced myelomonocytic differentiation in leukemia cells is accompanied by noncanonical transcription factor expression. FEBS open bio\| PubMed ID: 26566473	2015
Population Heterogeneity in the Epithelial to Mesenchymal Transition Is Controlled by NFAT and Phosphorylated Sp1. PLoS computational biology\| PubMed ID: 28027307	2016
JuPOETs: a constrained multiobjective optimization approach to estimate biochemical model ensembles in the Julia programming language. BMC systems biology\| PubMed ID: 28122561	2017
An Effective Model of the Retinoic Acid Induced HL-60 Differentiation Program. Scientific reports\| PubMed ID: 29085021	2017
Reduced order modeling and analysis of the human complement system. PloS one\| PubMed ID: 29155837	2017
Potential for subsets of wt-NPM1 primary AML blasts to respond to retinoic acid treatment. Oncotarget\| PubMed ID: 29423110	2018
Src family kinase inhibitor bosutinib enhances retinoic acid-induced differentiation of HL-60 leukemia cells. Leukemia & lymphoma\| PubMed ID: 29569971	2018
Sequence Specific Modeling of E. coli Cell-Free Protein Synthesis. ACS synthetic biology\| PubMed ID: 29944340	2018
Dynamic Optimization with Particle Swarms (DOPS): a meta-heuristic for parameter estimation in biochemical models. BMC systems biology\| PubMed ID: 30314484	2018
Multi-scale computational study of the Warburg effect, reverse Warburg effect and glutamine addiction in solid tumors. PLoS computational biology\| PubMed ID: 30532226	2018
Retinoic acid and 6-formylindolo(3,2-b)carbazole (FICZ) combination therapy reveals putative targets for enhancing response in non-APL AML. Leukemia & lymphoma\| PubMed ID: 30570341	2019
Analysis of the role of thrombomodulin in all-trans retinoic acid treatment of coagulation disorders in cancer patients. Theoretical biology & medical modelling\| PubMed ID: 30764845	2019
Improving designer glycan production in through model-guided metabolic engineering. Metabolic engineering communications\| PubMed ID: 31008057	2019