Frank Wuest

Department of Oncology, University of Alberta

Research Area

Biography

Frank Wuest has not added Biography.
If you are Frank Wuest and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 3	2020

Other Publications

Article	Year
Synthesis and cyclooxygenase inhibition of various (aryl-1,2,3-triazole-1-yl)-methanesulfonylphenyl derivatives. Bioorganic & medicinal chemistry\| PubMed ID: 19157881	2009
[Not Available]. Journal of oncology\| PubMed ID: 19551155	2009
Iodine-124: a promising positron emitter for organic PET chemistry. Molecules (Basel, Switzerland)\| PubMed ID: 20428073	2010
Synthesis and application of 4-[(18)F]fluorobenzylamine: A versatile building block for the preparation of PET radiotracers. Organic & biomolecular chemistry\| PubMed ID: 20740244	2010
Synthesis of hypoxia imaging agent 1-(5-deoxy-5-fluoro-α-D-arabinofuranosyl)-2-nitroimidazole using microfluidic technology. Nuclear medicine and biology\| PubMed ID: 21315279	2011
Synthesis and evaluation of 1,5-diaryl-substituted tetrazoles as novel selective cyclooxygenase-2 (COX-2) inhibitors. Bioorganic & medicinal chemistry letters\| PubMed ID: 21316237	2011
Radiopharmacological evaluation of 6-deoxy-6-[18F]fluoro-D-fructose as a radiotracer for PET imaging of GLUT5 in breast cancer. Nuclear medicine and biology\| PubMed ID: 21531283	2011
Radiolabeling of phosphatidylserine-binding peptides with prosthetic groups N-[6-(4-[18F]fluorobenzylidene)aminooxyhexyl]maleimide ([18F]FBAM) and N-succinimidyl-4-[18F]fluorobenzoate ([18F]... Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine\| PubMed ID: 21571539	2011
Cyclooxygenase-2 inhibitors: a literature and patent review (2009 - 2010). Expert opinion on therapeutic patents\| PubMed ID: 21714592	2011
Copper-free click chemistry with the short-lived positron emitter fluorine-18. Organic & biomolecular chemistry\| PubMed ID: 21938294	2011
Radiotracers based on technetium-94m. Current radiopharmaceuticals\| PubMed ID: 22191648	2011
Novel 5-substituted 1H-tetrazoles as cyclooxygenase-2 (COX-2) inhibitors. Bioorganic & medicinal chemistry letters\| PubMed ID: 22341941	2012
Microfluidic technology: an economical and versatile approach for the synthesis of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET). Bioorganic & medicinal chemistry letters\| PubMed ID: 22342141	2012
Synthesis and evaluation of fluorobenzoylated di- and tripeptides as inhibitors of cyclooxygenase-2 (COX-2). Bioorganic & medicinal chemistry\| PubMed ID: 22386983	2012
Fluorine- and rhenium-containing geldanamycin derivatives as leads for the development of molecular probes for imaging Hsp90. Organic & biomolecular chemistry\| PubMed ID: 22825378	2012
Comparative functional evaluation of immunocompetent mouse breast cancer models established from PyMT-tumors using small animal PET with [(18)F]FDG and [(18)F]FLT. American journal of nuclear medicine and molecular imaging\| PubMed ID: 23133804	2012
Hybrid fluorescent conjugates of COX-2 inhibitors: search for a COX-2 isozyme imaging cancer biomarker. Bioorganic & medicinal chemistry letters\| PubMed ID: 23200247	2013
Fully automated synthesis of 4-[18F]fluorobenzylamine based on borohydride/NiCl2 reduction. Nuclear medicine and biology\| PubMed ID: 23306136	2013
Synthesis and evaluation of an 18F-labelled norbornene derivative for copper-free click chemistry reactions. Organic & biomolecular chemistry\| PubMed ID: 23640655	2013
1,4-Diaryl-substituted triazoles as cyclooxygenase-2 inhibitors: Synthesis, biological evaluation and molecular modeling studies. Bioorganic & medicinal chemistry\| PubMed ID: 23706267	2013
Synthesis, characterisation and evaluation of a novel copper-64 complex with selective uptake in EMT-6 cells under hypoxic conditions. Dalton transactions (Cambridge, England : 2003)\| PubMed ID: 23838751	2013
Synthesis and radiopharmacological evaluation of a high-affinity and metabolically stabilized 18F-labeled bombesin analogue for molecular imaging of gastrin-releasing peptide receptor-expres... Nuclear medicine and biology\| PubMed ID: 23969085	2013
Application of [18F]FDG in radiolabeling reactions using microfluidic technology. Lab on a chip\| PubMed ID: 24056916	2013
Radiotracers for molecular imaging of cyclooxygenase-2 (COX-2) enzyme. Current medicinal chemistry\| PubMed ID: 24059237	2013
Synthesis of three 18F-labelled cyclooxygenase-2 (COX-2) inhibitors based on a pyrimidine scaffold. Organic & biomolecular chemistry\| PubMed ID: 24145766	2013
Positron emission tomography radiotracers for imaging hypoxia. Journal of labelled compounds & radiopharmaceuticals\| PubMed ID: 24285331	2013
Fluorophore-labeled cyclooxygenase-2 inhibitors for the imaging of cyclooxygenase-2 overexpression in cancer: synthesis and biological studies. ChemMedChem\| PubMed ID: 24376205	2014
Do nitric oxide-releasing drugs offer a potentially new paradigm for the management of cardiovascular risks in diabetes? Expert review of cardiovascular therapy\| PubMed ID: 24725228	2014
Automated synthesis and dosimetry of 6-deoxy-6-[(18)F]fluoro-D-fructose (6-[(18)F]FDF): a radiotracer for imaging of GLUT5 in breast cancer. American journal of nuclear medicine and molecular imaging\| PubMed ID: 24795839	2014
Synthesis and evaluation of 2-amino-5-(4-[(18)F]fluorophenyl)pent-4-ynoic acid ([(18)F]FPhPA): a novel (18)F-labeled amino acid for oncologic PET imaging. Nuclear medicine and biology\| PubMed ID: 24993371	2014
Improved soluble expression of a single-chain antibody fragment in E. coli for targeting CA125 in epithelial ovarian cancer. Protein expression and purification\| PubMed ID: 25079010	2014
18F-Labeled Peptides: The Future Is Bright. Molecules (Basel, Switzerland)\| PubMed ID: 25493636	2014
Rerouting the metabolic pathway of (18)F-labeled peptides: the influence of prosthetic groups. Bioconjugate chemistry\| PubMed ID: 25572982	2015
Erratum: Automated synthesis and dosimetry of 6-deoxy-6-[(18)F]fluoro-D-fructose (6-[(18)F]FDF): a radiotracer for imaging of GLUT5 in breast cancer. American journal of nuclear medicine and molecular imaging\| PubMed ID: 25625031	2015
Sonogashira cross-coupling reaction with 4-[18F]fluoroiodobenzene for rapid 18F-labelling of peptides. Chemical communications (Cambridge, England)\| PubMed ID: 25650065	2015
Diaryl-Substituted (Dihydro)pyrrolo[3,2,1-hi]indoles, a Class of Potent COX-2 Inhibitors with Tricyclic Core Structure. The Journal of organic chemistry\| PubMed ID: 25909690	2015
Immuno-PET of epithelial ovarian cancer: harnessing the potential of CA125 for non-invasive imaging. EJNMMI research\| PubMed ID: 26116121	2014
Radiopharmacological evaluation of (18)F-labeled phosphatidylserine-binding peptides for molecular imaging of apoptosis. Nuclear medicine and biology\| PubMed ID: 26205076	2015
18F-Labeled wild-type annexin V: comparison of random and site-selective radiolabeling methods. Amino acids\| PubMed ID: 26255286	2016
Targeting lysyl oxidase for molecular imaging in breast cancer. Breast cancer research : BCR\| PubMed ID: 26265048	2015
Design, Synthesis, and Evaluation of an (18)F-Labeled Radiotracer Based on Celecoxib-NBD for Positron Emission Tomography (PET) Imaging of Cyclooxygenase-2 (COX-2). ChemMedChem\| PubMed ID: 26287271	2015
Synthesis and structural identification of fluorine-18 labeled parathyroid hormone. Journal of labelled compounds & radiopharmaceuticals\| PubMed ID: 26356136	2015
Preclinical 89Zr Immuno-PET of High-Grade Serous Ovarian Cancer and Lymph Node Metastasis. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 26837339	2016
Design and synthesis of [(125)I]Pyricoxib: A novel (125)I-labeled cyclooxygenase-2 (COX-2) inhibitors. Bioorganic & medicinal chemistry letters\| PubMed ID: 26898334	2016
Metabolically Stabilized (68)Ga-NOTA-Bombesin for PET Imaging of Prostate Cancer and Influence of Protease Inhibitor Phosphoramidon. Molecular pharmaceutics\| PubMed ID: 26973098	2016
PET imaging of cyclooxygenase-2 (COX-2) in a pre-clinical colorectal cancer model. EJNMMI research\| PubMed ID: 27112768	2016
Automated synthesis of [(18)F]DCFPyL via direct radiofluorination and validation in preclinical prostate cancer models. EJNMMI research\| PubMed ID: 27142881	2016
Pyrimidine-based fluorescent COX-2 inhibitors: synthesis and biological evaluation. Organic & biomolecular chemistry\| PubMed ID: 27383140	2016
Synthesis and pre-clinical evaluation of an (18)F-labeled single-chain antibody fragment for PET imaging of epithelial ovarian cancer. American journal of nuclear medicine and molecular imaging\| PubMed ID: 27508105	2016
Structure-activity relationship of novel series of 1,5-disubstituted tetrazoles as cyclooxygenase-2 inhibitors: Design, synthesis, bioassay screening and molecular docking studies. Bioorganic & medicinal chemistry letters\| PubMed ID: 27567369	2016
Targeting Phosphatidylserine with a Cu-Labeled Peptide for Molecular Imaging of Apoptosis. Molecular pharmaceutics\| PubMed ID: 27608290	2016
Fluorescent Hexose Conjugates Establish Stringent Stereochemical Requirement by GLUT5 for Recognition and Transport of Monosaccharides. ACS chemical biology\| PubMed ID: 28205432	2017
In situ click chemistry generation of cyclooxygenase-2 inhibitors. Nature communications\| PubMed ID: 28232747	2017
Implications for breast cancer treatment from increased autotaxin production in adipose tissue after radiotherapy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 28539367	2017
Targeting Prostate-Specific Membrane Antigen (PSMA) with F-18-Labeled Compounds: the Influence of Prosthetic Groups on Tumor Uptake and Clearance Profile. Molecular imaging and biology\| PubMed ID: 28639122	2017
Molecular Imaging of GLUT1 and GLUT5 in Breast Cancer: A Multitracer Positron Emission Tomography Imaging Study in Mice. Molecular pharmacology\| PubMed ID: 29142019	2018
F-Radiolabeling and In Vivo Analysis of SiFA-Derivatized Polymeric Core-Shell Nanoparticles. Bioconjugate chemistry\| PubMed ID: 29202229	2018
Molecular imaging of platelet-derived growth factor receptor-alpha (PDGFRα) in papillary thyroid cancer using immuno-PET. Nuclear medicine and biology\| PubMed ID: 29367096	2018
Impact of structural alterations on the radiopharmacological profile of F-labeled pyrimidines as cyclooxygenase-2 (COX-2) imaging agents. Nuclear medicine and biology\| PubMed ID: 29800798	2018
Expression and function of hexose transporters GLUT1, GLUT2, and GLUT5 in breast cancer-effects of hypoxia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 29913554	2018
Sulfo-click chemistry with F-labeled thio acids. Chemical communications (Cambridge, England)\| PubMed ID: 30633279	2019
Targeting phosphatidylserine for radionuclide-based molecular imaging of apoptosis. Apoptosis : an international journal on programmed cell death\| PubMed ID: 30684144	2019
Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer. Molecular cancer therapeutics\| PubMed ID: 31548293	2020
Effect of hypoxia on human equilibrative nucleoside transporters hENT1 and hENT2 in breast cancer. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 31601121	2019
Repeated Fractions of X-Radiation to the Breast Fat Pads of Mice Augment Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle. Cancers\| PubMed ID: 31752313	2019
Radiosynthesis and Biological Evaluation of [F]Triacoxib: A New Radiotracer for PET Imaging of COX-2. Molecular pharmaceutics\| PubMed ID: 31816246	2020
Comparison of scandium-44 g with other PET radionuclides in pre-clinical PET phantom imaging. EJNMMI physics\| PubMed ID: 31832809	2019
Radiometal-Containing Aryl Diazonium Salts for Chemoselective Bioconjugation of Tyrosine Residues. ACS omega\| PubMed ID: 31891090	2019