Letian Shan

The First Affiliated Hospital, Zhejiang Chinese Medical University

Affiliated withZhejiang Chinese Medical University

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 28	2020
Publication title Cited by 2	2023

Other Publications

Article	Year
Pharmacokinetics and tissue distribution of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside from traditional Chinese medicine Polygonum multiflorum following oral administration to rats. Journal of ethnopharmacology\| PubMed ID: 21679759	2011
Gene expression profile of steroid-induced necrosis of femoral head of rats. Calcified tissue international\| PubMed ID: 21833848	2011
Pharmacokinetic profile of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside in mice after oral administration of Polygonum multiflorum extract. Drug development and industrial pharmacy\| PubMed ID: 21892876	2012
A PVP-extract fungal protein of Omphalia lapideacens and its antitumor activity on human gastric tumors and normal cells. Oncology reports\| PubMed ID: 21894437	2011
Development and assessment of a complete-detoxication strategy for Fuzi (lateral root of Aconitum carmichaeli) and its application in rheumatoid arthritis therapy. Journal of ethnopharmacology\| PubMed ID: 23376046	2013
Antitumor activity of bacterial exopolysaccharides from the endophyte isolated from . Oncology letters\| PubMed ID: 23833642	2013
Chondroprotective activity of a detoxicated traditional Chinese medicine (Fuzi) of Aconitum carmichaeli Debx against severe-stage osteoarthritis model induced by mono-iodoacetate. Journal of ethnopharmacology\| PubMed ID: 24315981	2014
Plasma metabonomic profiling of lumbar disc herniation and its traditional Chinese medicine subtypes in patients by using gas chromatography coupled with mass spectrometry. Molecular bioSystems\| PubMed ID: 25144444	2014
Evaluation of antioxidant-associated efficacy of flavonoid extracts from a traditional Chinese medicine Hua Ju Hong (peels of Citrus grandis (L.) Osbeck). Journal of ethnopharmacology\| PubMed ID: 25446585	2014
Medicinal effect and its JP2/RyR2-based mechanism of Smilax glabra flavonoids on angiotensin II-induced hypertrophy model of cardiomyocytes. Journal of ethnopharmacology\| PubMed ID: 25926285	2015
In Vivo Cardiotoxicity Induced by Sodium Aescinate in Zebrafish Larvae. Molecules (Basel, Switzerland)\| PubMed ID: 26907249	2016
Biopiracy of natural products and good bioprospecting practice. Phytomedicine : international journal of phytotherapy and phytopharmacology\| PubMed ID: 26926178	2016
Total coumarins of Hedyotis diffusa induces apoptosis of myelodysplastic syndrome SKM-1 cells by activation of caspases and inhibition of PI3K/Akt pathway proteins. Journal of ethnopharmacology\| PubMed ID: 27988397	2017
Anti-Proliferative and Apoptosis-Inducing Effect of Theabrownin against Non-small Cell Lung Adenocarcinoma A549 Cells. Frontiers in pharmacology\| PubMed ID: 27994550	2016
Theabrownin Inhibits Cell Cycle Progression and Tumor Growth of Lung Carcinoma through c-myc-Related Mechanism. Frontiers in pharmacology\| PubMed ID: 28289384	2017
Epimedin C Promotes Vascularization during BMP2-Induced Osteogenesis and Tumor-Associated Angiogenesis. The American journal of Chinese medicine\| PubMed ID: 28659032	2017
Autologous Stem Cells Combined Core Decompression for Treatment of Avascular Necrosis of the Femoral Head: A Systematic Meta-Analysis. BioMed research international\| PubMed ID: 28840126	2017
Theabrownin triggers DNA damage to suppress human osteosarcoma U2OS cells by activating p53 signalling pathway. Journal of cellular and molecular medicine\| PubMed ID: 29993186	2018
Total ginsenosides of Chinese ginseng induces cell cycle arrest and apoptosis in colorectal carcinoma HT-29 cells. Oncology letters\| PubMed ID: 30197678	2018
Evaluation of collagen mixture on promoting skin wound healing in zebrafish caused by acetic acid administration. Biochemical and biophysical research communications\| PubMed ID: 30274782	2018
Agkistrodon ameliorates pain response and prevents cartilage degradation in monosodium iodoacetate-induced osteoarthritic rats by inhibiting chondrocyte hypertrophy and apoptosis. Journal of ethnopharmacology\| PubMed ID: 30529425	2019
Intra-Articular Injection of Extract Attenuates Pain Behavior and Cartilage Degeneration in Mono-Iodoacetate Induced Osteoarthritic Rats. Frontiers in pharmacology\| PubMed ID: 30532708	2018
In vivo acute toxicity of detoxified Fuzi (lateral root of Aconitum carmichaeli) after a traditional detoxification process. EXCLI journal\| PubMed ID: 30564068	2018
[Effect of Huangdi Anxiao Capsules on zebrafish vascular lesions induced by high glucose and high fat]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica\| PubMed ID: 30583635	2018
Chondroprotective effects of platelet lysate towards monoiodoacetate-induced arthritis by suppression of TNF-α-induced activation of NF-ĸB pathway in chondrocytes. Aging\| PubMed ID: 31089001	2019
Hepatoprotective and anti-inflammatory effects of total flavonoids of Qu Zhi Ke (peel of Citrus changshan-huyou) on non-alcoholic fatty liver disease in rats via modulation of NF-κB and MAPK... Phytomedicine : international journal of phytotherapy and phytopharmacology\| PubMed ID: 31541796	2019
Cardiotoxicity and Cardioprotection by Artesunate in Larval Zebrafish. Dose-response : a publication of International Hormesis Society\| PubMed ID: 31975974	2020
Hepatoprotective and Anti-Oxidative Effects of Total Flavonoids From Qu Zhi Qiao (Fruit of Citrus Paradisi cv.Changshanhuyou) on Nonalcoholic Steatohepatitis and Through Nrf2-ARE Signaling... Frontiers in pharmacology\| PubMed ID: 32390839	2020
Inhibition of cell migration and induction of apoptosis by a novel class II histone deacetylase inhibitor, MCC2344. Pharmacological research\| PubMed ID: 32659428	2020
CircAGFG1 drives metastasis and stemness in colorectal cancer by modulating YY1/CTNNB1. Cell death & disease\| PubMed ID: 32681092	2020
Vitamin K chloro derivative (VKT-2) inhibits HDAC6, activates autophagy and apoptosis, and inhibits aggresome formation in hepatocellular carcinoma cells. Biochemical pharmacology\| PubMed ID: 32721508	2020
Evaluation of Long-Time Decoction-Detoxicated (Processed Debeaux Lateral Root With Peel) for Its Acute Toxicity and Therapeutic Effect on Mono-Iodoacetate Induced Osteoarthritis. Frontiers in pharmacology\| PubMed ID: 32848727	2020
Theabrownin Induces Apoptosis and Tumor Inhibition of Hepatocellular Carcinoma Huh7 Cells Through ASK1-JNK-c-Jun Pathway. OncoTargets and therapy\| PubMed ID: 32982289	2020
Theaflavin Induces Apoptosis of A375 Human Melanoma Cells and Inhibits Tumor Growth in Xenograft Zebrafishes Through P53- and JNK-Related Mechanism. Frontiers in pharmacology\| PubMed ID: 32982737	2020
Growth factors-based beneficial effects of platelet lysate on umbilical cord-derived stem cells and their synergistic use in osteoarthritis treatment. Cell death & disease\| PubMed ID: 33057008	2020
Theabrownin inhibits the cytoskeleton‑dependent cell cycle, migration and invasion of human osteosarcoma cells through NF‑κB pathway‑related mechanisms. Oncology reports\| PubMed ID: 33125106	2020
Identification of differentially expressed genes, signaling pathways and immune infiltration in rheumatoid arthritis by integrated bioinformatics analysis. Hereditas\| PubMed ID: 33397492	2021
Anti-Proliferative, Pro-Apoptotic, Anti-Migrative and Tumor-Inhibitory Effects and Pleiotropic Mechanism of Theaflavin on B16F10 Melanoma Cells. OncoTargets and therapy\| PubMed ID: 33658796	2021
Protective effects of total flavonoids from Qu Zhi Qiao (fruit of Citrus paradisi cv. Changshanhuyou) on OVA-induced allergic airway inflammation and remodeling through MAPKs and Smad2/3 sig... Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie\| PubMed ID: 33752061	2021
Selection of safe artemisinin derivatives using a machine learning-based cardiotoxicity platform and in vitro and in vivo validation. Archives of toxicology\| PubMed ID: 34021777	2021
Urine Metabolomics Profiling of Lumbar Disc Herniation and its Traditional Chinese Medicine Subtypes in Patients Through Gas Chromatography Coupled With Mass Spectrometry. Frontiers in molecular biosciences\| PubMed ID: 34179074	2021
A novel moniliformin derivative as pan-inhibitor of histone deacetylases triggering apoptosis of leukemia cells. Biochemical pharmacology\| PubMed ID: 34265280	2021
A Systematic Review and Meta-Analysis of the SuperPATH Approach in Hip Arthroplasty. BioMed research international\| PubMed ID: 34337015	2021
Pain relief and cartilage repair by Nanofat against osteoarthritis: preclinical and clinical evidence. Stem cell research & therapy\| PubMed ID: 34446107	2021
Cytotoxicity of 4-hydroxy-N-(naphthalen-1-yl)-2-oxo-2H-chromene-3-carboxamide in multidrug-resistant cancer cells through activation of PERK/eIF2α/ATF4 pathway. Biochemical pharmacology\| PubMed ID: 34582772	2021
Identification and validation of hub genes of synovial tissue for patients with osteoarthritis and rheumatoid arthritis. Hereditas\| PubMed ID: 34583778	2021
A Novel Mutation of the KLK6 Gene in a Family With Knee Osteoarthritis. Frontiers in genetics\| PubMed ID: 34858488	2021
Green tea-derived theabrownin induces cellular senescence and apoptosis of hepatocellular carcinoma through p53 signaling activation and bypassed JNK signaling suppression. Cancer cell international\| PubMed ID: 35078476	2022
Acute Developmental Toxicity of Panax notoginseng in Zebrafish Larvae. Chinese journal of integrative medicine\| PubMed ID: 35089525	2023
Green tea-derived theabrownin suppresses human non-small cell lung carcinoma in xenograft model through activation of not only p53 signaling but also MAPK/JNK signaling pathway. Journal of ethnopharmacology\| PubMed ID: 35271947	2022
Growth factors-based platelet lysate rejuvenates skin against ageing through NF-κB signalling pathway: In vitro and in vivo mechanistic and clinical studies. Cell proliferation\| PubMed ID: 35274780	2022
Tanshinol suppresses osteosarcoma by specifically inducing apoptosis of U2-OS cells through p53-mediated mechanism. Journal of ethnopharmacology\| PubMed ID: 35331874	2022
Fuzi decoction ameliorates pain and cartilage degeneration of osteoarthritic rats through PI3K-Akt signaling pathway and its clinical retrospective evidence. Phytomedicine : international journal of phytotherapy and phytopharmacology\| PubMed ID: 35378415	2022
Intra-Articular Injection of Adipose-Derived Stem Cells Ameliorates Pain and Cartilage Anabolism/Catabolism in Osteoarthritis: Preclinical and Clinical Evidences. Frontiers in pharmacology\| PubMed ID: 35387326	2022
Human umbilical cord-derived mesenchymal stem cells not only ameliorate blood glucose but also protect vascular endothelium from diabetic damage through a paracrine mechanism mediated by MAP... Stem cell research & therapy\| PubMed ID: 35715841	2022
Onset of p53/NF-κB signaling crosstalk in human melanoma cells in response to anti-cancer theabrownin. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 35779042	2022
Human Umbilical Cord-Derived Mesenchymal Stem Cells Ameliorate Skin Aging of Nude Mice Through Autophagy-Mediated Anti-Senescent Mechanism. Stem cell reviews and reports\| PubMed ID: 35864432	2022
Identification of Gedunin from a Phytochemical Depository as a Novel Multidrug Resistance-Bypassing Tubulin Inhibitor of Cancer Cells. Molecules (Basel, Switzerland)\| PubMed ID: 36144591	2022
Intra-articular injection of placental mesenchymal stromal cells ameliorates pain and cartilage anabolism/catabolism in knee osteoarthritis. Frontiers in pharmacology\| PubMed ID: 36523496	2022
An Innovative Model of ISS-Based Multiple Fractures and Gastrointestinal Dysfunction Related to c-Kit Protein Expression on Interstitial Cells of Cajal. Orthopaedic surgery\| PubMed ID: 36919913	2023
Nanofat lysate ameliorates pain and cartilage degradation of osteoarthritis through activation of TGF-β-Smad2/3 signaling of chondrocytes. Frontiers in pharmacology\| PubMed ID: 37050907	2023