Motoyuki Otsuka

Department of Gastroenterology, The University of Tokyo

Affiliated withThe University of Tokyo the university of tokyo

Research Area

Biography

Motoyuki Otsuka has not added Biography.
If you are Motoyuki Otsuka and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 4	2019

Other Publications

Article	Year
Smad4-independent regulation of p21/WAF1 by transforming growth factor-beta. Oncogene\| PubMed ID: 14762439	2004
Reduced expression of RAS protein activator like-1 in gastric cancer. International journal of cancer\| PubMed ID: 20473946	2011
Direct differentiation of hepatic cells from human induced pluripotent stem cells using a limited number of cytokines. Hepatology international\| PubMed ID: 21484132	2011
MicroRNA122 is a key regulator of α-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma. Nature communications\| PubMed ID: 21654638	2011
Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway. Journal of hepatology\| PubMed ID: 21703185	2011
MicroRNA-22 and microRNA-140 suppress NF-κB activity by regulating the expression of NF-κB coactivators. Biochemical and biophysical research communications\| PubMed ID: 21798241	2011
Receptor for activated protein kinase C: requirement for efficient microRNA function and reduced expression in hepatocellular carcinoma. PloS one\| PubMed ID: 21935400	2011
A miRNA machinery component DDX20 controls NF-κB via microRNA-140 function. Biochemical and biophysical research communications\| PubMed ID: 22445758	2012
MicroRNA-140 acts as a liver tumor suppressor by controlling NF-κB activity by directly targeting DNA methyltransferase 1 (Dnmt1) expression. Hepatology (Baltimore, Md.)\| PubMed ID: 22898998	2013
Silencing of microRNA-122 enhances interferon-α signaling in the liver through regulating SOCS3 promoter methylation. Scientific reports\| PubMed ID: 22957141	2012
A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region. Journal of hepatology\| PubMed ID: 23321320	2013
IL28B minor allele is associated with a younger age of onset of hepatocellular carcinoma in patients with chronic hepatitis C virus infection. Journal of gastroenterology\| PubMed ID: 23689989	2014
Histone demethylase KDM4C regulates sphere formation by mediating the cross talk between Wnt and Notch pathways in colonic cancer cells. Carcinogenesis\| PubMed ID: 23698634	2013
MicroRNAs and liver function. Minerva gastroenterologica e dietologica\| PubMed ID: 23831909	2013
Inhibition of microRNA122 decreases SREBP1 expression by modulating suppressor of cytokine signaling 3 expression. Biochemical and biophysical research communications\| PubMed ID: 23891753	2013
The flavonoid apigenin improves glucose tolerance through inhibition of microRNA maturation in miRNA103 transgenic mice. Scientific reports\| PubMed ID: 23989853	2013
Unique haploinsufficient role of the microRNA-processing molecule Dicer1 in a murine colitis-associated tumorigenesis model. PloS one\| PubMed ID: 24023722	2013
Regulation of the expression of the liver cancer susceptibility gene MICA by microRNAs. Scientific reports\| PubMed ID: 24061441	2013
Impact of PNPLA3 polymorphisms on the development of hepatocellular carcinoma in patients with chronic hepatitis C virus infection. Hepatology research : the official journal of the Japan Society of Hepatology\| PubMed ID: 24125181	2014
The role of microRNAs in hepatocarcinogenesis: current knowledge and future prospects. Journal of gastroenterology\| PubMed ID: 24258409	2014
Specific delivery of microRNA93 into HBV-replicating hepatocytes downregulates protein expression of liver cancer susceptible gene MICA. Oncotarget\| PubMed ID: 25026299	2014
The flavonoid apigenin inhibits hepatitis C virus replication by decreasing mature microRNA122 levels. Virology\| PubMed ID: 25092460	2014
Diagnostic and therapeutic application of noncoding RNAs for hepatocellular carcinoma. World journal of hepatology\| PubMed ID: 25624991	2015
Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine. Oncotarget\| PubMed ID: 25826076	2015
Current status of miRNA-targeting therapeutics and preclinical studies against gastroenterological carcinoma. Molecular and cellular therapies\| PubMed ID: 26056570	2013
Novel therapeutic approaches for hepatitis B virus covalently closed circular DNA. World journal of gastroenterology\| PubMed ID: 26109795	2015
ROCK inhibition enhances microRNA function by promoting deadenylation of targeted mRNAs via increasing PAIP2 expression. Nucleic acids research\| PubMed ID: 26187994	2015
Transdifferentiation of human fibroblasts into hepatocyte-like cells by defined transcriptional factors. Hepatology international\| PubMed ID: 26201932	2013
Circulating RNAs as new biomarkers for detecting pancreatic cancer. World journal of gastroenterology\| PubMed ID: 26229396	2015
Development of a screening method to identify regulators of MICA shedding. Biochemical and biophysical research communications\| PubMed ID: 26299929	2015
Mutual antagonism between hepatitis B viral mRNA and host microRNA let-7. Scientific reports\| PubMed ID: 26979389	2016
MicroRNAs and liver disease. Journal of human genetics\| PubMed ID: 27225852	2017
Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1. Nature communications\| PubMed ID: 27667193	2016
Quantitation of circulating satellite RNAs in pancreatic cancer patients. JCI insight\| PubMed ID: 27699267	2016
Repression of MicroRNA Function Mediates Inflammation-associated Colon Tumorigenesis. Gastroenterology\| PubMed ID: 27825961	2017
Transcriptional activation of the MICA gene with an engineered CRISPR-Cas9 system. Biochemical and biophysical research communications\| PubMed ID: 28322797	2017
Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28439013	2017
RASAL1 is a potent regulator of hepatic stellate cell activity and liver fibrosis. Oncotarget\| PubMed ID: 29029395	2017
CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity. Gut\| PubMed ID: 29437870	2018
Satellite RNA Increases DNA Damage and Accelerates Tumor Formation in Mouse Models of Pancreatic Cancer. Molecular cancer research : MCR\| PubMed ID: 29748382	2018
DHX9 regulates production of hepatitis B virus-derived circular RNA and viral protein levels. Oncotarget\| PubMed ID: 29765512	2018
Hepatitis B virus pathogenesis: Fresh insights into hepatitis B virus RNA. World journal of gastroenterology\| PubMed ID: 29881235	2018
Liver stiffness measurements in chronic hepatitis C: Treatment evaluation and risk assessment. Journal of gastroenterology and hepatology\| PubMed ID: 30393960	2019
ISGF3 with reduced phosphorylation is associated with constitutive expression of interferon-induced genes in aging cells. NPJ aging and mechanisms of disease\| PubMed ID: 30455980	2018
Inflammation and de-differentiation in pancreatic carcinogenesis. World journal of clinical cases\| PubMed ID: 30568942	2018
Pevonedistat, a Neuronal Precursor Cell-Expressed Developmentally Down-Regulated Protein 8-Activating Enzyme Inhibitor, Is a Potent Inhibitor of Hepatitis B Virus. Hepatology (Baltimore, Md.)\| PubMed ID: 30586159	2019
Inhibition of HBV Transcription From cccDNA With Nitazoxanide by Targeting the HBx-DDB1 Interaction. Cellular and molecular gastroenterology and hepatology\| PubMed ID: 30704981	2019
Expression of circular RNA CDR1‑AS in colon cancer cells increases cell surface PD‑L1 protein levels. Oncology reports\| PubMed ID: 31322270	2019
Detection of circulating colorectal cancer cells by a custom microfluid system before and after endoscopic metallic stent placement. Oncology letters\| PubMed ID: 31807163	2019