Craig R. Roy

Department of Microbial Pathogenesis, Yale University School of Medicine

Affiliated withYale University School of Medicine

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 5	2020

Other Publications

Article	Year
Identification and subcellular localization of the Legionella pneumophila IcmX protein: a factor essential for establishment of a replicative organelle in eukaryotic host cells. Infection and immunity\| PubMed ID: 10858211	2000
The DotA protein from Legionella pneumophila is secreted by a novel process that requires the Dot/Icm transporter. The EMBO journal\| PubMed ID: 11689436	2001
A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes. Science (New York, N.Y.)\| PubMed ID: 11809974	2002
The Dot/lcm transporter of Legionella pneumophila: a bacterial conductor of vesicle trafficking that orchestrates the establishment of a replicative organelle in eukaryotic hosts. International journal of medical microbiology : IJMM\| PubMed ID: 11890545	2002
The road less traveled: transport of Legionella to the endoplasmic reticulum. The Journal of cell biology\| PubMed ID: 12147677	2002
Exploitation of the endoplasmic reticulum by bacterial pathogens. Trends in microbiology\| PubMed ID: 12217507	2002
Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites. Nature cell biology\| PubMed ID: 12447391	2002
Eukaryotic cells and microbial pathogens: a familiar couple take centre stage. Nature cell biology\| PubMed ID: 12511887	2003
Show me the substrates: modulation of host cell function by type IV secretion systems. Cellular microbiology\| PubMed ID: 12780775	2003
Legionella reveal dendritic cell functions that facilitate selection of antigens for MHC class II presentation. Immunity\| PubMed ID: 12818162	2003
Legionella subvert the functions of Rab1 and Sec22b to create a replicative organelle. The Journal of experimental medicine\| PubMed ID: 15117975	2004
Immunity to vacuolar pathogens: what can we learn from Legionella? Cellular microbiology\| PubMed ID: 15469430	2004
Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection. The Journal of biological chemistry\| PubMed ID: 15485838	2004
A C-terminal translocation signal required for Dot/Icm-dependent delivery of the Legionella RalF protein to host cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15613486	2005
The Legionella IcmS-IcmW protein complex is important for Dot/Icm-mediated protein translocation. Molecular microbiology\| PubMed ID: 15661013	2005
Bacterial subversion of the host secretory pathway. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15677328	2005
Processing and major histocompatibility complex class II presentation of Legionella pneumophila antigens by infected macrophages. Infection and immunity\| PubMed ID: 15784579	2005
A yeast genetic system for the identification and characterization of substrate proteins transferred into host cells by the Legionella pneumophila Dot/Icm system. Molecular microbiology\| PubMed ID: 15853880	2005
Effect of vitrector cutting rate on vitreous biopsy yield. Retina (Philadelphia, Pa.)\| PubMed ID: 16141874	2005
Activated macrophages infected with Legionella inhibit T cells by means of MyD88-dependent production of prostaglandins. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16339557	2005
The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection. Nature immunology\| PubMed ID: 16444259	2006
Pathogen-endoplasmic-reticulum interactions: in through the out door. Nature reviews. Immunology\| PubMed ID: 16491138	2006
Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity. PLoS pathogens\| PubMed ID: 16552444	2006
Attachment and fusion of endoplasmic reticulum with vacuoles containing Legionella pneumophila. Cellular microbiology\| PubMed ID: 16611228	2006
MyD88-dependent responses involving toll-like receptor 2 are important for protection and clearance of Legionella pneumophila in a mouse model of Legionnaires' disease. Infection and immunity\| PubMed ID: 16714560	2006
Recognition and delivery of effector proteins into eukaryotic cells by bacterial secretion systems. Traffic (Copenhagen, Denmark)\| PubMed ID: 16734660	2006
The Legionella pneumophila effector protein DrrA is a Rab1 guanine nucleotide-exchange factor. Nature cell biology\| PubMed ID: 16906144	2006
NALP3: a key player in caspase-1 activation. Journal of endotoxin research\| PubMed ID: 16953978	2006
Effector proteins translocated by Legionella pneumophila: strength in numbers. Trends in microbiology\| PubMed ID: 17632005	2007
Coxiella burnetii inhibits activation of host cell apoptosis through a mechanism that involves preventing cytochrome c release from mitochondria. Infection and immunity\| PubMed ID: 17709406	2007
Pathogen subversion of cell-intrinsic innate immunity. Nature immunology\| PubMed ID: 17952043	2007
Legionella pneumophila proteins that regulate Rab1 membrane cycling. Nature\| PubMed ID: 17952054	2007
The Legionella pneumophila IcmSW complex interacts with multiple Dot/Icm effectors to facilitate type IV translocation. PLoS pathogens\| PubMed ID: 18069892	2007
Host cell processes that influence the intracellular survival of Legionella pneumophila. Cellular microbiology\| PubMed ID: 18363881	2008
Analyzing association of the endoplasmic reticulum with the legionella pneumophila-containing vacuoles by fluorescence microscopy. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 18425463	2008
Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors. Science (New York, N.Y.)\| PubMed ID: 18566289	2008
Multiple MyD88-dependent responses contribute to pulmonary clearance of Legionella pneumophila. Cellular microbiology\| PubMed ID: 18782351	2009
Modulation of ubiquitin dynamics and suppression of DALIS formation by the Legionella pneumophila Dot/Icm system. Cellular microbiology\| PubMed ID: 19016782	2009
Type IV secretion-dependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella pneumophila. PLoS pathogens\| PubMed ID: 19043549	2008
A Legionella pneumophila effector protein encoded in a region of genomic plasticity binds to Dot/Icm-modified vacuoles. PLoS pathogens\| PubMed ID: 19165328	2009
Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila. Infection and immunity\| PubMed ID: 19237518	2009
Bacterial FIC Proteins AMP Up Infection. Science signaling\| PubMed ID: 19293428	2009
Structure and function of interacting IcmR-IcmQ domains from a type IVb secretion system in Legionella pneumophila. Structure (London, England : 1993)\| PubMed ID: 19368892	2009
Rapid pathogen-induced apoptosis: a mechanism used by dendritic cells to limit intracellular replication of Legionella pneumophila. PLoS pathogens\| PubMed ID: 19521510	2009
Legionella pneumophila promotes functional interactions between plasma membrane syntaxins and Sec22b. Traffic (Copenhagen, Denmark)\| PubMed ID: 20163564	2010
The Anaplasma phagocytophilum-occupied vacuole selectively recruits Rab-GTPases that are predominantly associated with recycling endosomes. Cellular microbiology\| PubMed ID: 20345488	2010
Cooperation between multiple microbial pattern recognition systems is important for host protection against the intracellular pathogen Legionella pneumophila. Infection and immunity\| PubMed ID: 20351139	2010
Manipulation of host membrane machinery by bacterial pathogens. Current opinion in cell biology\| PubMed ID: 20542678	2010
Lipidation by the host prenyltransferase machinery facilitates membrane localization of Legionella pneumophila effector proteins. The Journal of biological chemistry\| PubMed ID: 20813839	2010
Inhibition of pathogen-induced apoptosis by a Coxiella burnetii type IV effector protein. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20944063	2010
The Coxiella burnetii Dot/Icm system delivers a unique repertoire of type IV effectors into host cells and is required for intracellular replication. PLoS pathogens\| PubMed ID: 21637816	2011
Asc modulates the function of NLRC4 in response to infection of macrophages by Legionella pneumophila. mBio\| PubMed ID: 21771913	2011
Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice. Cellular microbiology\| PubMed ID: 21790939	2011
Modulation of Rab GTPase function by a protein phosphocholine transferase. Nature\| PubMed ID: 21822290	2011
The Coxiella burnetii Dot/Icm system creates a comfortable home through lysosomal renovation. mBio\| PubMed ID: 22010216	2011
Subversion of membrane transport pathways by vacuolar pathogens. The Journal of cell biology\| PubMed ID: 22123831	2011
The Legionella pneumophila effector DrrA is sufficient to stimulate SNARE-dependent membrane fusion. Cell host & microbe\| PubMed ID: 22264512	2012
Vacuolar pathogens value membrane integrity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22343287	2012
Coxiella burnetii secretion systems. Advances in experimental medicine and biology\| PubMed ID: 22711632	2012
The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation. Science (New York, N.Y.)\| PubMed ID: 23112293	2012
Analyzing caspase-1 activation during Legionella pneumophila infection in macrophages. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 23150415	2013
The capping domain in RalF regulates effector functions. PLoS pathogens\| PubMed ID: 23166491	2012
The role of Rab GTPases in the transport of vacuoles containing Legionella pneumophila and Coxiella burnetii. Biochemical Society transactions\| PubMed ID: 23176480	2012
Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23307811	2013
Effector protein translocation by the Coxiella burnetii Dot/Icm type IV secretion system requires endocytic maturation of the pathogen-occupied vacuole. PloS one\| PubMed ID: 23349930	2013
Host pathways important for Coxiella burnetii infection revealed by genome-wide RNA interference screening. mBio\| PubMed ID: 23362322	2013
Structure of the Legionella effector AnkX reveals the mechanism of phosphocholine transfer by the FIC domain. The EMBO journal\| PubMed ID: 23572077	2013
The Legionella pneumophila GTPase activating protein LepB accelerates Rab1 deactivation by a non-canonical hydrolytic mechanism. The Journal of biological chemistry\| PubMed ID: 23821544	2013
Identification and functional characterization of K(+) transporters encoded by Legionella pneumophila kup genes. Cellular microbiology\| PubMed ID: 23848378	2013
Autophagy and bacterial infection: an evolving arms race. Trends in microbiology\| PubMed ID: 23880062	2013
A Rab-centric perspective of bacterial pathogen-occupied vacuoles. Cell host & microbe\| PubMed ID: 24034612	2013
Pathogen signatures activate a ubiquitination pathway that modulates the function of the metabolic checkpoint kinase mTOR. Nature immunology\| PubMed ID: 24121838	2013
A novel membrane sensor controls the localization and ArfGEF activity of bacterial RalF. PLoS pathogens\| PubMed ID: 24244168	2013
Legionella pneumophila subversion of host vesicular transport by SidC effector proteins. Traffic (Copenhagen, Denmark)\| PubMed ID: 24483784	2014
AMPylation is critical for Rab1 localization to vacuoles containing Legionella pneumophila. mBio\| PubMed ID: 24520063	2014
Structural basis for PI(4)P-specific membrane recruitment of the Legionella pneumophila effector DrrA/SidM. Structure (London, England : 1993)\| PubMed ID: 24530282	2014
The machinery at endoplasmic reticulum-plasma membrane contact sites contributes to spatial regulation of multiple Legionella effector proteins. PLoS pathogens\| PubMed ID: 24992562	2014
A screen of Coxiella burnetii mutants reveals important roles for Dot/Icm effectors and host autophagy in vacuole biogenesis. PLoS pathogens\| PubMed ID: 25080348	2014
Alveolar macrophages and neutrophils are the primary reservoirs for Legionella pneumophila and mediate cytosolic surveillance of type IV secretion. Infection and immunity\| PubMed ID: 25092908	2014
On the use of Legionella/Rickettsia chimeras to investigate the structure and regulation of Rickettsia effector RalF. Journal of structural biology\| PubMed ID: 25498244	2015
Toxicity and SidJ-Mediated Suppression of Toxicity Require Distinct Regions in the SidE Family of Legionella pneumophila Effectors. Infection and immunity\| PubMed ID: 26099583	2015
Structure and function of Fic proteins. Nature reviews. Microbiology\| PubMed ID: 26299785	2015
Biogenesis of the lysosome-derived vacuole containing Coxiella burnetii. Microbes and infection\| PubMed ID: 26327296	2015
The Legionella Anti-autophagy Effector RavZ Targets the Autophagosome via PI3P- and Curvature-Sensing Motifs. Developmental cell\| PubMed ID: 26343456	2015
Inhibition of inflammasome activation by Coxiella burnetii type IV secretion system effector IcaA. Nature communications\| PubMed ID: 26687278	2015
Primary Role for Toll-Like Receptor-Driven Tumor Necrosis Factor Rather than Cytosolic Immune Detection in Restricting Coxiella burnetii Phase II Replication within Mouse Macrophages. Infection and immunity\| PubMed ID: 26787725	2016
Chitinase 3-Like 1 (Chil1) Regulates Survival and Macrophage-Mediated Interleukin-1β and Tumor Necrosis Factor Alpha during Pseudomonas aeruginosa Pneumonia. Infection and immunity\| PubMed ID: 27141083	2016
Effector Protein Cig2 Decreases Host Tolerance of Infection by Directing Constitutive Fusion of Autophagosomes with the Coxiella-Containing Vacuole. mBio\| PubMed ID: 27435465	2016
Legionella pneumophila Type IV Effectors YlfA and YlfB Are SNARE-Like Proteins that Form Homo- and Heteromeric Complexes and Enhance the Efficiency of Vacuole Remodeling. PloS one\| PubMed ID: 27459495	2016
Erratum for Kohler et al., Effector Protein Cig2 Decreases Host Tolerance of Infection by Directing Constitutive Fusion of Autophagosomes with the Coxiella-Containing Vacuole. mBio\| PubMed ID: 27601576	2016
Autophagy Evasion and Endoplasmic Reticulum Subversion: The Yin and Yang of Legionella Intracellular Infection. Annual review of microbiology\| PubMed ID: 27607556	2016
MTOR-Driven Metabolic Reprogramming Regulates Legionella pneumophila Intracellular Niche Homeostasis. PLoS pathogens\| PubMed ID: 27942021	2016
Autophagic targeting and avoidance in intracellular bacterial infections. Current opinion in microbiology\| PubMed ID: 27984783	2017
A Farnesylated Coxiella burnetii Effector Forms a Multimeric Complex at the Mitochondrial Outer Membrane during Infection. Infection and immunity\| PubMed ID: 28242621	2017
DNA Delivery and Genomic Integration into Mammalian Target Cells through Type IV A and B Secretion Systems of Human Pathogens. Frontiers in microbiology\| PubMed ID: 28878740	2017
Multiple effector virulence phenotypes revealed through high-throughput analysis of targeted mutant libraries. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29133401	2017
Dot/Icm-Translocated Proteins Important for Biogenesis of the Coxiella burnetii-Containing Vacuole Identified by Screening of an Effector Mutant Sublibrary. Infection and immunity\| PubMed ID: 29339460	2018
Subversion of Host Membrane Dynamics by the Legionella Dot/Icm Type IV Secretion System. Current topics in microbiology and immunology\| PubMed ID: 29536361	2017
A unique cytoplasmic ATPase complex defines the Legionella pneumophila type IV secretion channel. Nature microbiology\| PubMed ID: 29784975	2018
remodels the plasma membrane-derived vacuole by utilizing exocyst components as tethers. The Journal of cell biology\| PubMed ID: 30275106	2018
Host cell depletion of tryptophan by IFNγ-induced Indoleamine 2,3-dioxygenase 1 (IDO1) inhibits lysosomal replication of Coxiella burnetii. PLoS pathogens\| PubMed ID: 31461509	2019
Screening effectors for antiviral effects reveals Rab1 GTPase as a proviral factor coopted for tombusvirus replication. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 31591191	2019
Biogenesis of the Spacious -Containing Vacuole Depends on Host Transcription Factors TFEB and TFE3. Infection and immunity\| PubMed ID: 31818957	2020
Analysis of Dot/Icm Type IVB Secretion System Subassemblies by Cryoelectron Tomography Reveals Conformational Changes Induced by DotB Binding. mBio\| PubMed ID: 32071271	2020