Owen P. McGuinness

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine

Affiliated withVanderbilt University School of Medicine

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 150	2011

Other Publications

Article	Year
Physiological consequences of phasic insulin release in the normal animal. Diabetes\| PubMed ID: 11815467	2002
Impact of intraportal N(omega)-nitro-L-arginine infusion on hepatic glucose metabolism in total parenteral nutrition-adapted dogs: interaction with infection. Metabolism: clinical and experimental\| PubMed ID: 11887160	2002
Impact of chronic fructose infusion on hepatic metabolism during TPN administration. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 12424103	2002
Infection impairs insulin-dependent hepatic glucose uptake during total parenteral nutrition. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 12441309	2003
Effects of fructose on hepatic glucose metabolism. Current opinion in clinical nutrition and metabolic care\| PubMed ID: 12806219	2003
Impact of infection on glucose-dependent liver glucose uptake during TPN: interaction with insulin. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 14532169	2004
Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1. Diabetes\| PubMed ID: 14747283	2004
Microfluidic glucose stimulation reveals limited coordination of intracellular Ca2+ activity oscillations in pancreatic islets. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15317941	2004
Time course of the hepatic adaptation to TPN: interaction with glycogen depletion. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 15339746	2005
Control of muscle glucose uptake: test of the rate-limiting step paradigm in conscious, unrestrained mice. The Journal of physiology\| PubMed ID: 15576451	2005
Impact of continuous and pulsatile insulin delivery on net hepatic glucose uptake. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 15755768	2005
Route-dependent effect of nutritional support on liver glucose uptake. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 15994371	2005
Defective glucose homeostasis during infection. Annual review of nutrition\| PubMed ID: 16011457	2005
Suppression of aging in mice by the hormone Klotho. Science (New York, N.Y.)\| PubMed ID: 16123266	2005
Insulin secretion in the conscious mouse is biphasic and pulsatile. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 16249252	2006
Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 16278247	2006
Individual mice can be distinguished by the period of their islet calcium oscillations: is there an intrinsic islet period that is imprinted in vivo? Diabetes\| PubMed ID: 16306370	2005
Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse. Diabetes\| PubMed ID: 16443772	2006
Glucocorticoid-deficient corticotropin-releasing hormone knockout mice maintain glucose requirements but not autonomic responses during repeated hypoglycemia. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 16449297	2006
Counterregulatory deficits occur within 24 h of a single hypoglycemic episode in conscious, unrestrained, chronically cannulated mice. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 16533951	2006
Impact of portal glucose delivery on glucose metabolism in conscious, unrestrained mice. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 16822956	2006
Deletion of the gene encoding the ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein (UGRP)/glucose-6-phosphatase catalytic subunit-beta results in lowered plasma... The Journal of biological chemistry\| PubMed ID: 17023421	2006
Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 17132826	2007
Glucagon chronically impairs hepatic and muscle glucose disposal. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 17132827	2007
Point-counterpoint: Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 17323468	2007
Macrophage TNF-alpha contributes to insulin resistance and hepatic steatosis in diet-induced obesity. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 17578885	2007
Glucagon-mediated impairments in hepatic and peripheral tissue nutrient disposal are not aggravated by increased lipid availability. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 19208853	2009
Insulin signaling in alpha cells modulates glucagon secretion in vivo. Cell metabolism\| PubMed ID: 19356716	2009
Inactivation of NF-kappaB p50 leads to insulin sensitization in liver through post-translational inhibition of p70S6K. The Journal of biological chemistry\| PubMed ID: 19433583	2009
Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion. The Biochemical journal\| PubMed ID: 19450229	2009
Skeletal muscle AMP-activated protein kinase is essential for the metabolic response to exercise in vivo. The Journal of biological chemistry\| PubMed ID: 19525228	2009
NIH experiment in centralized mouse phenotyping: the Vanderbilt experience and recommendations for evaluating glucose homeostasis in the mouse. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 19638507	2009
Lost in translation. Diabetes\| PubMed ID: 19720822	2009
Metabolic response to endotoxin in vivo in the conscious mouse: role of interleukin-6. Metabolism: clinical and experimental\| PubMed ID: 20102773	2011
Circadian clock gene Bmal1 is not essential; functional replacement with its paralog, Bmal2. Current biology : CB\| PubMed ID: 20153195	2010
Impaired glucose tolerance and predisposition to the fasted state in liver glycogen synthase knock-out mice. The Journal of biological chemistry\| PubMed ID: 20178984	2010
Advantages of dynamic "closed loop" stable isotope flux phenotyping over static "open loop" clamps in detecting silent genetic and dietary phenotypes. Metabolomics : Official journal of the Metabolomic Society\| PubMed ID: 20445758	2010
Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice. Disease models & mechanisms\| PubMed ID: 20713647	2010
Continuous low-dose fructose infusion does not reverse glucagon-mediated decrease in hepatic glucose utilization. Metabolism: clinical and experimental\| PubMed ID: 20940071	2011
Assessment of different bariatric surgeries in the treatment of obesity and insulin resistance in mice. Annals of surgery\| PubMed ID: 21522012	2011
Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues. Aging cell\| PubMed ID: 21895961	2011
Disassociation of Muscle Insulin Signaling and Insulin-Stimulated Glucose Uptake during Endotoxemia. PloS one\| PubMed ID: 22276152	2012
Adropin deficiency is associated with increased adiposity and insulin resistance. Obesity (Silver Spring, Md.)\| PubMed ID: 22318315	2012