Nathan Basisty

Buck Institute for Research on Aging

Affiliated withBuck Institute for Research on Aging National Institutes of Health

Research Area

Biography

Dr. Nathan Basisty is currently an Investigator at the NIA and head of the Translational Geroproteomics Unit (TGU). He received his Ph.D. in Pathology and B.S. in Biochemistry from the University of Washington, where he investigated the role of protein turnover in mammalian aging and longevity using novel combinations of metabolic labeling, LC-MS/MS, and software tools. In 2015, he joined The Buck Institute for Research on Aging, where he did his postdoctoral fellowship in the labs of Dr. Birgit Schilling and Dr. Judith Campisi. There he developed novel and specialized proteomic approaches to understand aging processes and age-related diseases, including the application of data-independent acquisition (DIA) or SWATH workflows to identify and quantify PTMs and secretomes. Dr. Basisty’s awards include two “Aging Cell Best Paper Prizes”, in 2014 and 2017 and the Joseph A. Pignolo, Sr. Award in Aging Research 2016, and the prestigious K99/R00 Pathway to Independence Award in 2020.

JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 9	2020
Publication title Cited by 2	2022

Other Publications

Article	Year
Stable nuclear expression of ATP8 and ATP6 genes rescues a mtDNA Complex V null mutant. Nucleic acids research\| PubMed ID: 27596602	2016
Stable Isotope Labeling Reveals Novel Insights Into Ubiquitin-Mediated Protein Aggregation With Age, Calorie Restriction, and Rapamycin Treatment. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 28958078	2018
Protein Turnover in Aging and Longevity. Proteomics\| PubMed ID: 29453826	2018
Removing 4E-BP Enables Synapses to Refine without Postsynaptic Activity. Cell reports\| PubMed ID: 29617653	2018
Simultaneous Quantification of the Acetylome and Succinylome by 'One-Pot' Affinity Enrichment. Proteomics\| PubMed ID: 30035354	2018
Identifying ubiquitinated proteins and aggregates. Aging\| PubMed ID: 30335616	2018
Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose. PloS one\| PubMed ID: 30586434	2018
Global Lysine Acetylation in Results from Growth Conditions That Favor Acetate Fermentation. Journal of bacteriology\| PubMed ID: 30782634	2019
Post-translational Protein Acetylation: An Elegant Mechanism for Bacteria to Dynamically Regulate Metabolic Functions. Frontiers in microbiology\| PubMed ID: 31354686	2019
Accumulation of "Old Proteins" and the Critical Need for MS-based Protein Turnover Measurements in Aging and Longevity. Proteomics\| PubMed ID: 31408259	2019
Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI. Journal of the American Society of Nephrology : JASN\| PubMed ID: 31575700	2019
A proteomic atlas of senescence-associated secretomes for aging biomarker development. PLoS biology\| PubMed ID: 31945054	2020
Activating transcription factor 4 (ATF4) promotes skeletal muscle atrophy by forming a heterodimer with the transcriptional regulator C/EBPβ. The Journal of biological chemistry\| PubMed ID: 31953319	2020
The power of proteomics to monitor senescence-associated secretory phenotypes and beyond: toward clinical applications. Expert review of proteomics\| PubMed ID: 32425074	2020
Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice. eLife\| PubMed ID: 32648542