a-rabbit-venous-interposition-model-mimicking-revascularization

A Rabbit Venous Interposition Model Mimicking Revascularization Surgery using Vein Grafts to Assess Intimal Hyperplasia under Arterial Blood Pressure

Although vein grafts have been commonly used as autologous grafts in revascularization surgeries for ischemic diseases, the long-term patency remains poor ...

Kyoto University

Takamatsu Red Cross Hospital

Successful Management of Guidewire Kinking in a Patient With Subaortic Septal Bulging Using the Pull-Through Technique During Transapical Transcatheter Aortic Valve Implantation.

A large number of clinical trials of therapeutic angiogenesis in patients with critical limb ischemia have been conducted in recent years. However, limb amputation, which is used as a primary endpoint in such studies, is not often required in Japan, which can make it difficult to carry out related clinical trials. Transcutaneous oxygen pressure (TcPO2) is widely used to evaluate the severity of limb ischemia, to decide the level of amputation, and to predict wound healing after limb amputation. The aim of the present study was to elucidate whether TcPO2 can be a surrogate index of limb ischemia, and to define an appropriate cutoff value for wound healing after limb amputation using meta-analysis.

Transcutaneous oxygen pressure as a surrogate index of lower limb amputation.

MicroRNA-145 (miR-145) reportedly alters the phenotype of vascular smooth muscle cells (VSMCs) from a proliferative to a contractile state. So far, viral or plasmid vectors have been experimentally used to transduce microRNAs into VSMCs. We hypothesized that a simple ex vivo microRNA delivery system using miR-145-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (PLGA NPs) could control the VSMC phenotype and prevent intimal hyperplasia.

Article	Year
Successful Management of Guidewire Kinking in a Patient With Subaortic Septal Bulging Using the Pull-Through Technique During Transapical Transcatheter Aortic Valve Implantation. Circulation journal : official journal of the Japanese Circulation Society\| PubMed ID: 26497331	2016
Transcutaneous oxygen pressure as a surrogate index of lower limb amputation. International angiology : a journal of the International Union of Angiology\| PubMed ID: 26871392	2016
MicroRNA-145-loaded poly(lactic-co-glycolic acid) nanoparticles attenuate venous intimal hyperplasia in a rabbit model. The Journal of thoracic and cardiovascular surgery\| PubMed ID: 30447962	2019

Hiroomi Nishio

Biography

JoVE Journal Publications

Other Publications