Gregory J. Morton

Department of Medicine, University of Washington

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 6	2020

Other Publications

Article	Year
Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats. Endocrinology\| PubMed ID: 12697710	2003
Neuropeptide Y is required for hyperphagic feeding in response to neuroglucopenia. Endocrinology\| PubMed ID: 15064281	2004
Increased hypothalamic melanin concentrating hormone gene expression during energy restriction involves a melanocortin-independent, estrogen-sensitive mechanism. Peptides\| PubMed ID: 15165723	2004
Leptin action in the forebrain regulates the hindbrain response to satiety signals. The Journal of clinical investigation\| PubMed ID: 15711637	2005
Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 16046456	2005
Effects of hypothalamic neurodegeneration on energy balance. PLoS biology\| PubMed ID: 16296893	2005
Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell metabolism\| PubMed ID: 16330326	2005
Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes. Cell metabolism\| PubMed ID: 16399506	2006
Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration. Cell metabolism\| PubMed ID: 17055784	2006
Central interleukin-1 (IL1) signaling is required for pharmacological, but not physiological, effects of leptin on energy balance. Brain research\| PubMed ID: 17320056	2007
Hypothalamic leptin regulation of energy homeostasis and glucose metabolism. The Journal of physiology\| PubMed ID: 17584844	2007
Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis. Endocrinology\| PubMed ID: 18403487	2008
Deficiency of TNFalpha converting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype in mice. Endocrinology\| PubMed ID: 18687778	2008
Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 18772497	2008
Forebrain melanocortin signaling enhances the hindbrain satiety response to CCK-8. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 19109369	2009
Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 19116375	2009
The action of leptin in the ventral tegmental area to decrease food intake is dependent on Jak-2 signaling. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 19435852	2009
Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve. Endocrinology\| PubMed ID: 19574396	2009
Mice lacking hepatic lipase are lean and protected against diet-induced obesity and hepatic steatosis. Endocrinology\| PubMed ID: 20056822	2010
Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats. Diabetes\| PubMed ID: 20357365	2010
Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feeding. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 20371733	2010
Identification of body fat mass as a major determinant of metabolic rate in mice. Diabetes\| PubMed ID: 20413511	2010
Leptin deficiency causes insulin resistance induced by uncontrolled diabetes. Diabetes\| PubMed ID: 20424233	2010
A new oxytocin-saporin cytotoxin for lesioning oxytocin-receptive neurons in the rat hindbrain. Endocrinology\| PubMed ID: 20610562	2010
Assessment of feeding behavior in laboratory mice. Cell metabolism\| PubMed ID: 20620991	2010
Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice. Disease models & mechanisms\| PubMed ID: 20713647	2010
Identification of a physiological role for leptin in the regulation of ambulatory activity and wheel running in mice. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 21062956	2011
Leptin activates a novel CNS mechanism for insulin-independent normalization of severe diabetic hyperglycemia. Endocrinology\| PubMed ID: 21159853	2011
A novel rodent model that mimics the metabolic sequelae of obese craniopharyngioma patients. Pediatric research\| PubMed ID: 21372758	2011
Leptin and the central nervous system control of glucose metabolism. Physiological reviews\| PubMed ID: 21527729	2011
Subcutaneous administration of leptin normalizes fasting plasma glucose in obese type 2 diabetic UCD-T2DM rats. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21873226	2011
Endothelial NO/cGMP/VASP signaling attenuates Kupffer cell activation and hepatic insulin resistance induced by high-fat feeding. Diabetes\| PubMed ID: 21911751	2011
Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 22008455	2012
Obesity is associated with hypothalamic injury in rodents and humans. The Journal of clinical investigation\| PubMed ID: 22201683	2012
Acutely decreased thermoregulatory energy expenditure or decreased activity energy expenditure both acutely reduce food intake in mice. PloS one\| PubMed ID: 22936977	2012
BDNF action in the brain attenuates diabetic hyperglycemia via insulin-independent inhibition of hepatic glucose production. Diabetes\| PubMed ID: 23274899	2013
In uncontrolled diabetes, thyroid hormone and sympathetic activators induce thermogenesis without increasing glucose uptake in brown adipose tissue. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 23384771	2013
Leptin, diabetes, and the brain. Indian journal of endocrinology and metabolism\| PubMed ID: 23565487	2012
Leptin action in the ventromedial hypothalamic nucleus is sufficient, but not necessary, to normalize diabetic hyperglycemia. Endocrinology\| PubMed ID: 23782941	2013
Molecular and functional analysis of human β-defensin 3 action at melanocortin receptors. Chemistry & biology\| PubMed ID: 23790489	2013
FGF19 action in the brain induces insulin-independent glucose lowering. The Journal of clinical investigation\| PubMed ID: 24084738	2013
Is there evidence that estrogen therapy promotes weight maintenance via effects on leptin? Menopause (New York, N.Y.)\| PubMed ID: 24149922	2014
Rapid glutamate release in the mediobasal hypothalamus accompanies feeding and is exaggerated by an obesogenic food. Molecular metabolism\| PubMed ID: 24199157	2013
Cooperation between brain and islet in glucose homeostasis and diabetes. Nature\| PubMed ID: 24201279	2013
Carbohydrate feeding dissociates the postprandial FGF19 response from circulating bile acid levels in humans. The Journal of clinical endocrinology and metabolism\| PubMed ID: 24297792	2014
Neurobiology of food intake in health and disease. Nature reviews. Neuroscience\| PubMed ID: 24840801	2014
Hindbrain oxytocin receptors contribute to the effects of circulating oxytocin on food intake in male rats. Endocrinology\| PubMed ID: 24877632	2014
Genetic determinants of atherosclerosis, obesity, and energy balance in consomic mice. Mammalian genome : official journal of the International Mammalian Genome Society\| PubMed ID: 25001233	2014
Role of melanocortin signaling in neuroendocrine and metabolic actions of leptin in male rats with uncontrolled diabetes. Endocrinology\| PubMed ID: 25137027	2014
Chronic oxytocin administration inhibits food intake, increases energy expenditure, and produces weight loss in fructose-fed obese rhesus monkeys. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 25540103	2015
Evidence That in Uncontrolled Diabetes, Hyperglucagonemia Is Required for Ketosis but Not for Increased Hepatic Glucose Production or Hyperglycemia. Diabetes\| PubMed ID: 25633417	2015
Leptin signaling is required for adaptive changes in food intake, but not energy expenditure, in response to different thermal conditions. PloS one\| PubMed ID: 25756181	2015
In vivo structure-function studies of human hepatic lipase: the catalytic function rescues the lean phenotype of HL-deficient (hl-/-) mice. Physiological reports\| PubMed ID: 25862097	2015
Glucose intolerance induced by blockade of central FGF receptors is linked to an acute stress response. Molecular metabolism\| PubMed ID: 26266088	2015
Evidence against hypothalamic-pituitary-adrenal axis suppression in the antidiabetic action of leptin. The Journal of clinical investigation\| PubMed ID: 26529250	2015
Chronic CNS oxytocin signaling preferentially induces fat loss in high-fat diet-fed rats by enhancing satiety responses and increasing lipid utilization. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 26791828	2016
The role of leptin in diabetes: metabolic effects. Diabetologia\| PubMed ID: 26969486	2016
Functional identification of a neurocircuit regulating blood glucose. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27001850	2016
Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents. Nature medicine\| PubMed ID: 27213816	2016
Physiological role for leptin in the control of thermal conductance. Molecular metabolism\| PubMed ID: 27689002	2016
Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity. Diabetes\| PubMed ID: 28073831	2017
Evidence That the Sympathetic Nervous System Elicits Rapid, Coordinated, and Reciprocal Adjustments of Insulin Secretion and Insulin Sensitivity During Cold Exposure. Diabetes\| PubMed ID: 28115396	2017
Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice. Nature communications\| PubMed ID: 28223698	2017
Metabolically distinct weight loss by 10,12 CLA and caloric restriction highlight the importance of subcutaneous white adipose tissue for glucose homeostasis in mice. PloS one\| PubMed ID: 28245284	2017
Response to . Molecular metabolism\| PubMed ID: 28377869	2017
How Should We Think About the Role of the Brain in Glucose Homeostasis and Diabetes? Diabetes\| PubMed ID: 28603139	2017
Chronic hindbrain administration of oxytocin is sufficient to elicit weight loss in diet-induced obese rats. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 28747407	2017
Androgen receptor deficiency in monocytes/macrophages does not alter adiposity or glucose homeostasis in male mice. Asian journal of andrology\| PubMed ID: 29205180	2018
In Uncontrolled Diabetes, Hyperglucagonemia and Ketosis Result From Deficient Leptin Action in the Parabrachial Nucleus. Endocrinology\| PubMed ID: 29438473	2018
Leptin regulation of core body temperature involves mechanisms independent of the thyroid axis. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 29944392	2018
Distinct Neuronal Projections From the Hypothalamic Ventromedial Nucleus Mediate Glycemic and Behavioral Effects. Diabetes\| PubMed ID: 30257978	2018
Peripheral Mechanisms Mediating the Sustained Antidiabetic Action of FGF1 in the Brain. Diabetes\| PubMed ID: 30523024	2019
Glucoregulatory responses to hypothalamic preoptic area cooling. Brain research\| PubMed ID: 30610874	2019
The Hypothalamic Arcuate Nucleus-Median Eminence Is a Target for Sustained Diabetes Remission Induced by Fibroblast Growth Factor 1. Diabetes\| PubMed ID: 30796029	2019
The central fibroblast growth factor receptor/beta klotho system: Comprehensive mapping in Mus musculus and comparisons to nonhuman primate and human samples using an automated in situ hybri... The Journal of comparative neurology\| PubMed ID: 30809795	2019
The role of vasodilator-stimulated phosphoprotein (VASP) in the control of hepatic gluconeogenic gene expression. PloS one\| PubMed ID: 31017943	2019