Stuart J. Forbes

Scottish Centre for Regenerative Medicine, University of Edinburgh

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 14	2020

Other Publications

Article	Year
Unbiased screening of polymer libraries to define novel substrates for functional hepatocytes with inducible drug metabolism. Stem cell research\| PubMed ID: 21277274	2011
Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. The Journal of clinical investigation\| PubMed ID: 15630444	2005
Progenitor cell characterization and location in the developing human liver. Stem cells and development\| PubMed ID: 17999598	2007
Stem cell therapy for chronic liver disease--choosing the right tools for the job. Gut\| PubMed ID: 18192451	2008
Regulation of alternative macrophage activation by galectin-3. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18250477	2008
The inhibitory role of stromal cell mesenchyme on human embryonic stem cell hepatocyte differentiation is overcome by Wnt3a treatment. Cloning and stem cells\| PubMed ID: 18479212	2008
Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18719101	2008
The isolation and in vitro expansion of hepatic Sca-1 progenitor cells. Biochemical and biophysical research communications\| PubMed ID: 19233130	2009
Side population cells in developing human liver are primarily haematopoietic progenitor cells. Experimental cell research\| PubMed ID: 19233167	2009
A fat chance for hepatocyte transplantation? Gut\| PubMed ID: 19299381	2009
Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology (Baltimore, Md.)\| PubMed ID: 19877180	2010
Practical barriers to delivering autologous bone marrow stem cell therapy as an adjunct to liver resection. Stem cells and development\| PubMed ID: 19954303	2010
Liver development, regeneration, and carcinogenesis. Journal of biomedicine & biotechnology\| PubMed ID: 20169172	2010
Portal venous endothelium in developing human liver contains haematopoietic and epithelial progenitor cells. Experimental cell research\| PubMed ID: 20211168	2010
Characterisation of a stereotypical cellular and extracellular adult liver progenitor cell niche in rodents and diseased human liver. Gut\| PubMed ID: 20427399	2010
Prospects for stem cell transplantation in the treatment of hepatic disease. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society\| PubMed ID: 20583084	2010
Persistence of functional hepatocyte-like cells in immune-compromised mice. Liver international : official journal of the International Association for the Study of the Liver\| PubMed ID: 21143581	2011
Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function. Hepatology (Baltimore, Md.)\| PubMed ID: 21433043	2011
Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells. Hepatology (Baltimore, Md.)\| PubMed ID: 21442631	2011
Liver fibrogenic cells. Best practice & research. Clinical gastroenterology\| PubMed ID: 21497739	2011
Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis. American journal of respiratory and critical care medicine\| PubMed ID: 21680953	2011
Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3. American journal of respiratory and critical care medicine\| PubMed ID: 22095546	2012
Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis. Hepatology (Baltimore, Md.)\| PubMed ID: 22223197	2012
Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. Nature medicine\| PubMed ID: 22388089	2012
Liver sinusoidal endothelial cells in disease--and for therapy? Journal of hepatology\| PubMed ID: 22892397	2013
Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23100531	2012
Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23576749	2013
Suppression of Epithelial to Mesenchymal Transitioning (EMT) Enhances Ex Vivo Reprogramming of Human Exocrine Pancreatic Tissue towards Functional Insulin Producing Î²-Like Cells. Diabetes\| PubMed ID: 23610058	2013
Differentiation of progenitors in the liver: a matter of local choice. The Journal of clinical investigation\| PubMed ID: 23635784	2013
Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertension in vivo. Hepatology (Baltimore, Md.)\| PubMed ID: 23873655	2014
Cell lineage tracing reveals a biliary origin of intrahepatic cholangiocarcinoma. Cancer research\| PubMed ID: 24310400	2014
Links between hepatic fibrosis, ductular reaction, and progenitor cell expansion. Gastroenterology\| PubMed ID: 24315991	2014
CD133+ cancer stem-like cells in small cell lung cancer are highly tumorigenic and chemoresistant but sensitive to a novel neuropeptide antagonist. Cancer research\| PubMed ID: 24436149	2014
Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages. PloS one\| PubMed ID: 24475094	2014
Polysialic acid/neural cell adhesion molecule modulates the formation of ductular reactions in liver injury. Hepatology (Baltimore, Md.)\| PubMed ID: 24585441	2014
Markedly Increased High-Mobility Group Box 1 Protein in a Patient with Small-for-Size Syndrome. Case reports in transplantation\| PubMed ID: 24600525	2014
Galectin-3 regulates hepatic progenitor cell expansion during liver injury. Gut\| PubMed ID: 24837171	2014
Preparing the ground for tissue regeneration: from mechanism to therapy. Nature medicine\| PubMed ID: 25100531	2014
Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma. Journal of hepatology\| PubMed ID: 25450711	2015
Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance. Advanced healthcare materials\| PubMed ID: 26109270	2015
Organoid cultures boost human liver cell expansion. Hepatology (Baltimore, Md.)\| PubMed ID: 26146934	2015
Hepatic progenitor cells of biliary origin with liver repopulation capacity. Nature cell biology\| PubMed ID: 26192438	2015
Polyurethane: Stable Cell Phenotype Requires Plasticity: Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance (Adv. Healthcare ... Advanced healthcare materials\| PubMed ID: 26308957	2015
Phenotypic and functional characterization of macrophages with therapeutic potential generated from human cirrhotic monocytes in a cohort study. Cytotherapy\| PubMed ID: 26342993	2015
CSF1 Restores Innate Immunity After Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure. Gastroenterology\| PubMed ID: 26344055	2015
Two Fresh Streams to Fill the Liver's Hepatocyte Pool. Cell stem cell\| PubMed ID: 26431179	2015
Krüppel-Like Factor 4 Overexpression Initiates a Mesenchymal-to-Epithelial Transition and Redifferentiation of Human Pancreatic Cells following Expansion in Long Term Adherent Culture. PloS one\| PubMed ID: 26457418	2015
Recombinant Laminins Drive the Differentiation and Self-Organization of hESC-Derived Hepatocytes. Stem cell reports\| PubMed ID: 26626180	2015
Vasopressin Regulates Extracellular Vesicle Uptake by Kidney Collecting Duct Cells. Journal of the American Society of Nephrology : JASN\| PubMed ID: 27020854	2016
Reducing Hepatocyte Injury and Necrosis in Response to Paracetamol Using Noncoding RNAs. Stem cells translational medicine\| PubMed ID: 27057006	2016
The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size. Nature cell biology\| PubMed ID: 27088858	2016
Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA). Nature reviews. Gastroenterology & hepatology\| PubMed ID: 27095655	2016
Corrigendum to "Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma" [J Hepatol 2015;62:607-616]. Journal of hepatology\| PubMed ID: 27198050	2016
Liver regeneration - mechanisms and models to clinical application. Nature reviews. Gastroenterology & hepatology\| PubMed ID: 27353402	2016
Interleukin-13 Activates Distinct Cellular Pathways Leading to Ductular Reaction, Steatosis, and Fibrosis. Immunity\| PubMed ID: 27421703	2016
Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers. Gut\| PubMed ID: 27618837	2017
Notch3 drives development and progression of cholangiocarcinoma. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27791012	2016
Advances in cholangiocarcinoma research: report from the third Cholangiocarcinoma Foundation Annual Conference. Journal of gastrointestinal oncology\| PubMed ID: 28078106	2016
Functionalized superparamagnetic iron oxide nanoparticles provide highly efficient iron-labeling in macrophages for magnetic resonance-based detection in vivo. Cytotherapy\| PubMed ID: 28214127	2017
Milk Fat Globule-EGF Factor 8 for Liver Fibrosis Therapy: Creaming Off the Beneficial Effects of Mesenchymal Stromal Cells. Gastroenterology\| PubMed ID: 28259796	2017
Development, functional characterization and validation of methodology for GMP-compliant manufacture of phagocytic macrophages: A novel cellular therapeutic for liver cirrhosis. Cytotherapy\| PubMed ID: 28673774	2017
Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration. Nature\| PubMed ID: 28700576	2017
11Beta-hydroxysteroid dehydrogenase-1 deficiency or inhibition enhances hepatic myofibroblast activation in murine liver fibrosis. Hepatology (Baltimore, Md.)\| PubMed ID: 29251794	2018
The STAT3-IL-10-IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 29263216	2018
GADD45β Loss Ablates Innate Immunosuppression in Cancer. Cancer research\| PubMed ID: 29279355	2018
Raman spectroscopy and regenerative medicine: a review. NPJ Regenerative medicine\| PubMed ID: 29302348	2017
Studies of macrophage therapy for cirrhosis - From mice to men. Journal of hepatology\| PubMed ID: 29317297	2018
Paracrine cellular senescence exacerbates biliary injury and impairs regeneration. Nature communications\| PubMed ID: 29523787	2018
TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence. Science translational medicine\| PubMed ID: 30111642	2018
3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo. Archives of toxicology\| PubMed ID: 30155720	2018
Hepatocyte-Specific β-Catenin Deletion During Severe Liver Injury Provokes Cholangiocytes to Differentiate Into Hepatocytes. Hepatology (Baltimore, Md.)\| PubMed ID: 30215850	2019
Telomerase Activity Links to Regenerative Capacity of Hepatocytes. Transplantation\| PubMed ID: 30247437	2018
Cellular Plasticity in Liver Regeneration: Spotlight on Cholangiocytes. Hepatology (Baltimore, Md.)\| PubMed ID: 30382597	2019
Mesenchymal Stem Cells and Induced Bone Marrow-Derived Macrophages Synergistically Improve Liver Fibrosis in Mice. Stem cells translational medicine\| PubMed ID: 30394698	2019
An Orally Active Galectin-3 Antagonist Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade. Cancer research\| PubMed ID: 30674531	2019
Quantifying changes in innate immune function following liver transplantation for chronic liver disease. HPB : the official journal of the International Hepato Pancreato Biliary Association\| PubMed ID: 30850189	2019
Beneficial Noncancerous Mutations in Liver Disease. Trends in genetics : TIG\| PubMed ID: 31151757	2019
Macrophages as a Cell-Based Therapy for Liver Disease. Seminars in liver disease\| PubMed ID: 31242527	2019
Peribiliary Gland Niche Participates in Biliary Tree Regeneration in Mouse and in Human Primary Sclerosing Cholangitis. Hepatology (Baltimore, Md.)\| PubMed ID: 31330051	2020
Safety profile of autologous macrophage therapy for liver cirrhosis. Nature medicine\| PubMed ID: 31591593	2019
Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration. Nature cell biology\| PubMed ID: 31685987	2019
Modulation of biliary cancer chemo-resistance through microRNA-mediated rewiring of the expansion of CD133+ cells. Hepatology (Baltimore, Md.)\| PubMed ID: 31879968	2019
Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 31915293	2020
Regional differences in human biliary tissues and corresponding in vitro derived organoids. Hepatology (Baltimore, Md.)\| PubMed ID: 32222998	2020
Absolute measurement of the tissue origins of cell-free DNA in the healthy state and following paracetamol overdose. BMC medical genomics\| PubMed ID: 32252771	2020
TFEB regulates murine liver cell fate during development and regeneration. Nature communications\| PubMed ID: 32424153	2020