generation-of-human-regulatory-t-cell-clones

Generation of Human Regulatory T Cell Clones

Human regulatory T cells (Treg) are notoriously difficult to isolate in high purity given the current methods of Treg enrichment. These methods are based ...

New York University School of Medicine

Clinicians have long assumed that an association exists between crystal arthropathies and the presence of osteoarthritis (OA). However, studies establishing an independent association between calcium pyrophosphate or uric acid crystal disease and OA are sparse. Even less is known about a possible pathogenic relationship. Whereas some studies suggest that the relationships between crystals and OA may not be incidental and that crystal deposition may contribute to the onset and/or acceleration of OA joint damage, other authors have challenged this assertion. In this review, we provide an overview of past and current research elucidating the role of crystal deposition, including monosodium urate, calcium pyrophosphate, and other crystals, in OA. Given the clinical frequency of gout and that agents exist to modulate serum UA levels, special attention is given to the role of monosodium urate crystals.

The role of uric acid and other crystals in osteoarthritis.

The aim of the study is to determine the frequency and functionality of blood conventional dendritic cells (cDCs) in relation to disease activity in systemic lupus erythematosus.

Active systemic lupus erythematosus is associated with decreased blood conventional dendritic cells.

L&#39;&eacute;tude vise &agrave; d&eacute;terminer la fr&eacute;quence et la fonctionnalit&eacute; des cellules dendritiques conventionnelles de sang (cDCs) en ce qui concerne l&#39;activit&eacute; de la maladie dans le lupus &eacute;ryth&eacute;mateux diss&eacute;min&eacute;.

Actif le lupus &eacute;ryth&eacute;mateux diss&eacute;min&eacute; est associ&eacute; &agrave; une diminution des globules dendritiques conventionnelles.

A 40-year-old Chinese man was admitted for haemoptysis and progressive deep vein thrombosis involving the inferior vena cava (IVC) despite anticoagulation. An IVC filter had been placed earlier at an outside hospital. CT angiography revealed two pulmonary artery aneurysms. The patient was found to have a history of oral and genital ulcers, uveitis and erythema nodosum, thus meeting criteria for Behçet's disease. Other causes of the haemoptysis and thrombophilia were excluded. He underwent successful coil embolisation of the pulmonary artery aneurysms and responded well to immunosuppressive therapy with cyclophosphamide and steroids. Anticoagulation was cautiously continued to limit the long-term risk of secondary thrombosis from his IVC filter. The patient remains well 5 months after initiation of immunosuppressive therapy. Making a diagnosis of Behçet's disease in the setting of thrombosis is crucial, as treatment must include immunosuppression, and, thus, fundamentally differs from the management of most other thrombotic disorders. 

Behcet's disease with major vascular involvement.

Apoptotic cell receptors contribute to the induction of tolerance by modulating dendritic cell function following the uptake of apoptotic cells or microparticles. Dendritic cells that have bound or ingested apoptotic cells produce only low amounts of pro-inflammatory cytokines and fail to prime effector T cell responses. Specifically, ligation of the apoptotic cell receptor CR3 (CD11 b/CD18) on human monocyte-derived dendritic cells (moDC) down-modates proinflammatory cytokine secretion, but the consequences for human Th17 cell homeostasis and effector responses remain unknown. Here, we aimed to establish whether CD11b-ligated moDC modulate Th17 cell effector reponses to assess their potential for future use in moDC-based suppressive immunotherapy.

Article	Year
The role of uric acid and other crystals in osteoarthritis. Current rheumatology reports\| PubMed ID: 20425024	2010
Active systemic lupus erythematosus is associated with decreased blood conventional dendritic cells. Experimental and molecular pathology\| PubMed ID: 23773850	2013
Behcet's disease with major vascular involvement. BMJ case reports\| PubMed ID: 24214153	2013
Modulation of human Th17 cell responses through complement receptor 3 (CD11 b/CD18) ligation on monocyte-derived dendritic cells. Journal of autoimmunity\| PubMed ID: 29908907	2018

Johannes Nowatzky

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