intratracheal-instillation-of-stem-cells-in-term-neonatal-rats

Intratracheal Instillation of Stem Cells in Term Neonatal Rats

Prolonged exposure to high concentrations of oxygen leads to inflammation and acute lung injury, which is similar to human bronchopulmonary dysplasia ...

Taipei Medical University

Taipei Medical University Bilingual Education Center

High-resolution microcomputed tomography (micro-CT) is an extremely flexible and accurate technique for three-dimensional examination of biological tissues. The aim was to evaluate the feasibility of micro-CT as a noninvasive tool for analyzing the lung structure during lipopolysaccharide (LPS)-induced acute lung injury (ALI) in rats.

Microcomputed tomography assessment of lipopolysaccharide-induced acute lung injury in rat.

Oxygen therapy is often required to treat newborn infants with respiratory disorders. Prolonged exposure of neonatal rats to hyperoxia reduced alveolar septation, increased terminal air space size, and increased lung fibrosis; these conditions are very similar to those of human bronchopulmonary dysplasia. Epigenetic regulation of gene expression plays a crucial role in bronchopulmonary dysplasia development.

Article	Year
Microcomputed tomography assessment of lipopolysaccharide-induced acute lung injury in rat. Experimental lung research\| PubMed ID: 27070487	2016
Genome-Wide Analysis of DNA Methylation in Hyperoxia-Exposed Newborn Rat Lung. Lung\| PubMed ID: 28689251	2017

Yue-Jun Chen

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