Kathryn E. Saatman

Spinal Cord and Brain Injury Research Center, University of Kentucky

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 12	2020
Publication title	2026

Other Publications

Article	Year
Differential behavioral and histopathological responses to graded cortical impact injury in mice. Journal of neurotrauma\| PubMed ID: 16928182	2006
Classification of traumatic brain injury for targeted therapies. Journal of neurotrauma\| PubMed ID: 18627252	2008
Comparative neuroprotective effects of cyclosporin A and NIM811, a nonimmunosuppressive cyclosporin A analog, following traumatic brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 18714331	2009
Temporal and regional changes in IGF-1/IGF-1R signaling in the mouse brain after traumatic brain injury. Journal of neurotrauma\| PubMed ID: 19751099	2010
Calpain as a therapeutic target in traumatic brain injury. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 20129495	2010
miR-107 regulates granulin/progranulin with implications for traumatic brain injury and neurodegenerative disease. The American journal of pathology\| PubMed ID: 20489155	2010
Targeting individual calpain isoforms for neuroprotection. Experimental neurology\| PubMed ID: 20682310	2010
MicroRNAs in CNS injury: potential roles and therapeutic implications. BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 21053309	2011
Rate of neurodegeneration in the mouse controlled cortical impact model is influenced by impactor tip shape: implications for mechanistic and therapeutic studies. Journal of neurotrauma\| PubMed ID: 21341976	2011
Posttraumatic mossy fiber sprouting is related to the degree of cortical damage in three mouse strains. Epilepsy research\| PubMed ID: 22047981	2012
Genetic manipulation of cell death and neuroplasticity pathways in traumatic brain injury. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 22362424	2012
Calpastatin overexpression limits calpain-mediated proteolysis and behavioral deficits following traumatic brain injury. Experimental neurology\| PubMed ID: 22572592	2012
Rit GTPase signaling promotes immature hippocampal neuronal survival. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22815504	2012
Brain injury-induced proteolysis is reduced in a novel calpastatin-overexpressing transgenic mouse. Journal of neurochemistry\| PubMed ID: 23305291	2013
Calpains mediate axonal cytoskeleton disintegration during Wallerian degeneration. Neurobiology of disease\| PubMed ID: 23542511	2013
Astrocyte-Specific Overexpression of Insulin-Like Growth Factor-1 Protects Hippocampal Neurons and Reduces Behavioral Deficits following Traumatic Brain Injury in Mice. PloS one\| PubMed ID: 23826235	2013
Ablation of matrix metalloproteinase-9 gene decreases cerebrovascular permeability and fibrinogen deposition post traumatic brain injury in mice. Metabolic brain disease\| PubMed ID: 24771110	2015
Conditional overexpression of insulin-like growth factor-1 enhances hippocampal neurogenesis and restores immature neuron dendritic processes after traumatic brain injury. Journal of neuropathology and experimental neurology\| PubMed ID: 25003234	2014
Neuroinflammation and neurologic deficits in diabetes linked to brain accumulation of amylin. Molecular neurodegeneration\| PubMed ID: 25149184	2014
Regional neurodegeneration and gliosis are amplified by mild traumatic brain injury repeated at 24-hour intervals. Journal of neuropathology and experimental neurology\| PubMed ID: 25232942	2014
Phage display for identification of serum biomarkers of traumatic brain injury. Journal of neuroscience methods\| PubMed ID: 27168498	2016
Repeated Closed Head Injury in Mice Results in Sustained Motor and Memory Deficits and Chronic Cellular Changes. PloS one\| PubMed ID: 27427961	2016
IGF-1 mediated Neurogenesis Involves a Novel RIT1/Akt/Sox2 Cascade. Scientific reports\| PubMed ID: 28607354	2017
Brain microvascular injury and white matter disease provoked by diabetes-associated hyperamylinemia. Annals of neurology\| PubMed ID: 28696548	2017
Central Infusion of Insulin-Like Growth Factor-1 Increases Hippocampal Neurogenesis and Improves Neurobehavioral Function after Traumatic Brain Injury. Journal of neurotrauma\| PubMed ID: 29455576	2018
Pre-Clinical Testing of Therapies for Traumatic Brain Injury. Journal of neurotrauma\| PubMed ID: 29756522	2018
Assessment of systemic administration of PEGylated IGF-1 in a mouse model of traumatic brain injury. Restorative neurology and neuroscience\| PubMed ID: 29889090	2018
Doxorubicin-induced elevated oxidative stress and neurochemical alterations in brain and cognitive decline: protection by MESNA and insights into mechanisms of chemotherapy-induced cognitive... Oncotarget\| PubMed ID: 30100992	2018
Experimental Designs for Repeated Mild Traumatic Brain Injury: Challenges and Considerations. Journal of neurotrauma\| PubMed ID: 30351225	2019
Acute Mitochondrial Impairment Underlies Prolonged Cellular Dysfunction after Repeated Mild Traumatic Brain Injuries. Journal of neurotrauma\| PubMed ID: 30417732	2019
Noninvasive noncontact speckle contrast diffuse correlation tomography of cerebral blood flow in rats. NeuroImage\| PubMed ID: 31112789	2019
Fractionated mitochondrial magnetic separation for isolation of synaptic mitochondria from brain tissue. Scientific reports\| PubMed ID: 31273236	2019
Therapeutic potential of natural compounds from Chinese medicine in acute and subacute phases of ischemic stroke. Neural regeneration research\| PubMed ID: 31571650	2020
Insulin-like growth factor-1 overexpression increases long-term survival of posttrauma-born hippocampal neurons while inhibiting ectopic migration following traumatic brain injury. Acta neuropathologica communications\| PubMed ID: 32276671	2020
Calpastatin Overexpression Protects against Excitotoxic Hippocampal Injury and Traumatic Spinal Cord Injury. Journal of neurotrauma\| PubMed ID: 32718209	2020
Speckle contrast diffuse correlation tomography of cerebral blood flow in perinatal disease model of neonatal piglets. Journal of biophotonics\| PubMed ID: 33295142	2021
Differential Leukocyte and Platelet Profiles in Distinct Models of Traumatic Brain Injury. Cells\| PubMed ID: 33652745	2021
IGF1-Stimulated Posttraumatic Hippocampal Remodeling Is Not Dependent on mTOR. Frontiers in cell and developmental biology\| PubMed ID: 34095131	2021
A role for insulin-like growth factor-1 in hippocampal plasticity following traumatic brain injury. Vitamins and hormones\| PubMed ID: 35180936	2022
Tissue factor release following traumatic brain injury drives thrombin generation. Research and practice in thrombosis and haemostasis\| PubMed ID: 35702585	2022
Peer-induced cocaine seeking in rats: Comparison to nonsocial stimuli and role of paraventricular hypothalamic oxytocin neurons. Addiction biology\| PubMed ID: 36001434	2022
The endogenous calpain inhibitor calpastatin attenuates axon degeneration in murine Guillain-Barré syndrome. Journal of the peripheral nervous system : JPNS\| PubMed ID: 36335586	2023
Depth-sensitive diffuse speckle contrast topography for high-density mapping of cerebral blood flow in rodents. Neurophotonics\| PubMed ID: 38076725	2023
EcoHIV-Infected Mice Show No Signs of Platelet Activation. Viruses\| PubMed ID: 38257755	2023
Acute gastrointestinal permeability after traumatic brain injury in mice precedes a bloom in Akkermansia muciniphila supported by intestinal hypoxia. Scientific reports\| PubMed ID: 38316862	2024
Nicorandil treatment improves survival and spatial learning in aged granulin knockout mice. Brain pathology (Zurich, Switzerland)\| PubMed ID: 39438022	2025
Sex-based differences in the long-term fate of hippocampal neurons born after a traumatic brain injury. Frontiers in behavioral neuroscience\| PubMed ID: 39974293	2025
Detection of low-frequency oscillations in neonatal piglets with speckle contrast diffuse correlation tomography. Journal of biomedical optics\| PubMed ID: 40060305	2023
Ubiquitous calpastatin overexpression in brain-injured mice attenuates motor and cognitive behavioral deficits without overt neuroprotection. Molecular and cellular neurosciences\| PubMed ID: 40706780	2025