generating-a-fractal-microstructure-of-laminin-111-to-signal-to-cells

Generating a Fractal Microstructure of Laminin-111 to Signal to Cells

Laminin-111 (Ln1) is an essential part of the extracellular matrix in epithelia, muscle and neural systems. We have previously demonstrated that the ...

Lawrence Livermore National Lab

Reconstruction plates permit contouring to the irregular anatomic shape of the clavicle. This study evaluated the biomechanical stability of locking and nonlocking clavicle reconstruction plates for treating midshaft, transverse fractures, comparing anterior-inferior to superior plate position. Twenty-four synthetic clavicles with mid-shaft fractures were repaired with either a locking or nonlocking clavicle reconstruction plate in either the anterior-inferior or superior plate position (n = 6/group). Repaired constructs were tested in axial compression, axial torsion, and cantilever bending failure. In compression, anterior-inferior plates were significantly stiffer than superior plates and locked plates stiffer than nonlocked. In torsion, anterior-inferior plates were stiffer, with a significant interaction term that favored anterior-inferior locked and superior nonlocked plates. In cantilever bending, superior plates had a significantly higher bending failure load and stiffness. Anterior-inferior plates failed at a significantly lower load ( approximately 40 N or approximately 4 kg), which could potentially occur in the postoperative period.

Reconstruction plates for stabilization of mid-shaft clavicle fractures: differences between nonlocked and locked plates in two different positions.

Decoding hormones for a stem cell niche.

In patients with myelodysplastic syndrome (MDS), bone marrow cells have an increased predisposition to apoptosis, yet MDS cells outcompete normal bone marrow (BM)-- suggesting that factors regulating growth potential may be important in MDS. We previously identified v-Erb A related-2 (EAR-2, NR2F6) as a gene involved in control of growth ability.

Article	Year
Reconstruction plates for stabilization of mid-shaft clavicle fractures: differences between nonlocked and locked plates in two different positions. Journal of shoulder and elbow surgery\| PubMed ID: 19111476	2009
Decoding hormones for a stem cell niche. Science (New York, N.Y.)\| PubMed ID: 28428385	2017
The orphan nuclear receptor EAR-2 (NR2F6) inhibits hematopoietic cell differentiation and induces myeloid dysplasia in vivo. Biomarker research\| PubMed ID: 30555701	2018

Claire Robertson

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