Michael Dustin

Helen and Martin S. Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular, New York University - NYU

Affiliated withNew York University - NYU

Research Area

Biology

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 17	2008

Other Publications

Article	Year
Costimulation and endogenous MHC ligands contribute to T cell recognition. Nature immunology\| PubMed ID: 11731799	2002
Membrane domains and the immunological synapse: keeping T cells resting and ready. The Journal of clinical investigation\| PubMed ID: 11805125	2002
T cell receptor signaling precedes immunological synapse formation. Science (New York, N.Y.)\| PubMed ID: 11859198	2002
WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation. Immunity\| PubMed ID: 11869681	2002
Polar redistribution of the sialoglycoprotein CD43: implications for T cell function. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 11937524	2002
Stimulation of naÃ¯ve T-cell adhesion and immunological synapse formation by chemokine-dependent and -independent mechanisms. Immunology\| PubMed ID: 12100716	2002
The immunological synapse. Arthritis research\| PubMed ID: 12110130	2002
Immature CD4(+)CD8(+) thymocytes form a multifocal immunological synapse with sustained tyrosine phosphorylation. Immunity\| PubMed ID: 12121665	2002
Shmoos, rafts, and uropods- the many facets of cell polarity. Cell\| PubMed ID: 12150993	2002
Cutting edge: quantitative imaging of raft accumulation in the immunological synapse. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12218094	2002
T-cell activation: a multidimensional signaling network. Current opinion in cell biology\| PubMed ID: 12231352	2002
The immunological synapse: integrins take the stage. Immunological reviews\| PubMed ID: 12234366	2002
Correlation of a dynamic model for immunological synapse formation with effector functions: two pathways to synapse formation. Trends in immunology\| PubMed ID: 12297421	2002
The synapse assembly model. Trends in immunology\| PubMed ID: 12297422	2002
Neural and immunological synaptic relations. Science (New York, N.Y.)\| PubMed ID: 12399580	2002
Regulation of T cell migration through formation of immunological synapses: the stop signal hypothesis. Advances in experimental medicine and biology\| PubMed ID: 12405204	2002
Viral spread through protoplasmic kiss. Nature cell biology\| PubMed ID: 12669071	2003
Coordination of T cell activation and migration through formation of the immunological synapse. Annals of the New York Academy of Sciences\| PubMed ID: 12727623	2003
In vivo imaging approaches in animal models of rheumatoid arthritis. Arthritis research & therapy\| PubMed ID: 12823846	2003
Supported planar bilayers in studies on immune cell adhesion and communication. Journal of immunological methods\| PubMed ID: 12957393	2003
The immunological synapse balances T cell receptor signaling and degradation. Science (New York, N.Y.)\| PubMed ID: 14512504	2003
In silico models for cellular and molecular immunology: successes, promises and challenges. Nature immunology\| PubMed ID: 14515121	2003
Cytotoxic T lymphocytes form an antigen-independent ring junction. The Journal of clinical investigation\| PubMed ID: 14702108	2004
Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nature immunology\| PubMed ID: 14973438	2004
Membranes as messengers in T cell adhesion signaling. Nature immunology\| PubMed ID: 15052266	2004
A supercode for inflammation. Immunity\| PubMed ID: 15084264	2004
LFA-1/ICAM-1 interaction lowers the threshold of B cell activation by facilitating B cell adhesion and synapse formation. Immunity\| PubMed ID: 15142527	2004
What is the importance of the immunological synapse? Trends in immunology\| PubMed ID: 15145322	2004
T cell receptor antagonism interferes with MHC clustering and integrin patterning during immunological synapse formation. The Journal of cell biology\| PubMed ID: 15314068	2004
Stop and go traffic to tune T cell responses. Immunity\| PubMed ID: 15357942	2004
A polarizing situation. Nature immunology\| PubMed ID: 15454929	2004
Visualizing dendritic cell networks in vivo. Nature immunology\| PubMed ID: 15543150	2004
Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids. PLoS biology\| PubMed ID: 15799695	2005
Distinct role of lymphocyte function-associated antigen-1 in mediating effective cytolytic activity by cytotoxic T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15851656	2005
ICAM-1 co-stimulates target cells to facilitate antigen presentation. Current opinion in immunology\| PubMed ID: 15886114	2005
ATP mediates rapid microglial response to local brain injury in vivo. Nature neuroscience\| PubMed ID: 15895084	2005
A model for CD2/CD58-mediated adhesion strengthening. Annals of biomedical engineering\| PubMed ID: 15909654	2005
Stable T cell-dendritic cell interactions precede the development of both tolerance and immunity in vivo. Nature immunology\| PubMed ID: 15924144	2005
A molecular dissection of lymphocyte unresponsiveness induced by sustained calcium signalling. Novartis Foundation symposium\| PubMed ID: 15999806	2005
Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling. The Journal of experimental medicine\| PubMed ID: 16216891	2005
A dynamic view of the immunological synapse. Seminars in immunology\| PubMed ID: 16266811	2005
Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76. Nature immunology\| PubMed ID: 16273097	2005
Altered TCR signaling from geometrically repatterned immunological synapses. Science (New York, N.Y.)\| PubMed ID: 16293763	2005
CD80 cytoplasmic domain controls localization of CD28, CTLA-4, and protein kinase Ctheta in the immunological synapse. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16339518	2005
Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo. The Journal of experimental medicine\| PubMed ID: 16533880	2006
T cells like a firm molecular handshake. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16537367	2006
T cell-dendritic cell immunological synapses. Current opinion in immunology\| PubMed ID: 16777399	2006
Dynamic imaging of the immune system: progress, pitfalls and promise. Nature reviews. Immunology\| PubMed ID: 16799470	2006
T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. Immunity\| PubMed ID: 16860761	2006
Immunology. When F-actin becomes too much of a good thing. Science (New York, N.Y.)\| PubMed ID: 16902113	2006
Lateral membrane waves constitute a universal dynamic pattern of motile cells. Physical review letters\| PubMed ID: 16907546	2006
Innate response to focal necrotic injury inside the blood-brain barrier. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17015712	2006
Impact of the immunological synapse on T cell signaling. Results and problems in cell differentiation\| PubMed ID: 17068972	2006
Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17077145	2006
Analysis of two-dimensional dissociation constant of laterally mobile cell adhesion molecules. Biophysical journal\| PubMed ID: 17085486	2007
Control of antigen presentation with a photoreleasable agonist peptide. Journal of the American Chemical Society\| PubMed ID: 17131984	2006
Mechanisms of Cellular Avidity Regulation in CD2-CD58-Mediated T Cell Adhesion. ACS chemical biology\| PubMed ID: 17168569	2006
Force as a facilitator of integrin conformational changes during leukocyte arrest on blood vessels and antigen-presenting cells. Immunity\| PubMed ID: 17241958	2007
In vivo imaging of germinal centres reveals a dynamic open structure. Nature\| PubMed ID: 17268470	2007
The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2. Nature cell biology\| PubMed ID: 17486117	2007
Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse. Cell\| PubMed ID: 17512410	2007
Requirements for T lymphocyte migration in explanted lymph nodes. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17548612	2007
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling. Immunological reviews\| PubMed ID: 17624948	2007
Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes. Nature immunology\| PubMed ID: 17632517	2007
Quantification and modeling of tripartite CD2-, CD58FC chimera (alefacept)-, and CD16-mediated cell adhesion. The Journal of biological chemistry\| PubMed ID: 17911103	2007
Cell adhesion molecules and actin cytoskeleton at immune synapses and kinapses. Current opinion in cell biology\| PubMed ID: 17923403	2007
Dynamics of host defense: the view at the front lines. Nature immunology\| PubMed ID: 17952039	2007
Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18077330	2007
Tug of war at the exit door. Immunity\| PubMed ID: 18199414	2008
T cell receptor microcluster transport through molecular mazes reveals mechanism of translocation. Biophysical journal\| PubMed ID: 18199675	2008
Cutting edge: activation by innate cytokines or microbial antigens can cause arrest of natural killer T cell patrolling of liver sinusoids. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18250405	2008
T-cell activation through immunological synapses and kinapses. Immunological reviews\| PubMed ID: 18275476	2008
Synaptic asymmetry to go. Cell\| PubMed ID: 18329360	2008
Measuring diffusion and binding kinetics by contact area FRAP. Biophysical journal\| PubMed ID: 18390627	2008
A coupled diffusion-kinetics model for analysis of contact-area FRAP experiment. Biophysical journal\| PubMed ID: 18390628	2008
Supported planar bilayers for study of the immunological synapse. Current protocols in immunology / edited by John E. Coligan ... [et al.]\| PubMed ID: 18432988	2007
Micropatterning of costimulatory ligands enhances CD4+ T cell function. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18505845	2008
Th1 and Th2 cells form morphologically distinct immunological synapses. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18566405	2008
Hunter to gatherer and back: immunological synapses and kinapses as variations on the theme of amoeboid locomotion. Annual review of cell and developmental biology\| PubMed ID: 18598213	2008
Human immunodeficiency virus type 1 envelope gp120 induces a stop signal and virological synapse formation in noninfected CD4+ T cells. Journal of virology\| PubMed ID: 18632854	2008
Modulation of T cell activation by stomatin-like protein 2. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18641330	2008
Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18713980	2008
Protein kinase C theta regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18802085	2008
T cell-dendritic cell immunological synapses contain TCR-dependent CD28-CD80 clusters that recruit protein kinase C theta. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18802089	2008
Nanoscale increases in CD2-CD48-mediated intermembrane spacing decrease adhesion and reorganize the immunological synapse. The Journal of biological chemistry\| PubMed ID: 18826951	2008
Lrp4 is a receptor for Agrin and forms a complex with MuSK. Cell\| PubMed ID: 18848351	2008
Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation. Immunity\| PubMed ID: 18848472	2008
Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis. Nature\| PubMed ID: 19011611	2009
Visualization of cell-cell interaction contacts-synapses and kinapses. Advances in experimental medicine and biology\| PubMed ID: 19065791	2008
betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis. Molecular cell\| PubMed ID: 19150432	2009
Renal dendritic cells: an update. Nephron. Experimental nephrology\| PubMed ID: 19276627	2009
Phospholipase D1 regulates lymphocyte adhesion via upregulation of Rap1 at the plasma membrane. Molecular and cellular biology\| PubMed ID: 19332557	2009
T cell antigen receptor signaling and immunological synapse stability require myosin IIA. Nature immunology\| PubMed ID: 19349987	2009
Visualizing immune system complexity. Science signaling\| PubMed ID: 19366990	2009
The cellular context of T cell signaling. Immunity\| PubMed ID: 19371714	2009
The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells. The Journal of cell biology\| PubMed ID: 19398758	2009
Supported bilayers at the vanguard of immune cell activation studies. Journal of structural biology\| PubMed ID: 19500675	2009
Multiscale analysis of T cell activation: correlating in vitro and in vivo analysis of the immunological synapse. Current topics in microbiology and immunology\| PubMed ID: 19521681	2009
CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia. Nature\| PubMed ID: 19536265	2009
The class II phosphatidylinositol 3 kinase C2beta is required for the activation of the K+ channel KCa3.1 and CD4 T-cells. Molecular biology of the cell\| PubMed ID: 19587117	2009
Integrin-dependent organization and bidirectional vesicular traffic at cytotoxic immune synapses. Immunity\| PubMed ID: 19592272	2009
Feedback control of regulatory T cell homeostasis by dendritic cells in vivo. The Journal of experimental medicine\| PubMed ID: 19667061	2009
Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19706535	2009
Human immunodeficiency virus type 1 envelope gp120-induced partial T-cell receptor signaling creates an F-actin-depleted zone in the virological synapse. Journal of virology\| PubMed ID: 19710135	2009
Two-photon laser scanning microscopy imaging of intact spinal cord and cerebral cortex reveals requirement for CXCR6 and neuroinflammation in immune cell infiltration of cortical injury site... Journal of immunological methods\| PubMed ID: 19800886	2010
Kinetics of early T cell receptor signaling regulate the pathway of lytic granule delivery to the secretory domain. Immunity\| PubMed ID: 19833088	2009
Insights into function of the immunological synapse from studies with supported planar bilayers. Current topics in microbiology and immunology\| PubMed ID: 19960306	2010
Functional anatomy of T cell activation and synapse formation. Annual review of immunology\| PubMed ID: 19968559	2010
Modular design of immunological synapses and kinapses. Cold Spring Harbor perspectives in biology\| PubMed ID: 20066081	2009
Protein kinase C-theta mediates negative feedback on regulatory T cell function. Science (New York, N.Y.)\| PubMed ID: 20339032	2010
Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster. Immunity\| PubMed ID: 20399684	2010
Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expression. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20435926	2010
Affinity measured by microcluster. The Journal of experimental medicine\| PubMed ID: 20439542	2010
Cytotoxic immunological synapses. Immunological reviews\| PubMed ID: 20536553	2010
High plasma membrane lipid order imaged at the immunological synapse periphery in live T cells. Molecular membrane biology\| PubMed ID: 20540668	2010
Development and migration of plasma cells in the mouse lymph node. Immunity\| PubMed ID: 20619695	2010
Understanding the structure and function of the immunological synapse. Cold Spring Harbor perspectives in biology\| PubMed ID: 20843980	2010
HIV-1 Virological Synapse is not Simply a Copycat of the Immunological Synapse. Viruses\| PubMed ID: 20890395	2010
Signaling microdomains in T cells. FEBS letters\| PubMed ID: 20965175	2010
CTLs respond with activation and granule secretion when serving as targets for T-cell recognition. Blood\| PubMed ID: 21045195	2011
Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell\| PubMed ID: 21074050	2010
The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Science (New York, N.Y.)\| PubMed ID: 21393509	2011
Dynamic imaging of the effector immune response to listeria infection in vivo. PLoS pathogens\| PubMed ID: 21455492	2011
Migration of cytotoxic lymphocytes in cell cycle permits local MHC I-dependent control of division at sites of viral infection. The Journal of experimental medicine\| PubMed ID: 21464219	2011
Induction by IL 1 and interferon-Î³: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J. Immunol. 1986. 137: 245-254. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21505214	2011
A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J. Immunol. 1986. 137: 1270-1274. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21505215	2011
Nanoengineering of Immune Cell Function. Materials Research Society symposia proceedings. Materials Research Society\| PubMed ID: 21562611	2009
A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center. The Journal of experimental medicine\| PubMed ID: 21576382	2011
T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21576490	2011
A biophysical model of cell adhesion mediated by immunoadhesin drugs and antibodies. PloS one\| PubMed ID: 21629715	2011
The critical role of agrin in the hematopoietic stem cell niche. Blood\| PubMed ID: 21653324	2011
PKC-Î¸ function at the immunological synapse: prospects for therapeutic targeting. Trends in immunology\| PubMed ID: 21733754	2011
Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain. The Journal of experimental medicine\| PubMed ID: 21788405	2011
Boltzmann energy-based image analysis demonstrates that extracellular domain size differences explain protein segregation at immune synapses. PLoS computational biology\| PubMed ID: 21829338	2011
HIV envelope gp120 activates LFA-1 on CD4 T-lymphocytes and increases cell susceptibility to LFA-1-targeting leukotoxin (LtxA). PloS one\| PubMed ID: 21850260	2011
New insights into the T cell synapse from single molecule techniques. Nature reviews. Immunology\| PubMed ID: 21904389	2011
PKC-Î¸: hitting the bull's eye. Nature immunology\| PubMed ID: 22012436	2011
Integrin inside-out signaling and the immunological synapse. Current opinion in cell biology\| PubMed ID: 22129583	2011
Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22223661	2012
Immunology. Antigen feast or famine. Science (New York, N.Y.)\| PubMed ID: 22282794	2012
Visualization of Cell-Cell Interaction Contacts: Synapses and Kinapses. Self/nonself\| PubMed ID: 22299060	2011
Scaffold protein Disc large homolog 1 is required for T-cell receptor-induced activation of regulatory T-cell function. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22307621	2012
Self-reactive human CD4 T cell clones form unusual immunological synapses. The Journal of experimental medicine\| PubMed ID: 22312112	2012