Christopher C. Glembotski

San Diego State University Heart Institute and the Department of Biology, San Diego State University

Affiliated withSan Diego State University

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 9	2020

Other Publications

Article	Year
A role for the p38 mitogen-activated protein kinase pathway in myocardial cell growth, sarcomeric organization, and cardiac-specific gene expression. The Journal of cell biology\| PubMed ID: 9314533	1997
Coordination of ATF6-mediated transcription and ATF6 degradation by a domain that is shared with the viral transcription factor, VP16. The Journal of biological chemistry\| PubMed ID: 11909875	2002
Expression and functional characterization of SCaMPER: a sphingolipid-modulated calcium channel of cardiomyocytes. American journal of physiology. Cell physiology\| PubMed ID: 12421694	2003
Mimicking phosphorylation of alphaB-crystallin on serine-59 is necessary and sufficient to provide maximal protection of cardiac myocytes from apoptosis. Circulation research\| PubMed ID: 12574148	2003
Factor associated with neutral sphingomyelinase activation and its role in cardiac cell death. Circulation research\| PubMed ID: 12637370	2003
Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction. The Journal of biological chemistry\| PubMed ID: 14973138	2004
Overexpression of mitogen-activated protein kinase kinase 6 in the heart improves functional recovery from ischemia in vitro and protects against myocardial infarction in vivo. The Journal of biological chemistry\| PubMed ID: 15492008	2005
Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt. The Journal of clinical investigation\| PubMed ID: 16200208	2005
Endoplasmic reticulum stress gene induction and protection from ischemia/reperfusion injury in the hearts of transgenic mice with a tamoxifen-regulated form of ATF6. Circulation research\| PubMed ID: 16601230	2006
Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes. Circulation research\| PubMed ID: 16794188	2006
Effects of the isoform-specific characteristics of ATF6 alpha and ATF6 beta on endoplasmic reticulum stress response gene expression and cell viability. The Journal of biological chemistry\| PubMed ID: 17522056	2007
Getting a G--RRP on regulated exocytosis in the heart. The Journal of cell biology\| PubMed ID: 17967951	2007
Endoplasmic reticulum stress in the heart. Circulation research\| PubMed ID: 17991891	2007
Pim-1 regulates cardiomyocyte survival downstream of Akt. Nature medicine\| PubMed ID: 18037896	2007
The role of the unfolded protein response in the heart. Journal of molecular and cellular cardiology\| PubMed ID: 18054039	2008
Coordination of growth and endoplasmic reticulum stress signaling by regulator of calcineurin 1 (RCAN1), a novel ATF6-inducible gene. The Journal of biological chemistry\| PubMed ID: 18319259	2008
Mesencephalic astrocyte-derived neurotrophic factor is an ischemia-inducible secreted endoplasmic reticulum stress response protein in the heart. Circulation research\| PubMed ID: 18927462	2008
LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 19098111	2009
Ischemia activates the ATF6 branch of the endoplasmic reticulum stress response. The Journal of biological chemistry\| PubMed ID: 19622751	2009
The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 19667116	2009
Roles for endoplasmic reticulum-associated degradation and the novel endoplasmic reticulum stress response gene Derlin-3 in the ischemic heart. Circulation research\| PubMed ID: 19940266	2010
Pim-1 kinase protects mitochondrial integrity in cardiomyocytes. Circulation research\| PubMed ID: 20203306	2010
Functions for the cardiomyokine, MANF, in cardioprotection, hypertrophy and heart failure. Journal of molecular and cellular cardiology\| PubMed ID: 20970425	2011
The cardiokine story unfolds: ischemic stress-induced protein secretion in the heart. Trends in molecular medicine\| PubMed ID: 21277256	2011
Regulation of microRNA expression in the heart by the ATF6 branch of the ER stress response. Journal of molecular and cellular cardiology\| PubMed ID: 22326432	2012
Protein disulfide isomerase-associated 6 is an ATF6-inducible ER stress response protein that protects cardiac myocytes from ischemia/reperfusion-mediated cell death. Journal of molecular and cellular cardiology\| PubMed ID: 22609432	2012
Mesencephalic astrocyte-derived neurotrophic factor protects the heart from ischemic damage and is selectively secreted upon sarco/endoplasmic reticulum calcium depletion. The Journal of biological chemistry\| PubMed ID: 22637475	2012
Limitation of individual folding resources in the ER leads to outcomes distinct from the unfolded protein response. Journal of cell science\| PubMed ID: 22854046	2012
Clarifying the cardiac proteasome paradox: protein quality control. Circulation research\| PubMed ID: 22904038	2012
New concepts of endoplasmic reticulum function in the heart: programmed to conserve. Journal of molecular and cellular cardiology\| PubMed ID: 23085588	2013
Roles for the sarco-/endoplasmic reticulum in cardiac myocyte contraction, protein synthesis, and protein quality control. Physiology (Bethesda, Md.)\| PubMed ID: 23223628	2012
ATF6 [corrected] and thrombospondin 4: the dynamic duo of the adaptive endoplasmic reticulum stress response. Circulation research\| PubMed ID: 23287452	2013
Regulation of cardiac hypertrophic signaling by prolyl isomerase Pin1. Circulation research\| PubMed ID: 23487407	2013
Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23842089	2013
Mechanistic target of rapamycin complex 2 protects the heart from ischemic damage. Circulation\| PubMed ID: 24008870	2013
Roles for ATF6 and the sarco/endoplasmic reticulum protein quality control system in the heart. Journal of molecular and cellular cardiology\| PubMed ID: 24140798	2014
Classic studies of cultured cardiac myocyte hypertrophy: interview with a transformer. Circulation research\| PubMed ID: 24158575	2013
Finding the missing link between the unfolded protein response and O-GlcNAcylation in the heart. Circulation research\| PubMed ID: 25170091	2014
Hrd1 and ER-Associated Protein Degradation, ERAD, are Critical Elements of the Adaptive ER Stress Response in Cardiac Myocytes. Circulation research\| PubMed ID: 26137860	2015
Breaking down the COP9 Signalsome in the heart: how inactivating a protein ubiquitin ligase increases protein ubiquitylation and protects the heart. Circulation research\| PubMed ID: 26541679	2015
Activation of the ATF6 branch of the unfolded protein response in neurons improves stroke outcome. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 27217380	2017
S100A4 protects the myocardium against ischemic stress. Journal of molecular and cellular cardiology\| PubMed ID: 27721024	2016
Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca release. International journal of cardiology\| PubMed ID: 27760414	2016
ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the Heart. Circulation research\| PubMed ID: 27932512	2017
CaMKIIδ subtypes differentially regulate infarct formation following ex vivo myocardial ischemia/reperfusion through NF-κB and TNF-α. Journal of molecular and cellular cardiology\| PubMed ID: 28077321	2017
Expanding the Paracrine Hypothesis of Stem Cell-Mediated Repair in the Heart: When the Unconventional Becomes Conventional. Circulation research\| PubMed ID: 28254800	2017
ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb. Circulation research\| PubMed ID: 30582446	2019
Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis. Nature communications\| PubMed ID: 30643122	2019
Unfolding the Roles of Mitochondria as Therapeutic Targets for Heart Disease. Journal of the American College of Cardiology\| PubMed ID: 30975298	2019
Proteostasis and Beyond: ATF6 in Ischemic Disease. Trends in molecular medicine\| PubMed ID: 31078432	2019
Physiological signaling in the absence of amidated peptides. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 31515450	2019
Integrating ER and Mitochondrial Proteostasis in the Healthy and Diseased Heart. Frontiers in cardiovascular medicine\| PubMed ID: 32010709	2019
Sledgehammer to Scalpel: Broad Challenges to the Heart and Other Tissues Yield Specific Cellular Responses via Transcriptional Regulation of the ER-Stress Master Regulator ATF6α. International journal of molecular sciences\| PubMed ID: 32046286	2020
The ER Unfolded Protein Response Effector, ATF6, Reduces Cardiac Fibrosis and Decreases Activation of Cardiac Fibroblasts. International journal of molecular sciences\| PubMed ID: 32085622	2020
Designing Novel Therapies to Mend Broken Hearts: ATF6 and Cardiac Proteostasis. Cells\| PubMed ID: 32138230	2020
Reactive Oxygen Species (ROS)-Activatable Prodrug for Selective Activation of ATF6 after Ischemia/Reperfusion Injury. ACS medicinal chemistry letters\| PubMed ID: 32184959	2020
ATF6 as a Nodal Regulator of Proteostasis in the Heart. Frontiers in physiology\| PubMed ID: 32322217	2020
Mesencephalic astrocyte-derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart. The Journal of biological chemistry\| PubMed ID: 32327487	2020
Proteomic analysis of the cardiac myocyte secretome reveals extracellular protective functions for the ER stress response. Journal of molecular and cellular cardiology\| PubMed ID: 32339566	2020