Birger Brodin

Department of Pharmacy, University of Copenhagen

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2020

Other Publications

Article	Year
hPEPT1 is responsible for uptake and transport of Gly-Sar in the human bronchial airway epithelial cell-line Calu-3. Pflugers Archiv : European journal of physiology\| PubMed ID: 18094991	2008
Cloning of the pig PEPT2 (pPEPT2) and characterization of the effects of epidermal growth factor (EGF) on pPEPT2-mediated peptide uptake in the renal porcine cell line LLC-PK1. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 18295462	2008
Discovery of ligands for the human intestinal Di-/Tripeptide transporter (hPEPT1) using a QSAR-assisted virtual screening strategy. ChemMedChem\| PubMed ID: 19557803	2009
In vitro cutaneous application of ISCOMs on human skin enhances delivery of hydrophobic model compounds through the stratum corneum. The AAPS journal\| PubMed ID: 19862629	2009
5-Hydroxy-L-tryptophan alters gaboxadol pharmacokinetics in rats: involvement of PAT1 and rOat1 in gaboxadol absorption and elimination. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 19900542	2010
A quantitative structure-activity relationship for translocation of tripeptides via the human proton-coupled peptide transporter, hPEPT1 (SLC15A1). The AAPS journal\| PubMed ID: 20449699	2010
Ibuprofen is a non-competitive inhibitor of the peptide transporter hPEPT1 (SLC15A1): possible interactions between hPEPT1 substrates and ibuprofen. British journal of pharmacology\| PubMed ID: 20726987	2010
Paracellular tightness and claudin-5 expression is increased in the BCEC/astrocyte blood-brain barrier model by increasing media buffer capacity during growth. The AAPS journal\| PubMed ID: 20967520	2010
Affinity and translocation relationships via hPEPT1 of H-X aa-Ser-OH dipeptides: evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 21147219	2011
Calu-3 cells grown under AIC and LCC conditions: implications for dipeptide uptake and transepithelial transport of substances. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 21195173	2011
In vitro evidence for the brain glutamate efflux hypothesis: brain endothelial cells cocultured with astrocytes display a polarized brain-to-blood transport of glutamate. Glia\| PubMed ID: 22392649	2012
Carrier-mediated γ-aminobutyric acid transport across the basolateral membrane of human intestinal Caco-2 cell monolayers. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 22452873	2012
In-vitro evaluation of the P-glycoprotein interactions of a series of potentially CNS-active Amaryllidaceae alkaloids. The Journal of pharmacy and pharmacology\| PubMed ID: 23058055	2012
Identification and Characterization of a Novel Nontranslated Sequence Variant of the Human Intestinal Di-/Tripeptide Transporter, hPEPT1. International journal of peptides\| PubMed ID: 23346117	2012
Basolateral glycylsarcosine (Gly-Sar) transport in Caco-2 cell monolayers is pH dependent. The Journal of pharmacy and pharmacology\| PubMed ID: 23738724	2013
The absorptive flux of the anti-epileptic drug substance vigabatrin is carrier-mediated across Caco-2 cell monolayers. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 24008184	2014
PAT1 (SLC36A1) shows nuclear localization and affects growth of smooth muscle cells from rats. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 24222668	2014
Generation of primary cultures of bovine brain endothelial cells and setup of cocultures with rat astrocytes. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 24510879	2014
In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated Dmt-DALDA Analogues. ACS medicinal chemistry letters\| PubMed ID: 24839540	2014
An electrically tight in vitro blood-brain barrier model displays net brain-to-blood efflux of substrates for the ABC transporters, P-gp, Bcrp and Mrp-1. The AAPS journal\| PubMed ID: 24934296	2014
Glutamate efflux at the blood-brain barrier: cellular mechanisms and potential clinical relevance. Archives of medical research\| PubMed ID: 25446623	2014
Intestinal absorption of the antiepileptic drug substance vigabatrin is altered by infant formula in vitro and in vivo. Pharmacology research & perspectives\| PubMed ID: 25505585	2014
In Vitro Blood-Brain Barrier Models-An Overview of Established Models and New Microfluidic Approaches. Journal of pharmaceutical sciences\| PubMed ID: 25630899	2015
The putative P-gp inhibitor telmisartan does not affect the transcellular permeability and cellular uptake of the calcium channel antagonist verapamil in the P-glycoprotein expressing cell l... Pharmacology research & perspectives\| PubMed ID: 26171231	2015
In vitro models of the blood-brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 26868179	2016
Stroke and Drug Delivery--In Vitro Models of the Ischemic Blood-Brain Barrier. Journal of pharmaceutical sciences\| PubMed ID: 26869407	2016
In vitro blood-brain barrier permeability predictions for GABAA receptor modulating piperine analogs. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 27018328	2016
Transferrin receptor expression and role in transendothelial transport of transferrin in cultured brain endothelial monolayers. Molecular and cellular neurosciences\| PubMed ID: 27567687	2016
Characterization of the L-glutamate clearance pathways across the blood-brain barrier and the effect of astrocytes in an in vitro blood-brain barrier model. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 28145808	2017
Bidirectional apical-basal traffic of the cation-independent mannose-6-phosphate receptor in brain endothelial cells. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 28337939	2017
A Critical View on In Vitro Analysis of P-glycoprotein (P-gp) Transport Kinetics. Journal of pharmaceutical sciences\| PubMed ID: 28438535	2017
Routes for Drug Translocation Across the Blood-Brain Barrier: Exploiting Peptides as Delivery Vectors. Journal of pharmaceutical sciences\| PubMed ID: 28501469	2017
Glutamate Transporters in the Blood-Brain Barrier. Advances in neurobiology\| PubMed ID: 28828617	2017
Evaluating the involvement of cerebral microvascular endothelial Na/K-ATPase and Na-K-2Cl co-transporter in electrolyte fluxes in an in vitro blood-brain barrier model of dehydration. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 28994331	2019
Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017. Fluids and barriers of the CNS\| PubMed ID: 29110676	2017
Characterization of the IPEC-J2 MDR1 (iP-gp) cell line as a tool for identification of P-gp substrates. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 29146563	2018
Correction to: Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017. Fluids and barriers of the CNS\| PubMed ID: 29329565	2018
Data demonstrating the challenges of determining the kinetic parameters of P-gp mediated transport of low-water soluble substrates. Data in brief\| PubMed ID: 29541662	2018
The insulin receptor is expressed and functional in cultured blood-brain barrier endothelial cells but does not mediate insulin entry from blood to brain. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 29584446	2018
Stimulation-induced increases in cerebral blood flow and local capillary vasoconstriction depend on conducted vascular responses. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29866853	2018
Validation of reference genes for normalization of real-time quantitative PCR studies of gene expression in brain capillary endothelial cells cultured in vitro. Molecular and cellular neurosciences\| PubMed ID: 30315869	2018
Effects of oxygen-glucose deprivation (OGD) on barrier properties and mRNA transcript levels of selected marker proteins in brain endothelial cells/astrocyte co-cultures. PloS one\| PubMed ID: 31425564	2019
The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP. Cells\| PubMed ID: 32143347	2020
Culture-induced changes in mRNA expression levels of efflux and SLC-transporters in brain endothelial cells. Fluids and barriers of the CNS\| PubMed ID: 32321539	2020