Alexander Klibanov

Department of Medicine, University of Virginia

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2020

Other Publications

Article	Year
Noninvasive imaging of myocardial reperfusion injury using leukocyte-targeted contrast echocardiography. Circulation\| PubMed ID: 11956115	2002
Detection of individual microbubbles of an ultrasound contrast agent: fundamental and pulse inversion imaging. Academic radiology\| PubMed ID: 12188248	2002
Influence of microbubble surface charge on capillary transit and myocardial contrast enhancement. Journal of the American College of Cardiology\| PubMed ID: 12204515	2002
Noninvasive assessment of angiogenesis by ultrasound and microbubbles targeted to alpha(v)-integrins. Circulation\| PubMed ID: 12551871	2003
Imaging tumor angiogenesis with contrast ultrasound and microbubbles targeted to alpha(v)beta3. Circulation\| PubMed ID: 12835208	2003
Targeted tissue transfection with ultrasound destruction of plasmid-bearing cationic microbubbles. Ultrasound in medicine & biology\| PubMed ID: 14698343	2003
Detection of individual microbubbles of ultrasound contrast agents: imaging of free-floating and targeted bubbles. Investigative radiology\| PubMed ID: 15076011	2004
Binding and detachment dynamics of microbubbles targeted to P-selectin under controlled shear flow. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 15120903	2004
Microvascular recruitment is an early insulin effect that regulates skeletal muscle glucose uptake in vivo. Diabetes\| PubMed ID: 15161743	2004
Molecular imaging with targeted ultrasound contrast microbubbles. Ernst Schering Research Foundation workshop\| PubMed ID: 15524217	2005
Ligand-carrying gas-filled microbubbles: ultrasound contrast agents for targeted molecular imaging. Bioconjugate chemistry\| PubMed ID: 15656569	2005
Acoustic radiation force enhances targeted delivery of ultrasound contrast microbubbles: in vitro verification. IEEE transactions on ultrasonics, ferroelectrics, and frequency control\| PubMed ID: 15857050	2005
Simultaneous integrin alphavbeta3 and glycoprotein IIb/IIIa inhibition causes reduction in infarct size in a model of acute coronary thrombosis and primary angioplasty. Cardiovascular research\| PubMed ID: 15914120	2005
Assessment of endogenous and therapeutic arteriogenesis by contrast ultrasound molecular imaging of integrin expression. Circulation\| PubMed ID: 15956135	2005
Ultrasound-microbubble-induced neovascularization in mouse skeletal muscle. Ultrasound in medicine & biology\| PubMed ID: 16223645	2005
Targeting mucosal addressin cellular adhesion molecule (MAdCAM)-1 to noninvasively image experimental Crohn's disease. Gastroenterology\| PubMed ID: 16401463	2006
Microbubble contrast agents: targeted ultrasound imaging and ultrasound-assisted drug-delivery applications. Investigative radiology\| PubMed ID: 16481920	2006
3D perfusion mapping in post-infarct mice using myocardial contrast echocardiography. Ultrasound in medicine & biology\| PubMed ID: 16785003	2006
Deformable gas-filled microbubbles targeted to P-selectin. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 16887229	2006
Microparticle adhesive dynamics and rolling mediated by selectin-specific antibodies under flow. Biotechnology and bioengineering\| PubMed ID: 16917925	2007
Effect of microbubble ligation to cells on ultrasound signal enhancement: implications for targeted imaging. Investigative radiology\| PubMed ID: 16971795	2006
Targeted ultrasound contrast agent for molecular imaging of inflammation in high-shear flow. Contrast media & molecular imaging\| PubMed ID: 17191766	2006
Enhanced targeting of ultrasound contrast agents using acoustic radiation force. Ultrasound in medicine & biology\| PubMed ID: 17445966	2007
BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module. Nature\| PubMed ID: 17960134	2007
Ultrasound molecular imaging with targeted microbubble contrast agents. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology\| PubMed ID: 18022115	2007
Ultrasonic microbubble destruction stimulates therapeutic arteriogenesis via the CD18-dependent recruitment of bone marrow-derived cells. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 18403725	2008
Acoustic attenuation by contrast agent microbubbles in superficial tissue markedly diminishes petechiae bioeffects in deep tissue. Investigative radiology\| PubMed ID: 18424953	2008
Microbubbles in ultrasound-triggered drug and gene delivery. Advanced drug delivery reviews\| PubMed ID: 18486268	2008
Targeted delivery of nanoparticles bearing fibroblast growth factor-2 by ultrasonic microbubble destruction for therapeutic arteriogenesis. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 18720443	2008
Preparation of targeted microbubbles: ultrasound contrast agents for molecular imaging. Medical & biological engineering & computing\| PubMed ID: 19517153	2009
Action at a distance: lengthening adhesion bonds with poly(ethylene glycol) spacers enhances mechanically stressed affinity for improved vascular targeting of microparticles. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 19621909	2009
Muscle contraction, but not insulin, increases microvascular blood volume in the presence of free fatty acid-induced insulin resistance. Diabetes\| PubMed ID: 19675134	2009
Dual frequency method for simultaneous translation and real-time imaging of ultrasound contrast agents within large blood vessels. Ultrasound in medicine & biology\| PubMed ID: 19828229	2009
Focused in vivo delivery of plasmid DNA to the porcine vascular wall via intravascular ultrasound destruction of microbubbles. Journal of vascular research\| PubMed ID: 19923850	2010
Molecular imaging of atherosclerotic plaques targeted to oxidized LDL receptor LOX-1 by SPECT/CT and magnetic resonance. Circulation. Cardiovascular imaging\| PubMed ID: 20442371	2010
Ultrasound-triggered release of materials entrapped in microbubble-liposome constructs: a tool for targeted drug delivery. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 20691227	2010
Targeted gene transfection from microbubbles into vascular smooth muscle cells using focused, ultrasound-mediated delivery. Ultrasound in medicine & biology\| PubMed ID: 20800174	2010
Analysis of in vitro transfection by sonoporation using cationic and neutral microbubbles. Ultrasound in medicine & biology\| PubMed ID: 20800945	2010
An ultrasound contrast agent targeted to P-selectin detects activated platelets at supra-arterial shear flow conditions. Investigative radiology\| PubMed ID: 20808239	2010
Inhibition of glioma growth by microbubble activation in a subcutaneous model using low duty cycle ultrasound without significant heating. Journal of neurosurgery\| PubMed ID: 21214331	2011
Real-time technique for improving molecular imaging and guiding drug delivery in large blood vessels: in vitro and ex vivo results. Molecular imaging\| PubMed ID: 21521555	2011
Localized ultrasound enhances delivery of rapamycin from microbubbles to prevent smooth muscle proliferation. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 21549778	2011
Phagocytic activity of neuronal progenitors regulates adult neurogenesis. Nature cell biology\| PubMed ID: 21804544	2011
Microglial cells contribute to endogenous brain defenses after acute neonatal focal stroke. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21900578	2011
Focused ultrasound-mediated drug delivery from microbubbles reduces drug dose necessary for therapeutic effect on neointima formation--brief report. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 21960561	2011
Inhibitor of differentiation-3 mediates high fat diet-induced visceral fat expansion. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 22075252	2012
Nanobody-coupled microbubbles as novel molecular tracer. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 22197777	2012
Monocyte and/or macrophage infiltration of heart after myocardial infarction: MR imaging by using T1-shortening liposomes. Radiology\| PubMed ID: 22723500	2012
Markedly enhanced skeletal muscle transfection achieved by the ultrasound-targeted delivery of non-viral gene nanocarriers with microbubbles. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 22800583	2012
Microbubbles as ultrasound contrast agents for molecular imaging: preparation and application. AJR. American journal of roentgenology\| PubMed ID: 22826389	2012
Ultrasound-based molecular imaging and specific gene delivery to mesenteric vasculature by endothelial adhesion molecule targeted microbubbles in a mouse model of Crohn's disease. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 23142578	2013
Intravascular ultrasound catheter to enhance microbubble-based drug delivery via acoustic radiation force. IEEE transactions on ultrasonics, ferroelectrics, and frequency control\| PubMed ID: 23143566	2012
Ultrasound-mediated vascular gene transfection by cavitation of endothelial-targeted cationic microbubbles. JACC. Cardiovascular imaging\| PubMed ID: 23236976	2012
Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion. Nature\| PubMed ID: 23615608	2013
Ultrasound prevents renal ischemia-reperfusion injury by stimulating the splenic cholinergic anti-inflammatory pathway. Journal of the American Society of Nephrology : JASN\| PubMed ID: 23907510	2013
Ultrasound contrast materials in cardiovascular medicine: from perfusion assessment to molecular imaging. Journal of cardiovascular translational research\| PubMed ID: 23913363	2013
MR-guided focused ultrasound surgery, present and future. Medical physics\| PubMed ID: 23927296	2013
Shear forces from flow are responsible for a distinct statistical signature of adherent microbubbles in large vessels. Molecular imaging\| PubMed ID: 23981785	2013
Synthesis and characterization of transiently stable albumin-coated microbubbles via a flow-focusing microfluidic device. Ultrasound in medicine & biology\| PubMed ID: 24342914	2014
Binding dynamics of targeted microbubbles in response to modulated acoustic radiation force. Physics in medicine and biology\| PubMed ID: 24374866	2014
Nucleic acid delivery with microbubbles and ultrasound. Advanced drug delivery reviews\| PubMed ID: 24486388	2014
Imaging flow cytometry elucidates limitations of microparticle analysis by conventional flow cytometry. Cytometry. Part A : the journal of the International Society for Analytical Cytology\| PubMed ID: 24903900	2014
Non-invasive delivery of stealth, brain-penetrating nanoparticles across the blood-brain barrier using MRI-guided focused ultrasound. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 24979210	2014
Localized in vivo model drug delivery with intravascular ultrasound and microbubbles. Ultrasound in medicine & biology\| PubMed ID: 25130449	2014
Ultrasound-based measurement of molecular marker concentration in large blood vessels: a feasibility study. Ultrasound in medicine & biology\| PubMed ID: 25308943	2015
The local effects of ovarian diathermy in an ovine model of polycystic ovary syndrome. PloS one\| PubMed ID: 25343339	2014
In vivo imaging of microfluidic-produced microbubbles. Biomedical microdevices\| PubMed ID: 25663444	2015
Oscillatory Dynamics and In Vivo Photoacoustic Imaging Performance of Plasmonic Nanoparticle-Coated Microbubbles. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 25703465	2015
Reducing Neointima Formation in a Swine Model with IVUS and Sirolimus Microbubbles. Annals of biomedical engineering\| PubMed ID: 25893508	2015
Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli. Immunity\| PubMed ID: 25902482	2015
Therapy of prostate cancer using a novel cancer terminator virus and a small molecule BH-3 mimetic. Oncotarget\| PubMed ID: 25926554	2015
Development of target-specific liposomes for delivering small molecule drugs after reperfused myocardial infarction. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 26122651	2015
Optical Verification of Microbubble Response to Acoustic Radiation Force in Large Vessels With In Vivo Results. Investigative radiology\| PubMed ID: 26135018	2015
Ultrasound in Radiology: From Anatomic, Functional, Molecular Imaging to Drug Delivery and Image-Guided Therapy. Investigative radiology\| PubMed ID: 26200224	2015
Co-administration of Microbubbles and Drugs in Ultrasound-Assisted Drug Delivery: Comparison with Drug-Carrying Particles. Advances in experimental medicine and biology\| PubMed ID: 26486340	2016
Regulation of L-selectin-dependent hydrodynamic shear thresholding by leukocyte deformability and shear dependent bond number. Biorheology\| PubMed ID: 26600268	2015
Synthesis and Testing of Modular Dual-Modality Nanoparticles for Magnetic Resonance and Multispectral Photoacoustic Imaging. Bioconjugate chemistry\| PubMed ID: 26603129	2016
Targeted gene transfer to the brain via the delivery of brain-penetrating DNA nanoparticles with focused ultrasound. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 26732553	2016
Microglial Cells Prevent Hemorrhage in Neonatal Focal Arterial Stroke. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 26961944	2016
Histamine induces microglia activation and dopaminergic neuronal toxicity via H1 receptor activation. Journal of neuroinflammation\| PubMed ID: 27260166	2016
Non-Invasive, Focal Disconnection of Brain Circuitry Using Magnetic Resonance-Guided Low-Intensity Focused Ultrasound to Deliver a Neurotoxin. Ultrasound in medicine & biology\| PubMed ID: 27260243	2016
The Use of Acoustic Radiation Force Decorrelation-Weighted Pulse Inversion for Enhanced Ultrasound Contrast Imaging. Investigative radiology\| PubMed ID: 27495188	2017
Ultra-Low-Dose Ultrasound Molecular Imaging for the Detection of Angiogenesis in a Mouse Murine Tumor Model: How Little Can We See? Investigative radiology\| PubMed ID: 27654582	2016
Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation. Nature\| PubMed ID: 27820945	2016
Renal Collectrin Protects against Salt-Sensitive Hypertension and Is Downregulated by Angiotensin II. Journal of the American Society of Nephrology : JASN\| PubMed ID: 28062568	2017
Ultrasound Molecular Imaging of Inflammation in Mouse Abdominal Aorta. Investigative radiology\| PubMed ID: 28430714	2017
Novel Focused Ultrasound Gene Therapy Approach Noninvasively Restores Dopaminergic Neuron Function in a Rat Parkinson's Disease Model. Nano letters\| PubMed ID: 28511006	2017
Focal areas of increased lipid concentration on the coating of microbubbles during short tone-burst ultrasound insonification. PloS one\| PubMed ID: 28686673	2017
Evaluation of pharmacokinetic and pharmacodynamic profiles of liposomes for the cell type-specific delivery of small molecule drugs. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 28754465	2017
Size Exclusion HPLC Detection of Small-Size Impurities as a Complementary Means for Quality Analysis of Extracellular Vesicles. Journal of circulating biomarkers\| PubMed ID: 28936242	2015
Muscle-derived extracellular superoxide dismutase inhibits endothelial activation and protects against multiple organ dysfunction syndrome in mice. Free radical biology & medicine\| PubMed ID: 28982599	2017
In Vitro Sonothrombolysis Enhancement by Transiently Stable Microbubbles Produced by a Flow-Focusing Microfluidic Device. Annals of biomedical engineering\| PubMed ID: 29192346	2018
Targeting of microbubbles: contrast agents for ultrasound molecular imaging. Journal of drug targeting\| PubMed ID: 29258335	2018
Klf4 has an unexpected protective role in perivascular cells within the microvasculature. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 29631369	2018
Plectin-targeted liposomes enhance the therapeutic efficacy of a PARP inhibitor in the treatment of ovarian cancer. Theranostics\| PubMed ID: 29774075	2018
A flow focusing microfluidic device with an integrated Coulter particle counter for production, counting and size characterization of monodisperse microbubbles. Lab on a chip\| PubMed ID: 30070301	2018
Changes in cell fate determine the regenerative and functional capacity of the developing kidney before and after release of obstruction. Clinical science (London, England : 1979)\| PubMed ID: 30442812	2018
Formation of Microbubbles for Targeted Ultrasound Contrast Imaging: Practical Translation Considerations. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 30509068	2019
Efficacy of Sonothrombolysis Using Microbubbles Produced by a Catheter-Based Microfluidic Device in a Rat Model of Ischemic Stroke. Annals of biomedical engineering\| PubMed ID: 30689066	2019
Ultrasound molecular imaging for differentiation of benign and malignant tumors in patients. Quantitative imaging in medicine and surgery\| PubMed ID: 30701161	2018
Moving toward Noninvasive, Focused Ultrasound Therapeutic Delivery of Drugs in the Brain: Prolonged Opening of Blood-Brain Barrier May Not Be Needed. Radiology\| PubMed ID: 30917292	2019
Correction: A flow focusing microfluidic device with an integrated Coulter particle counter for production, counting and size characterization of monodisperse microbubbles. Lab on a chip\| PubMed ID: 31026008	2019
Validation of Normalized Singular Spectrum Area as a Classifier for Molecularly Targeted Microbubble Adherence. Ultrasound in medicine & biology\| PubMed ID: 31227262	2019
Monitoring Oxygenation Levels Deep in the Tumor Core: Noninvasive Imaging of Hypoxia, Now in Real-Time 3D. Cancer research\| PubMed ID: 31519775	2019
Importance of thorough tissue and cellular level characterization of targeted drugs in the evaluation of pharmacodynamic effects. PloS one\| PubMed ID: 31725756	2019
Pulsed ultrasound attenuates the hyperglycemic exacerbation of myocardial ischemia-reperfusion injury. The Journal of thoracic and cardiovascular surgery\| PubMed ID: 31839230	2019
liposomal delivery of PPARα/γ dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug effects. Theranostics\| PubMed ID: 31903139	2020
Sonoselective transfection of cerebral vasculature without blood-brain barrier disruption. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32123081	2020
Closed-loop feedback control of microbubble diameter from a flow-focusing microfluidic device. Biomicrofluidics\| PubMed ID: 32454925	2020
Augmentation of brain tumor interstitial flow via focused ultrasound promotes brain-penetrating nanoparticle dispersion and transfection. Science advances\| PubMed ID: 32494662	2020
Targeted Ultrasound Contrast Imaging of Tumor Vasculature With Positively Charged Microbubbles. Investigative radiology\| PubMed ID: 32569011	2020
Ultrasound Molecular Imaging of Cancer: Design and Formulation Strategies of Targeted Contrast Agents. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer\| PubMed ID: 32594391	2020
From Anatomy to Functional and Molecular Biomarker Imaging and Therapy: Ultrasound Is Safe, Ultrafast, Portable, and Inexpensive. Investigative radiology\| PubMed ID: 32776766	2020